公开(公告)号：US20100174202A1

公开(公告)日：2010-07-08

申请号：US12350412

申请日：2009-01-08

申请人： Lawrence T. Hersh ,  Sai Kolluri ,  Bruce A. Friedman ,  Richard Medero

发明人： Lawrence T. Hersh ,  Sai Kolluri ,  Bruce A. Friedman ,  Richard Medero

IPC分类号： A61B5/0225

CPC分类号： A61B5/0225 ,  A61B5/02225 ,  A61B5/0402 ,  A61B5/1455

摘要： A blood pressure measurement system that utilizes a non-invasive blood pressure (NIBP) monitor having a blood pressure cuff and pressure transducer. The measurement system provides a plurality of separate processing techniques that each receive a plurality of oscillometric waveform sample values generated using the pressure transducer. Each of the processing techniques separately generates a set of envelope points based upon the oscillometric data values. The sets of envelope points are appropriately scaled such that the sets of scaled envelope points are combined with each other to create a set of combined, scaled envelope points. Various different methods can be used to scale the sets of envelope points prior to the combination of the scaled envelope points. Based upon the combination of scaled envelope points, the blood pressure is calculated and displayed by the NIBP monitor.

摘要翻译： 一种血压测量系统，其利用具有血压袖带和压力换能器的非侵入性血压（NIBP）监测器。 测量系统提供多个单独的处理技术，每个处理技术接收使用压力传感器产生的多个示波波形采样值。 每个处理技术基于示波器数据值分别产生一组包络点。 适当地缩放包络点集合，使得缩放包络点的集合彼此组合以创建一组组合的，缩放的包络点。 可以使用各种不同的方法在缩放的包络点的组合之前缩放包络点集合。 根据缩放的包络点的组合，由NIBP监视器计算和显示血压。

公开(公告)号：US06648828B2

公开(公告)日：2003-11-18

申请号：US09683916

申请日：2002-03-01

申请人： Bruce A. Friedman ,  Richard Medero ,  Lawrence T. Hersh ,  Sai Kolluri

发明人： Bruce A. Friedman ,  Richard Medero ,  Lawrence T. Hersh ,  Sai Kolluri

IPC分类号： A61B502

CPC分类号： A61B5/0285 ,  A61B5/021 ,  A61B5/02125 ,  A61B5/0295

摘要： Blood pressure is measured using the pulse transit time required for the blood volume pulse to propagate between two locations in an animal. Impedance plethysmography is employed to detect when the blood volume pulse occurs at one location. The plethysmograph may detect thoracic impedance to determine when the aortic heart valve opens or it may detect impedance at one location on a limb of the animal. Occurrence of the blood volume pulse at another location can be determined by impedance plethysmography or another technique, such as pulse oximetry. The calculation of cardiac stroke volume can be employed to compensate the derivation of the blood pressure for effects due to blood vessel compliance. A nonblood pressure monitor may periodically provide a reference blood pressure measurement that is used calibrate derivation of the blood pressure based on the pulse transit time.

摘要翻译： 使用血液体积脉冲在动物的两个位置之间传播所需的脉搏传播时间来测量血压。 采用阻抗体积描记法检测血液体积脉搏何时出现在一个位置。 体积描记器可以检测胸部阻抗以确定主动脉瓣心脏瓣膜何时打开，或者可以在动物肢体的一个位置处检测阻抗。 可以通过阻抗体积描记法或其他技术（例如脉搏血氧测定法）来确定另一位置处的血容量脉冲的发生。 心脏搏动量的计算可用于补偿由于血管依从性引起的血压的推导。 非血压监视器可以周期性地提供参考血压测量，其用于基于脉冲传播时间来校准血压的推导。

公开(公告)号：US06423010B1

公开(公告)日：2002-07-23

申请号：US09678650

申请日：2000-10-04

申请人： Bruce Friedman ,  Lawrence T. Hersh ,  Christopher J. Dedyo

发明人： Bruce Friedman ,  Lawrence T. Hersh ,  Christopher J. Dedyo

IPC分类号： A61B502

CPC分类号： A61B5/02225 ,  A61B5/021 ,  A61B5/02416 ,  A61B5/0402

摘要： The present invention relates to an improved apparatus and method for measuring blood pressure. Both include a first sensor for detecting an instantaneous pulse rate, an inflatable cuff, and a second sensor to monitoring the pressure within the cuff. The cuff sensor adapted to detect oscillometric complexes associated with a patient's pulse. Both the apparatus and the method provide for detecting arrhythmia from the patient's instantaneous pulse rate. A characteristic of the oscillometric complexes is measured, and match determination means provided for determining whether at least two adjacent oscillometric complexes are equivalent. A first set matching criteria are used under normal conditions. A second set of matching criteria are used when arrhythmia are detected. A controller is provided for controlling the pressure within the cuff. At the outset of a blood pressure measurement the cuff is inflated to a pressure greater than the patient's systolic pressure. In response to a determination that two adjacent oscillometric complexes are equivalent the control means reduces the cuff pressure by a fixed increment and the match determination means continues to determine whether adjacent complexes are equivalent. A blood pressure determination means is provided responsive to the control means and the measuring means. The blood pressure determination means compares the measured characteristic of the oscillometric complexes from various cuff pressures and determines the cuff pressure at which the measured characteristic reaches a limit. This cuff pressure corresponds to the patient's mean arterial pressure.

摘要翻译： 本发明涉及一种用于测量血压的改进的装置和方法。 两者都包括用于检测瞬时脉率的第一传感器，可充气袖带和用于监测袖带内的压力的第二传感器。 袖带传感器适于检测与患者脉搏相关联的示波复合物。 该装置和方法都提供从患者的瞬时脉搏率中检测心律失常。 测量示波复合物的特性，并且提供用于确定至少两个相邻示波复合物是否相当的匹配确定装置。 在正常条件下使用第一组匹配标准。 当检测到心律失常时，使用第二组匹配标准。 提供控制器来控制袖带内的压力。 在血压测量开始时，将袖带充气至大于患者收缩压的压力。 响应于确定两个相邻示波复合体是等效的，控制装置将袖带压力减小固定的增量，并且匹配确定装置继续确定相邻复合体是否相等。 响应于控制装置和测量装置提供血压确定装置。 血压测定装置比较来自各种袖带压力的示波复合物的测量特性，并确定测量特征达到极限的袖带压力。 该袖带压力对应于患者的平均动脉压。

公开(公告)号：US08556821B2

公开(公告)日：2013-10-15

申请号：US12034143

申请日：2008-02-20

申请人： Lawrence T. Hersh ,  Sai Kolluri ,  Robert F. Donehoo

发明人： Lawrence T. Hersh ,  Sai Kolluri ,  Robert F. Donehoo

IPC分类号： A61B5/22

CPC分类号： A61B5/0225 ,  A61B5/02225 ,  A61B5/024 ,  A61B5/7257

摘要： A system for processing oscillometric data from a plurality of pressure steps to determine the blood pressure of a patient as disclosed herein. A heart rate monitor connected to the patient acquires the patient's heart rate. A time to frequency domain converter receives oscillometric data and converts the oscillometric data into the frequency domain. A harmonic frequency calculator is connected to the heart rate monitor and derives at least the heart rate fundamental frequency. A filter connected to the time to frequency domain converter and the harmonic frequency calculator that produces a filter frequency domain oscillometric signal. A reconstruction calculator receives the filtered frequency domain oscillometric signal and reconstructs a time domain oscillometric signal. A method of computing an oscillometric envelope for use in determining the blood pressure of a patient is also disclosed herein.

摘要翻译： 一种用于从多个压力步骤处理示波数据以确定如本文所公开的患者的血压的系统。 连接到患者的心率监测器获取患者的心率。 一段时间到频域转换器接收示波数据并将示波数据转换成频域。 谐波频率计算器连接到心率监测器，并至少得出心率基频。 连接到时域转换器的滤波器和产生滤波器频域示波信号的谐波频率计算器。 重建计算器接收滤波后的频域示波信号并重构时域示波信号。 本文还公开了计算用于确定患者的血压的示波包络的方法。

公开(公告)号：US08211030B2

公开(公告)日：2012-07-03

申请号：US12412057

申请日：2009-03-26

申请人： Robert F. Donehoo ,  Lawrence T. Hersh ,  Sai Kolluri

发明人： Robert F. Donehoo ,  Lawrence T. Hersh ,  Sai Kolluri

IPC分类号： A61B5/02

CPC分类号： A61B5/022 ,  A61B5/02225 ,  A61B5/7239

摘要： A method and system for operating a non-invasive blood pressure monitor that utilizes an SpO2 plethysmograph waveform to determine the initial inflation pressure for the NIBP monitor. A pulse sensor is placed on the patient's limb distal to the blood pressure cuff and provides a pulse waveform to the NIBP monitor. The NIBP monitor calculates a second derivative of the pulse waveform, which includes a series of acceleration peaks corresponding to pulse signals within the pulse waveform. When the blood pressure cuff reaches systolic pressure, the acceleration peaks contained within the acceleration waveform are eliminated, thus providing an indication that the cuff pressure has reached systolic pressure for the patient. Use of the SPO2 plethysmograph signal to determine the initial inflation pressure reduces both the over-inflation of the blood pressure cuff and the under-inflation of the blood pressure cuff, which increases the rate at which the blood pressure measurement can be made while increasing patient comfort.

摘要翻译： 一种用于操作非侵入性血压监测器的方法和系统，其利用SpO2体积描记器波形来确定NIBP监测器的初始充气压力。 将脉搏传感器放置在远离血压袖带的患者肢体上，并向NIBP监护仪提供脉搏波形。 NIBP监视器计算脉搏波形的二阶导数，其包括与脉冲波形内的脉冲信号相对应的一系列加速度峰值。 当血压袖带达到收缩压时，加速波形中包含的加速度峰值被消除，从而提供袖带压力已达到患者收缩压的指示。 使用SPO2体积描记器信号来确定初始充气压力会降低血压袖带的过度充气和血压袖带的欠充气，从而增加患者血压测量的速度，同时增加患者 安慰。

公开(公告)号：US20120157791A1

公开(公告)日：2012-06-21

申请号：US12970103

申请日：2010-12-16

申请人： Lawrence T. Hersh

发明人： Lawrence T. Hersh

IPC分类号： A61B5/00

CPC分类号： A61B5/725 ,  A61B5/02225 ,  A61B5/024 ,  A61B5/0402

摘要： A system and method for processing a cuff pressure waveform to determine the blood pressure of a patient. A heart rate monitor acquires the patient's heart rate. Based upon the acquired heart rate, the system selects filtering parameters for processing the cuff pressure waveform received from the patient. The filtering parameters include a high pass cutoff frequency and a low pass cutoff frequency that are determined based upon the heart rate of the patient. The low pass cutoff frequency is based upon a harmonic frequency of the heart rate while the high pass cutoff frequency is based upon the fundamental frequency of the heart rate. The high pass and low pass cutoff frequencies are used to select filtering coefficients. The high pass and low pass cutoff frequencies are selected based upon the heart rate of the patient such that the filtering adapts based on the heart rate of the patient.

摘要翻译： 一种用于处理袖带压波形以确定患者的血压的系统和方法。 心率监测器获取患者的心率。 基于所获取的心率，系统选择用于处理从患者接收的袖带压波形的滤波参数。 滤波参数包括基于患者心率确定的高通截止频率和低通截止频率。 低通截止频率基于心率的谐波频率，而高通截止频率基于心率的基频。 高通和低通截止频率用于选择滤波系数。 基于患者的心率来选择高通和低通截止频率，使得滤波基于患者的心率适应。

公开(公告)号：US08064991B2

公开(公告)日：2011-11-22

申请号：US11970553

申请日：2008-01-08

申请人： Lawrence T. Hersh ,  Sai Kolluri ,  Bruce A. Friedman

发明人： Lawrence T. Hersh ,  Sai Kolluri ,  Bruce A. Friedman

IPC分类号： A61B5/0444

CPC分类号： A61B5/0444 ,  A61B5/04017 ,  A61B5/0472 ,  A61B5/04882 ,  A61B5/4362 ,  A61B5/7257 ,  G06F19/00 ,  G06K9/00536

摘要： A method of utilizing maternal-fetal monitoring system to monitor the physiological properties of both a maternal patient and a fetus. The method places a series of ECG electrodes across the maternal patient's abdomen and receives ECG input waveforms across a plurality of separate channels. The method processes the channels using an ICA algorithm to generate a series of ICA output waveforms. The ICA output waveforms are analyzed for each individual epoch to determine which of the channels include a maternal signal or a fetal signal source. Based upon the determination of which channel includes the fetal and maternal signals, further processing is carried out on the ICA output waveform on the identified channel to obtain physiological properties for the patient and the fetus. During the next epoch, the same signal processing occurs, such that the system can identify the fetal and maternal signals even as the fetal and maternal jump channels from one epoch to another.

摘要翻译： 一种利用母胎监测系统监测母亲患者和胎儿生理特性的方法。 该方法将一系列ECG电极放置在母亲患者的腹部上，并在多个单独的通道中接收ECG输入波形。 该方法使用ICA算法处理信道以产生一系列ICA输出波形。 分析每个独立时期的ICA输出波形，以确定哪些通道包括母体信号或胎儿信号源。 基于哪个信道包括胎儿和母体信号的确定，对所识别的信道上的ICA输出波形进行进一步处理，以获得患者和胎儿的生理特性。 在下一个时代，发生相同的信号处理，使得系统可以识别胎儿和母亲信号，即使胎儿和母亲的跳跃信道从一个时期到另一个时代。

公开(公告)号：US07831300B2

公开(公告)日：2010-11-09

申请号：US12034129

申请日：2008-02-20

申请人： Sai Kolluri ,  Bruce A. Friedman ,  Lawrence T. Hersh ,  Rush Winslow Hood, Jr.

发明人： Sai Kolluri ,  Bruce A. Friedman ,  Lawrence T. Hersh ,  Rush Winslow Hood, Jr.

IPC分类号： A61B5/0245

CPC分类号： A61B5/0444 ,  A61B5/4362

摘要： A method of utilizing a maternal-fetal monitoring system to monitor the physiological properties of both a maternal patient and a fetus. A series of ECG electrodes are placed across the maternal patient's abdomen and receives ECG input waveforms across sixteen separate channels. The sixteen channels of information are processed using an ICA algorithm to generate a series of ICA output waveforms and a transfer matrix. Following the current epoch, the transfer matrix is applied to the input waveforms on a continuous basis. The conditioned input waveforms are displayed immediately following the first epoch and prior to the expiration of a subsequent epoch. The transfer matrix for the second epoch is combined with the transfer matrix for the first epoch to generate an updated transfer matrix. Various filtering operations on the transfer matrix coefficients may be used to find the updated transfer matrix before the end of the current epoch.

摘要翻译： 一种利用母胎监测系统来监测母亲患者和胎儿的生理特性的方法。 一系列ECG电极放置在母亲患者的腹部，并接收跨16个独立通道的ECG输入波形。 使用ICA算法处理16个信道的信道，以生成一系列ICA输出波形和传送矩阵。 在当前时代之后，传输矩阵连续地应用于输入波形。 条件输入波形显示在第一纪元之后，并在随后的时期到期之前。 将第二纪元的传递矩阵与第一纪元的传输矩阵组合以生成更新的传送矩阵。 可以使用传递矩阵系数上的各种滤波操作来在当前时期结束之前找到更新的传输矩阵。

公开(公告)号：US20080235058A1

公开(公告)日：2008-09-25

申请号：US12133922

申请日：2008-06-05

申请人： Bruce A. Friedman ,  John W. Booth ,  Richard Medero ,  Lawrence T. Hersh ,  Sai Kolluri

发明人： Bruce A. Friedman ,  John W. Booth ,  Richard Medero ,  Lawrence T. Hersh ,  Sai Kolluri

IPC分类号： G06Q50/00

CPC分类号： A61B5/022 ,  A61B5/0205 ,  A61B5/02225 ,  A61B5/0225 ,  A61B5/024 ,  G06Q50/24

摘要： A vital sign monitoring system that can be used with multiple patients and utilizes historic patient data information for the patient to optimize the process of obtaining current vital sign measurements. Each patient is identified with a unique patient identification device that is automatically detected by the vital sign monitor. The vital sign monitor communicates with a medical records database and obtains historic patient data information and previously diagnosed characteristics for the patient identified by the patient identification device. The historic patient data information and previously diagnosed characteristics of the patient can be utilized by the vital sign monitor to set alarm limits for the vital sign measurements and automatically adjust the blood pressure estimation algorithm of the NIBP monitor.

摘要翻译： 一个生命体征监测系统，可与多个患者一起使用，并利用患者的历史患者数据信息来优化获取当前生命体征测量的过程。 每个患者都有一个唯一的患者识别装置，由生命体征监测器自动检测。 生命体征监测器与医疗记录数据库进行通信，并获得由患者识别装置识别的患者的历史患者数据信息和先前诊断的特征。 患者的历史患者数据信息和先前诊断的特征可由生命体征监测器用于设置生命体征测量的报警限值，并自动调整NIBP监测器的血压估计算法。

公开(公告)号：US07390302B2

公开(公告)日：2008-06-24

申请号：US11464918

申请日：2006-08-16

申请人： Bruce A. Friedman ,  John W. Booth ,  Lawrence T. Hersh

发明人： Bruce A. Friedman ,  John W. Booth ,  Lawrence T. Hersh

IPC分类号： A61B5/02

CPC分类号： A61B5/02255 ,  A61B5/02141 ,  A61B5/02225

摘要： A method and system for operating a non-invasive blood pressure monitor that utilizes an SpO2 plethysmograph signal to determine the initial inflation pressure for the blood pressure cuff of the NIBP monitor. A pulse sensor is placed on the patient's limb distal to the blood pressure cuff such that as the blood pressure cuff is inflated, the pulse signals from the pulse sensor will be reduced. When the blood pressure cuff reaches systolic pressure, the pulse signals from the pulse sensor will be initially attenuated and eventually eliminated, thus providing an indication that the cuff pressure has reached systolic pressure for the patient. The central processor of the NIBP monitor compares the pulse signals during cuff inflation to an average pulse signal and terminates the inflation of the blood pressure cuff upon sufficient attenuation. The use of the SpO2 plethysmograph signal to determine the initial inflation pressure reduces both the over-inflation of the blood pressure cuff and the under-inflation of the blood pressure cuff which increases the rate at which the blood pressure measurement can be made while increasing patient comfort.

摘要翻译： 一种用于操作使用SpO 2体积描记信号的无创血压监测器来确定NIBP监测器的血压袖带的初始充气压力的方法和系统。 将脉搏传感器放置在远离血压套管的患者肢体上，使得当血压袖带膨胀时，来自脉冲传感器的脉冲信号将被减小。 当血压袖带达到收缩压时，来自脉冲传感器的脉冲信号将被初始衰减并最终消除，从而提供袖带压已达到患者的收缩压的指示。 NIBP监视器的中央处理器将袖带充气期间的脉冲信号与平均脉冲信号进行比较，并在充分衰减后终止血压袖带的充气。 使用SpO 2体积描记器信号来确定初始充气压力降低了血压袖带的过度充气和血压袖带的不足充气，这增加了血液 可以在增加患者舒适度的同时进行压力测量。