Heavy chain and single domain antibodies
    2.
    发明授权
    Heavy chain and single domain antibodies 失效
    重链和单结构域抗体

    公开(公告)号:US08105592B2

    公开(公告)日:2012-01-31

    申请号:US11791456

    申请日:2005-11-03

    IPC分类号: A61K35/66 A61K39/395

    摘要: The present invention relates to heavy chain immunoglobulins or fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments thereof, suitable for use in the management of infections, in particular of the gastrointestinal tract. The present invention also relates to a delivery system comprising these heavy chain immunoglobulins or functional fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments thereof, and hosts comprising expression vectors encoding for these heavy chain immunoglobulins or functional fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments thereof. The invention also relates to food products and pharmaceutical preparations comprising the delivery system, and methods for the preparation of food products according to the invention.

    摘要翻译: 本发明涉及VHH或VNAR型的重链免疫球蛋白或其片段或免疫球蛋白或其片段的重链或轻链的结构域抗体(dAb),其适用于治疗感染,特别是胃肠道 道。 本发明还涉及包含VHH或VNAR型的这些重链免疫球蛋白或其功能片段或免疫球蛋白或其片段的重链或轻链的结构域抗体(dAb)的递送系统,以及包含编码 VHH或VNAR型的这些重链免疫球蛋白或其功能片段,或免疫球蛋白或其片段的重链或轻链的结构域抗体(dAb)。 本发明还涉及包含递送系统的食品和药物制剂以及用于制备根据本发明的食品的方法。