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1.发明授权HIgR and related domain which binds glycoprotein D of herpes simplex virus 失效HIgR和与单纯疱疹病毒糖蛋白D结合的相关结构域公开(公告)号：US06469155B1
公开(公告)日：2002-10-22
申请号：US09435956
申请日：1999-11-09
IPC分类号： C07H2104
CPC分类号： C12N15/87 , A61K38/00 , A61K2039/505 , C07K14/705 , C07K16/2803
摘要： The present invention relates to an immunoglobulin-like protein useful in preventing or treating pathologies concerned with herpes simplex virus 1, herpes simplex virus 2 infections in humans.
摘要翻译： 本发明涉及可用于预防或治疗与单纯疱疹病毒1，单纯疱疹病毒2感染有关的病态的免疫球蛋白样蛋白。
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2.发明授权Herpes simplex virus (HSV) with modified tropism, uses and process of preparation thereof 有权具有改良趋向性的单纯疱疹病毒（HSV），其制备及其制备方法公开(公告)号：US09157071B2
公开(公告)日：2015-10-13
申请号：US12953528
申请日：2010-11-24
IPC分类号： A61K35/76 , C12N15/79 , A61K35/00 , C12N7/01 , A61K49/00 , C12N7/00 , C07K14/005 , A61K35/763
CPC分类号： A61K35/763 , A61K49/04 , C07K14/005 , C07K2317/622 , C07K2319/33 , C07K2319/61 , C07K2319/74 , C12N7/00 , C12N2710/16621 , C12N2710/16622 , C12N2710/16632 , C12N2710/16633 , C12N2710/16651 , C12N2710/16722 , C12N2810/85 , Y02A50/407
摘要： A modified Herpes Simplex Virus (HSV), which has a portion of gD (glycoprotein D) of the glycoproteic envelope deleted and a heterologous single chain antibody inserted in place of such deleted portion; the modified HSV is capable of infecting cells through receptor HER2/ErbB2 but not through receptors HVEM/HveA and nectin1/HveC; uses of the modified HSV and a process of the preparation thereof are also disclosed.
摘要翻译： 修饰的单纯疱疹病毒（HSV），其具有缺失的糖蛋白包膜的一部分gD（糖蛋白D）和插入该缺失部分的异源单链抗体; 修饰的HSV能够通过受体HER2 / ErbB2感染细胞，但不能通过受体HVEM / HveA和nectin1 / HveC感受细胞; 还公开了改性HSV的用途及其制备方法。
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3.发明申请HERPES SIMPLEX VIRUS (HSV) WITH MODIFIED TROPISM, USES AND PROCESS OF PREPARATION THEREOF 有权HERPES SIMPLEX病毒（HSV）与其修饰的TROPISM，其使用及其制备方法公开(公告)号：US20110318268A1
公开(公告)日：2011-12-29
申请号：US12953528
申请日：2010-11-24
CPC分类号： A61K35/763 , A61K49/04 , C07K14/005 , C07K2317/622 , C07K2319/33 , C07K2319/61 , C07K2319/74 , C12N7/00 , C12N2710/16621 , C12N2710/16622 , C12N2710/16632 , C12N2710/16633 , C12N2710/16651 , C12N2710/16722 , C12N2810/85 , Y02A50/407
摘要： A modified Herpes Simplex Virus (HSV), which has a portion of gD (glycoprotein D) of the glycoproteic envelope deleted and a heterologous single chain antibody inserted in place of such deleted portion; the modified HSV is capable of infecting cells through receptor HER2/ErbB2 but not through receptors HVEM/HveA and nectin1/HveC; uses of the modified HSV and a process of the preparation thereof are also disclosed.
摘要翻译： 修饰的单纯疱疹病毒（HSV），其具有缺失的糖蛋白包膜的一部分gD（糖蛋白D）和插入该缺失部分的异源单链抗体; 修饰的HSV能够通过受体HER2 / ErbB2感染细胞，但不能通过受体HVEM / HveA和nectin1 / HveC感受细胞; 还公开了改性HSV的用途及其制备方法。
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