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公开(公告)号：US20160002225A1
公开(公告)日：2016-01-07
申请号：US14790978
申请日：2015-07-02
申请人： Wei CHEN , Longcheng WANG , Shunqi YAN , David J. LOURY , Zhaozhong J. JIA , Leah Lynn FRYE , Jeremy Robert GREENWOOD , Mee Yoo SHELLEY , Gordana Babic ATALLAH , Riccardo ZANALETTI , Maria Pia CATALANI , Luca Francesco RAVEGLIA
发明人： Wei CHEN , Longcheng WANG , Shunqi YAN , David J. LOURY , Zhaozhong J. JIA , Leah Lynn FRYE , Jeremy Robert GREENWOOD , Mee Yoo SHELLEY , Gordana Babic ATALLAH , Riccardo ZANALETTI , Maria Pia CATALANI , Luca Francesco RAVEGLIA
IPC分类号： C07D471/04 , C07D519/00 , C07D471/06 , C07D487/04
CPC分类号： C07D471/04 , C07D471/06 , C07D487/04 , C07D519/00
摘要： Disclosed herein are compounds that inhibit Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition, reversible inhibitors of Btk are also described. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
摘要翻译： 本文公开了抑制Bruton酪氨酸激酶（Btk）的化合物。 还描述了Btk的不可逆抑制剂。 此外，还描述了Btk的可逆抑制剂。 还公开了包含化合物的药物组合物。 公开了使用Btk抑制剂的方法，单独或与其它治疗剂组合用于治疗自身免疫性疾病或病症，异种免疫疾病或病症，癌症，包括淋巴瘤和炎性疾病或病症。
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公开(公告)号：US20120283238A1
公开(公告)日：2012-11-08
申请号：US13347610
申请日：2012-01-10
申请人： Donna L. Romero , Matthew David Wessel , Shaughnessy Robinson , Jeremy Robert Greenwood , Karl Shawn Watts , Leah Lynn Frye , Geraldine C. Harriman , Alan Franklin Corin , Craig E. Masse
发明人： Donna L. Romero , Matthew David Wessel , Shaughnessy Robinson , Jeremy Robert Greenwood , Karl Shawn Watts , Leah Lynn Frye , Geraldine C. Harriman , Alan Franklin Corin , Craig E. Masse
IPC分类号： A61K31/519 , A61K31/5377 , A61P35/00 , A61P19/06 , A61P19/02 , A61P17/06 , A61P17/00 , A61P17/14 , A61P29/00 , A61P25/00 , A61P1/00 , A61P1/02 , A61P27/02 , A61P11/02 , A61P37/00 , A61P37/08 , A61P7/06 , A61P1/16 , A61P21/04 , A61P31/00 , A61P3/10 , A61P3/00 , A61P3/04 , A61P31/18 , A61P25/08 , A61P9/10 , A61P9/04 , A61P11/06 , A61P11/00 , A61P37/06 , C07D495/04
CPC分类号： A61K31/519 , A61K31/5377 , C07D495/04
摘要： The present invention provides compounds, compositions thereof, and methods of using the same.
摘要翻译： 本发明提供化合物，其组合物及其使用方法。
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3.再颁专利Phenylpyrrolidines, phenylimidazolidines,3-phenyl-1,3-oxizolidines and 3-phenyl-1,3-thiazolidines and their use in the treatment of inflammatory disease 有权苯基吡咯烷酮，苯基咪唑烷，3-苯基-1,3-恶唑烷和3-苯基-1,3-噻唑烷及其在治疗炎性疾病中的应用公开(公告)号：USRE38132E1
公开(公告)日：2003-06-03
申请号：US10167732
申请日：2002-06-12
IPC分类号： A61K314439
CPC分类号： C07D207/408 , C07D207/40 , C07D231/12 , C07D233/56 , C07D233/74 , C07D233/76 , C07D233/78 , C07D233/80 , C07D233/84 , C07D233/86 , C07D249/08 , C07D263/44 , C07D401/04 , C07D401/06 , C07D401/10 , C07D403/06 , C07D405/06 , C07D405/10 , C07D405/12 , C07D409/06 , C07F9/59 , C07F9/6506 , C07F9/65583
摘要： A method treating or preventing inflammatory and immune cell-mediated diseases by the administration of certain novel and known small molecules. Exemplary of the novel compounds are those of the following structural formulas:
摘要翻译： 通过给予某些新颖且已知的小分子来治疗或预防炎症和免疫细胞介导的疾病的方法。 新化合物的实例是下列结构式的化合物：
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4.发明授权Phenylpyrrolidines, phenylimidazolidines, 3-phenyl-1,3-oxizolidines and 3-phenyl-1,3-thiazolidines and their use in the treatment of inflammatory disease 有权苯基吡咯烷酮，苯基咪唑烷，3-苯基-1,3-恶唑烷和3-苯基-1,3-噻唑烷及其在治疗炎性疾病中的应用公开(公告)号：US06355664B1
公开(公告)日：2002-03-12
申请号：US09375010
申请日：1999-08-16
IPC分类号： A61K314439
CPC分类号： C07D207/408 , C07D207/40 , C07D231/12 , C07D233/56 , C07D233/74 , C07D233/76 , C07D233/78 , C07D233/80 , C07D233/84 , C07D233/86 , C07D249/08 , C07D263/44 , C07D401/04 , C07D401/06 , C07D401/10 , C07D403/06 , C07D405/06 , C07D405/10 , C07D405/12 , C07D409/06 , C07F9/59 , C07F9/6506 , C07F9/65583
摘要： A method treating or preventing inflammatory and immune cell-mediated diseases by the administration of certain novel and known small molecules. Exemplary of the novel compounds are those of the following structural formulas:
摘要翻译： 通过给予某些新颖且已知的小分子来治疗或预防炎症和免疫细胞介导的疾病的方法。 新化合物的实例是下列结构式的化合物：
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公开(公告)号：US08703941B2
公开(公告)日：2014-04-22
申请号：US13347610
申请日：2012-01-10
申请人： Donna L. Romero , Matthew David Wessel , Shaughnessy Robinson , Jeremy Robert Greenwood , Karl Shawn Watts , Leah Lynn Frye , Geraldine C. Harriman , Alan Franklin Corin , Craig E. Masse , Mee Shelley
发明人： Donna L. Romero , Matthew David Wessel , Shaughnessy Robinson , Jeremy Robert Greenwood , Karl Shawn Watts , Leah Lynn Frye , Geraldine C. Harriman , Alan Franklin Corin , Craig E. Masse , Mee Shelley
IPC分类号： C07D419/14
CPC分类号： A61K31/519 , A61K31/5377 , C07D495/04
摘要： The present invention provides thienopyrimidine and thienopyridine compounds, compositions thereof, and methods of using the same for the treatment of diseases mediated by IRAK enzymes. Such diseases include inflammatory and proliferative diseases.
摘要翻译： 本发明提供噻吩并嘧啶和噻吩并吡啶化合物及其组合物，以及其用于治疗由IRAK酶介导的疾病的方法。 这些疾病包括炎症和增殖性疾病。
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6.发明授权1-phenylpydrrolidin-2-ones and -thiones and 1-(4-pyridyl)pydrrolidin-2-ones and -thiones which are useful in the treatment of inflammatory disease 有权可用于治疗炎性疾病的1-苯基吡咯烷-2-酮和1-硫杂环戊二烯和1-（4-吡啶基）吡咯烷-2-酮和硫杂公开(公告)号：US06414153B1
公开(公告)日：2002-07-02
申请号：US09605584
申请日：2000-06-28
IPC分类号： C07D47102
CPC分类号： C07D471/04 , C07D209/34
摘要： Novel compounds of the formula I: which are useful for treating or preventing inflammatory and immune cell-mediated diseases. Exemplary compounds are: 3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-1,3-dihydroindol-2-one; 3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-3-methyl-1,3-dihydro-indol-2-one; 3-benzyl-1-(3,5-dichlorophenyl)-3-methyl-1,3-dihydroindol-2-one; 3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-4-hydroxy-3-methyl-1,3-dihydroindol-2-one; and, 3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-5-fluoro-1,3-dihydroindol-2-one.
摘要翻译： 式I的新型化合物：其可用于治疗或预防炎性和免疫细胞介导的疾病。 示例性化合物是：3-（4-溴苄基）-1-（3,5-二氯苯基）-1,3-二氢吲哚-2-酮; 3-（4-溴苄基）-1-（3,5-二氯苯基） 3-甲基-1,3-二氢 - 吲哚-2-酮; 3-苄基-1-（3,5-二氯苯基）-3-甲基-1,3-二氢吲哚-2-酮; 3-（4-溴苄基 ）-1-（3,5-二氯苯基）-4-羟基-3-甲基-1,3-二氢吲哚-2-酮; 和3-（4-溴苄基）-1-（3,5-二氯苯基）-5-氟-1,3-二氢吲哚-2-酮。
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