公开(公告)号：US20090148396A1

公开(公告)日：2009-06-11

申请号：US12276856

申请日：2008-11-24

申请人： Laura C. AKULLIAN ,  Russell C. PETTER ,  John J. KANE ,  Charles E. HAMMOND ,  Mao YIN ,  Aleksandr YURKOVETSKIY ,  Cheri A. STEVENSON

发明人： Laura C. AKULLIAN ,  Russell C. PETTER ,  John J. KANE ,  Charles E. HAMMOND ,  Mao YIN ,  Aleksandr YURKOVETSKIY ,  Cheri A. STEVENSON

IPC分类号： A61K31/77 ,  C08F24/00 ,  C08F26/06 ,  A61P35/00 ,  A61K31/787

CPC分类号： C07D303/40 ,  A61K47/59 ,  C07D303/18 ,  C07D303/22 ,  C07D303/36 ,  C07D405/14 ,  C07D487/08

摘要： Fumagillin analog polymer conjugates, methods of making fumagillin analog polymer conjugates, compositions comprising a polymer conjugate of a fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a polymer conjugate of a fumagillin analog, are described. Also described are novel fumagillin analogs, methods of making fumagillin analogs, compositions comprising at least one fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a fumagillin analog.

摘要翻译： 烟曲霉素类似物聚合物缀合物，制备烟曲霉素类似物聚合物共轭物的方法，包含烟曲霉素类似物的聚合物缀合物的组合物，以及用于治疗癌症的方法或治疗血管发生疾病的方法，包括向有需要的受试者施用有效量的 烟曲霉素类似物。 还描述了新的烟曲霉素类似物，制备烟曲霉素类似物的方法，包含至少一种烟曲霉素类似物的组合物，以及用于治疗癌症的方法或治疗血管发生疾病，包括向有需要的受试者施用有效量的烟曲霉素类似物。

公开(公告)号：US20100305149A1

公开(公告)日：2010-12-02

申请号：US12789047

申请日：2010-05-27

申请人： Aleksandr Yurkovetskiy ,  Mao Yin ,  Gui Liu ,  Laura C. Akullian ,  John J. Kane ,  Cheri A. Stevenson ,  Charles E. Hammond ,  Russell C. Petter ,  John H. Van Duzer ,  Timothy B. Lowinger

发明人： Aleksandr Yurkovetskiy ,  Mao Yin ,  Gui Liu ,  Laura C. Akullian ,  John J. Kane ,  Cheri A. Stevenson ,  Charles E. Hammond ,  Russell C. Petter ,  John H. Van Duzer ,  Timothy B. Lowinger

IPC分类号： A61K31/439 ,  A61P35/00 ,  A61P35/04 ,  C07D487/18 ,  C07D491/22 ,  G01N33/50

CPC分类号： C07D519/04 ,  A61K47/59 ,  C07D491/22 ,  G01N2500/00 ,  Y10T436/145555

摘要： Polyal-Drug conjugates comprising a variable rate-releasing linker are described along with methods of making such conjugates. Uses for such Polyal-Drug conjugates is also described.

摘要翻译： 描述包含可变速率释放连接体的多价 - 药物共轭物以及制备这种缀合物的方法。 也描述了这种多种药物共轭物的用途。

公开(公告)号：US08524214B2

公开(公告)日：2013-09-03

申请号：US12789047

申请日：2010-05-27

申请人： Aleksandr Yurkovetskiy ,  Mao Yin ,  Gui Liu ,  Laura C. Akullian ,  John J. Kane ,  Cheri A. Stevenson ,  Charles E. Hammond ,  Russell C. Petter ,  John H. Van Duzer ,  Timothy B. Lowinger

发明人： Aleksandr Yurkovetskiy ,  Mao Yin ,  Gui Liu ,  Laura C. Akullian ,  John J. Kane ,  Cheri A. Stevenson ,  Charles E. Hammond ,  Russell C. Petter ,  John H. Van Duzer ,  Timothy B. Lowinger

IPC分类号： A61K31/045 ,  A61K31/04 ,  A61K31/13 ,  A61K31/21 ,  A61K31/33 ,  A61K31/695 ,  A61K31/765

CPC分类号： C07D519/04 ,  A61K47/59 ,  C07D491/22 ,  G01N2500/00 ,  Y10T436/145555

摘要： Polyal-Drug conjugates comprising a variable rate-releasing linker are described along with methods of making such conjugates. Uses for such Polyal-Drug conjugates is also described.

摘要翻译： 描述包含可变速率释放连接体的多价 - 药物共轭物以及制备这种缀合物的方法。 也描述了这种多种药物共轭物的用途。

公开(公告)号：US20130158046A1

公开(公告)日：2013-06-20

申请号：US13769024

申请日：2013-02-15

申请人： Laura C. Akullian ,  Russell C. Petter ,  John J. Kane ,  Charles E. Hammond ,  Mao Yin ,  Aleksandr Yurkovetskiy ,  Cheri A. Stevenson

发明人： Laura C. Akullian ,  Russell C. Petter ,  John J. Kane ,  Charles E. Hammond ,  Mao Yin ,  Aleksandr Yurkovetskiy ,  Cheri A. Stevenson

IPC分类号： C07D303/40 ,  C07D303/18

CPC分类号： C07D303/40 ,  A61K47/59 ,  C07D303/18 ,  C07D303/22 ,  C07D303/36 ,  C07D405/14 ,  C07D487/08

摘要： Fumagillin analog polymer conjugates, methods of making fumagillin analog polymer conjugates, compositions comprising a polymer conjugate of a fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a polymer conjugate of a fumagillin analog, are described. Also described are novel fumagillin analogs, methods of making fumagillin analogs, compositions comprising at least one fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a fumagillin analog.

公开(公告)号：US08399512B2

公开(公告)日：2013-03-19

申请号：US12276856

申请日：2008-11-24

申请人： Laura C. Akullian ,  Russell C. Petter ,  John J. Kane ,  Charles E. Hammond ,  Mao Yin ,  Aleksandr Yurkovetskiy ,  Cheri A. Stevenson

发明人： Laura C. Akullian ,  Russell C. Petter ,  John J. Kane ,  Charles E. Hammond ,  Mao Yin ,  Aleksandr Yurkovetskiy ,  Cheri A. Stevenson

IPC分类号： A61K31/335 ,  C07D303/00

CPC分类号： C07D303/40 ,  A61K47/59 ,  C07D303/18 ,  C07D303/22 ,  C07D303/36 ,  C07D405/14 ,  C07D487/08

摘要： Fumagillin analog polymer conjugates, methods of making fumagillin analog polymer conjugates, compositions comprising a polymer conjugate of a fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a polymer conjugate of a fumagillin analog, are described. Also described are novel fumagillin analogs, methods of making fumagillin analogs, compositions comprising at least one fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a fumagillin analog.

摘要翻译： 烟曲霉素类似物聚合物缀合物，制备烟曲霉素类似物聚合物共轭物的方法，包含烟曲霉素类似物的聚合物缀合物的组合物，以及用于治疗癌症的方法或治疗血管发生疾病的方法，包括向有需要的受试者施用有效量的 烟曲霉素类似物。 还描述了新的烟曲霉素类似物，制备烟曲霉素类似物的方法，包含至少一种烟曲霉素类似物的组合物，以及用于治疗癌症的方法或治疗血管发生疾病，包括向有需要的受试者施用有效量的烟曲霉素类似物。