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    Mass flowmeter
    1.
    发明授权
    Mass flowmeter 有权
    质量流量计

    公开(公告)号：US06948379B2

    公开(公告)日：2005-09-27

    申请号：US10379782

    申请日：2003-03-05

    申请人： Yousif A. Hussain ,  Chris N. Rolph ,  Neil Harrison ,  Vincent Cook ,  Lawrence Davies

    发明人： Yousif A. Hussain ,  Chris N. Rolph ,  Neil Harrison ,  Vincent Cook ,  Lawrence Davies

    IPC分类号： G01F1/84

    CPC分类号： G01F1/8418 ,  G01F1/849

    摘要： A Coriolis mass flowmeter that incorporates a straight Coriolis measuring tube, two straight connecting pipes, at least one oscillator stimulating the tube, a measuring sensor associated with the tube and a compensating cylinder, where the tube is positioned within the cylinder, the two end sections of the cylinder are solidly connected to the respective end sections of the tube, the tube transitions with either end section into a connecting pipe, the connecting pipes extending outside the compensating cylinder, and by means of mounting flanges provided on the external ends of the connecting pipes, the mass flowmeter can be installed in a pipeline system. Each connecting pipe meets the requirements of the formula M ⁢   ⁢ f 2 e ⁢   ⁢ i / l 3 > 5.5 where M is the mass of the cylinder, f is the natural frequency of the water-filled tube, e is the modulus of elasticity of the connecting pipes, i is the geometric moment of inertia of the connecting pipes and l is the length of the connecting pipes.

    摘要翻译： 科里奥利质量流量计，其包括直的科里奥利测量管，两个直的连接管，至少一个振荡管的振荡器，与管相关联的测量传感器和补偿缸，其中管定位在气缸内，两个端部 的柱体与管的相应的端部牢固地连接，管子随着任一端部转变成连接管，连接管延伸到补偿缸外部，并且通过设置在连接件的外端上的安装凸缘 管道，质量流量计可以安装在管道系统中。 每个连接管满足公式的要求： M > 5.5 其中M是气缸的质量，f是充水的固有频率 管，e是连接管的弹性模量，i是连接管的几何惯性矩，l是连接管的长度。

      Mass flowmeter
      2.
      发明授权
      Mass flowmeter 失效
      质量流量计

      公开(公告)号：US06397685B1

      公开(公告)日：2002-06-04

      申请号：US09499182

      申请日：2000-02-07

      申请人： Vincent Cook ,  Lawrence Davies ,  Neil Harrison ,  Yousif Hussain ,  Chris N. Rolph

      发明人： Vincent Cook ,  Lawrence Davies ,  Neil Harrison ,  Yousif Hussain ,  Chris N. Rolph

      IPC分类号： G01F184

      CPC分类号： G01F1/8409 ,  G01F1/8413 ,  G01F1/8418 ,  G01F1/849

      摘要： A mass flowmeter operating by the Coriolis principle and incorporating an essentially straight, moving-fluid-conducting Coriolis measuring tube, at least one oscillator associated with and exciting the Coriolis measuring tube, at least one detector associated with the Coriolis measuring tube and sensing the Coriolis forces and/or the Coriolis oscillations generated by Coriolis forces, and a compensating cylinder in which the Coriolis measuring tube is positioned, the Coriolis measuring tube and the compensating cylinder being connected to each other in which the oscillation-capable system composed of the Coriolis measuring tube and the compensating cylinder is at least to a large extent mass-equalized both for the excitation oscillation of the Coriolis measuring tube and for the Coriolis oscillation of the Coriolis measuring tube.

      摘要翻译： 通过科里奥利原理运行的质量流量计，并结合基本上直的，运动流体导电的科里奥利测量管，至少一个与科里奥利测量管相关联的振荡器和至少一个与科里奥利测量管相关的探测器，并感测科里奥利 科里奥利力产生的力和/或科里奥利振荡，以及科里奥利测量管所在的补偿气缸，科里奥利测量管和补偿气缸彼此连接，其中由科里奥利测量组成的振荡系统 管和补偿缸至少对科里奥利测量管的激发振荡和科里奥利测量管的科里奥利振荡都进行了大量的质量均衡。

      Device for measuring the mass rate of flow having a bobbin for a magnetic coil made from a material having a specific thermal conductivity
      3.
      发明授权
      Device for measuring the mass rate of flow having a bobbin for a magnetic coil made from a material having a specific thermal conductivity 有权
      用于测量具有由具有特定热导率的材料制成的用于电磁线圈的线轴的流量的装置

      公开(公告)号：US07543509B2

      公开(公告)日：2009-06-09

      申请号：US11463750

      申请日：2006-08-10

      申请人： Lawrence Davies

      发明人： Lawrence Davies

      IPC分类号： G01F1/84

      CPC分类号： G01F1/8422 ,  G01F1/849 ,  H01F7/20 ,  H01F27/22

      摘要： A device for measuring the mass rate of flow which operates according to the Coriolis principle, with a measurement tube (1) and a magnet coil (7) of a bobbin (9) and a winding (10) attached to it for exciting and/or detecting vibrations of the measurement tube (1). The bobbin (9) of the magnet coil (7) has a specific thermal conductivity of at least 1 W/(K m). This enables the heat which forms in the magnet coil (7) to be efficiently dissipated to the surrounding vicinity without cooling elements, such as cooling fins, being necessary. In this way, the efficiency of the device for measuring the mass rate of flow using the Coriolis principle is altogether improved.

      摘要翻译： 一种用于测量根据科里奥利原理工作的质量流量的装置，其具有附接到其上的测量管（1）和线圈架（9）的磁体线圈（7）和用于激励和/ 或检测测量管（1）的振动。 磁体线圈（7）的线轴（9）具有至少1W /（K m）的比热导率。 这使得能够有效地将磁体线圈（7）中形成的热量散发到周围的周围，而不需要诸如冷却片的冷却元件。 以这种方式，使用科里奥利原理测量质量流量的装置的效率完全改善。

      Active-constraint robots
      6.
      发明授权
      Active-constraint robots 有权
      主动约束机器人

      公开(公告)号：US07035716B2

      公开(公告)日：2006-04-25

      申请号：US10470314

      申请日：2002-01-29

      申请人： Simon James Harris ,  Brian Lawrence Davies ,  Matjaz Jakopec

      发明人： Simon James Harris ,  Brian Lawrence Davies ,  Matjaz Jakopec

      IPC分类号： G06F19/00

      CPC分类号： B25J9/1689 ,  A61B34/10 ,  A61B34/30 ,  A61B34/70 ,  A61B34/76 ,  A61B2034/107 ,  A61B2090/08021 ,  A61B2090/365 ,  G05B2219/34141 ,  G05B2219/40146 ,  G05B2219/45117 ,  G06F19/00

      摘要： An active-constraint robot (4), particularly for surgical use, is controlled by means of a series of motorized joints to provide a surgeon with real-time tactile feedback of an operation in progress. The robot system holds, in memory, a series of constraint surfaces beyond which it would be dangerous for the surgeon to go, and a resistive force is applied to the cutting tool (14) as the surgeon approaches any such surface. To improve the overall quality of feedback experienced by the surgeon, the resistive force applied to the cutting tool (14) depends upon the point of intersection (I) between the force factor applied by the surgeon and the surface. Further improvements are achieved by adjusting the tangential resistive force, when the tool is adjacent to the surface, in dependence upon the surrounding shape of the surface.

      摘要翻译： 特别是外科用途的主动约束机器人（4）通过一系列电动关节来控制，以向外科医生提供正在进行的手术的实时触觉反馈。 机器人系统在存储器中保持一系列约束表面，超过该限制表面对于外科医生来说将是危险的，当外科医生接近任何这样的表面时，阻力被施加到切割工具（14）。 为了提高外科医生所经历的反馈的总体质量，施加到切割工具（14）的阻力取决于由外科医生施加的力因子与表面之间的交叉点（I）。 根据表面的周围形状，通过调整刀具相邻于表面的切向阻力来实现进一步的改进。

      IMIDAZO[4, 5-B]PYRIDIN-2-ONE AND OXAZOLO[4, 5-B]PYRIDIN-2-ONE COMPOUNDS AND ANALOGS THEREOF AS CANCER THERAPEUTIC COMPOUNDS
      7.
      发明申请
      IMIDAZO[4, 5-B]PYRIDIN-2-ONE AND OXAZOLO[4, 5-B]PYRIDIN-2-ONE COMPOUNDS AND ANALOGS THEREOF AS CANCER THERAPEUTIC COMPOUNDS 失效

      公开(公告)号：US20090325945A1

      公开(公告)日：2009-12-31

      申请号：US12298325

      申请日：2007-04-26

      申请人： Dan Niculescu-Duvaz ,  Caroline Joy Springer ,  Richard Malcolm Marais ,  Harmen Dijkstra ,  Delphine Menard ,  Ion Niculescu-Duvaz ,  Lawrence Davies ,  Arnaud Nourry

      发明人： Dan Niculescu-Duvaz ,  Caroline Joy Springer ,  Richard Malcolm Marais ,  Harmen Dijkstra ,  Delphine Menard ,  Ion Niculescu-Duvaz ,  Lawrence Davies ,  Arnaud Nourry

      IPC分类号： A61K31/541 ,  C07D471/02 ,  A61K31/437

      CPC分类号： C07D471/04

      摘要： The present invention pertains to certain imidazo[4,5-b]pyridin-2-one and oxazolo[4,5 b]pyridin-2-one compounds and analogs thereof, which, inter alia, inhibit RAF (e.g., B RAF) activity, inhibit cell proliferation, treat cancer, etc., and more particularly to compounds of the formulae: wherein: J is independently —O— or —NRN1−; RN1, if present, is independently —H or a substituent; RN2 is independently —H or a substituent; Y is independently —CH═ or —N═; Q is independently —(CH2)j-M-(CH2)k— wherein: j is independently 0, 1 or 2; k is independently 0, 1, or 2; j+k is 0, 1, or 2; M is independently O—, —S—, —NH—, —NMe-, or —CH2—; each of RP1, RP2, RP5, and RP4 is independently —H or a substituent; and additionally RP1 and RP2 taken together may be CH═CH—CH═CH—; and additionally RP1 and RP5 taken together may be CH═CH—CH═CH—; L is independently: a linker group formed by a chain of 2, 3, or 4 linker moieties; each linker moiety is independently CH2—, —NRN—, —C(═X)—, or —S(═O)2—; either: exactly one linker moiety is —NRN—, or: exactly two linker moieties are —NRN—; either: exactly one linker moiety is —C(═X)—, and no linker moiety is —S(═O)2—, or: exactly one linker moiety is —S(═O)2—, and no linker moiety is —C(═X)—; no two adjacent linker moieties are —NRN—; X is independently ═O or ═S; each RN is independently —H or a substituent; A is independently: C6-14carboaryl, C5-14heteroaryl, C3-12carbocyclic, C3-12heterocyclic; and is independently unsubstituted or substituted; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, N-oxides, chemically protected forms, and prodrugs thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit RAF (e.g., B-RAF) activity, to inhibit receptor tyrosine kinase (RTK) activity, to inhibit cell proliferation, and in the treatment of diseases and conditions that are ameliorated by the inhibition of RAF, RTK, etc., proliferative conditions such as cancer (e.g., colorectal cancer, melanoma), etc.

      DEVICE FOR MEASURING THE MASS RATE OF FLOW
      8.
      发明申请
      DEVICE FOR MEASURING THE MASS RATE OF FLOW 有权
      用于测量流量的大小的装置

      公开(公告)号：US20070062309A1

      公开(公告)日：2007-03-22

      申请号：US11463750

      申请日：2006-08-10

      申请人： Lawrence DAVIES

      发明人： Lawrence DAVIES

      IPC分类号： G01F1/84

      CPC分类号： G01F1/8422 ,  G01F1/849 ,  H01F7/20 ,  H01F27/22

      摘要： A device for measuring the mass rate of flow which operates according to the Coriolis principle, with a measurement tube (1) and a magnet coil (7) of a bobbin (9) and a winding (10) attached to it for exciting and/or detecting vibrations of the measurement tube (1). The bobbin (9) of the magnet coil (7) has a specific thermal conductivity of at least 1 W/(K m). This enables the heat which forms in the magnet coil (7) to be efficiently dissipated to the surrounding vicinity without cooling elements, such as cooling fins, being necessary. In this way, the efficiency of the device for measuring the mass rate of flow using the Coriolis principle is altogether improved.

      摘要翻译： 一种用于测量根据科里奥利原理工作的质量流量的装置，其具有附接到其上的测量管（1）和线圈架（9）的磁体线圈（7）和用于激励和/ 或检测测量管（1）的振动。 磁体线圈（7）的线轴（9）具有至少1W /（K m）的比热导率。 这使得能够有效地将磁体线圈（7）中形成的热量散发到周围的周围，而不需要诸如冷却片的冷却元件。 以这种方式，使用科里奥利原理测量质量流量的装置的效率完全改善。

      Coriolis mass flowmeter with a ceramic measuring tube
      10.
      发明授权
      Coriolis mass flowmeter with a ceramic measuring tube 失效
      科里奥利质量流量计，带陶瓷测量管

      公开(公告)号：US06474175B2

      公开(公告)日：2002-11-05

      申请号：US09748591

      申请日：2000-12-22

      申请人： Lawrence Davies ,  Yousif Hussain ,  Chris N. Rolph

      发明人： Lawrence Davies ,  Yousif Hussain ,  Chris N. Rolph

      IPC分类号： G01F184

      CPC分类号： G01F15/185 ,  G01F1/8409 ,  G01F1/8413 ,  G01F1/849 ,  G01F15/006

      摘要： A mass flowmeter operating by the Coriolis principle incorporates a straight Coriolis measuring tube through which flows a fluid or medium, at least one oscillator associated with and exciting the Coriolis measuring tube, and at least one detector associated with the Coriolis measuring tube for capturing the Coriolis forces and/or the Coriolis-force-induced oscillations. To provide a Coriolis flowmeter incorporating a Coriolis measuring tube which is subject to only minimal thermal expansion and, accordingly, to only minimal thermal stress, and which is resistant to chemicals, the Coriolis measuring tube is made of a ceramic material.

      摘要翻译： 由科里奥利原理操作的质量流量计包含一个直的科里奥利测量管，通过该测量管流动流体或介质，与科里奥利测量管相关联的至少一个振荡器，以及与用于捕获科里奥利的科里奥利测量管相关联的至少一个检测器 力和/或科里奥利力引起的振荡。 为了提供科里奥利流量计，该流量计包含科里奥利测量管，该测量管仅承受最小的热膨胀，因此只有最小的热应力，并且耐化学物质，科里奥利测量管由陶瓷材料制成。