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公开(公告)号：US07951385B2
公开(公告)日：2011-05-31
申请号：US12302067
申请日：2007-05-25
Applicant: Leon Milner Theodore Dicks , Svetoslav Dimitrov Todorov , Hendriette Knoetze , Marelize Brink
Inventor： Leon Milner Theodore Dicks , Svetoslav Dimitrov Todorov , Hendriette Knoetze , Marelize Brink
IPC: A61K39/02
CPC classification number: C12R1/46 , A61K35/744 , A61K38/00 , C07K14/315 , Y02A50/473
Abstract: The invention relates to a strain of Enterococcus mundtii having probiotic qualities. The strain of E. mundtii (ST4SA) produces an antimicrobial peptide which exhibits antimicrobial activity against a broad range of bacteria. The invention also provides an isolated nucleotide sequence which codes for the antimicrobial peptide (peptide ST4SA). Another aspect of the invention relates to a process for the production of a peptide of the invention which comprises cultivating Enterococcus mundtii strain ST4SA in a nutrient medium under micro-aerophilic conditions at a temperature of between 100 C. and 45° C., until a recoverable quantity of said peptide is produced, and recovering said peptide. The isolated peptide of the invention may be used as an antimicrobial agent in a liquid formulation or a gel formulation as a topical treatment and may also be used as an antimicrobial agent following encapsulation in a polymer.
Abstract translation: 本发明涉及具有益生菌品质的肠球菌肠杆菌菌株。 E.mundtii菌株（ST4SA）产生抗菌肽，其对广泛的细菌表现出抗微生物活性。 本发明还提供编码抗微生物肽（肽ST4SA）的分离的核苷酸序列。 本发明的另一方面涉及本发明的肽的制备方法，其包括在微环境条件下在100℃至45℃的温度下在营养培养基中培养肠球菌菌株ST4SA，直到 产生所述肽的可回收量，并回收所述肽。 本发明的分离的肽可以作为局部治疗的液体制剂或凝胶制剂中的抗微生物剂使用，并且也可以在聚合物包封之后用作抗微生物剂。
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Patent Agency Ranking
公开(公告)号：US08444998B2
公开(公告)日：2013-05-21
申请号：US13094155
申请日：2011-04-26
Applicant: Leon Milner Theodore Dicks , Svetoslav Dimitrov Todorov , Hendriette Knoetze , Marelize Brink
Inventor： Leon Milner Theodore Dicks , Svetoslav Dimitrov Todorov , Hendriette Knoetze , Marelize Brink
IPC: A61K39/02
CPC classification number: C12R1/46 , A01N63/00 , A61K38/00 , C07K14/315 , C12N1/20 , Y02A50/473
Abstract: A strain of Enterococcus mundtii has probiotic qualities. The strain of E. mundtii (ST4SA) produces an antimicrobial peptide which exhibits antimicrobial activity against a broad range of bacteria. An isolated nucleotide sequence codes for the antimicrobial peptide (peptide ST4SA). A process is also provided for the production of a peptide which comprises cultivating Enterococcus mundtii strain ST4SA in a nutrient medium under micro-aerophilic conditions at a temperature of between 10° C. and 45° C., until a recoverable quantity of the peptide is produced, and recovering the peptide. The isolated peptide may be used as an antimicrobial agent in a liquid formulation or a gel formulation as a topical treatment and may also be used as an antimicrobial agent following encapsulation in a polymer.
Abstract translation: 肠球菌菌株具有益生菌的品质。 E.mundtii菌株（ST4SA）产生抗菌肽，其对广泛的细菌表现出抗微生物活性。 分离的核苷酸序列编码抗微生物肽（肽ST4SA）。 还提供了一种用于生产肽的方法，其包括在微环境条件下在10℃至45℃的温度下在营养培养基中培养肠球菌菌株ST4SA，直到可回收量的肽为 产生并回收肽。 分离的肽可以作为局部治疗的液体制剂或凝胶制剂中的抗微生物剂使用，并且也可以在聚合物包封之后用作抗微生物剂。
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公开(公告)号：US20120325735A1
公开(公告)日：2012-12-27
申请号：US13582267
申请日：2011-02-22
Applicant: Leon Milner Theodore Dicks , Marelize Botes , Danielle Marguerite Du Plessis , Thomas Eugene Cloete , Michelle De Kwaadsteniet , Nonjabulo Diamini
Inventor： Leon Milner Theodore Dicks , Marelize Botes , Danielle Marguerite Du Plessis , Thomas Eugene Cloete , Michelle De Kwaadsteniet , Nonjabulo Diamini
CPC classification number: C02F1/002 , C02F1/003 , C02F1/283 , C02F1/444 , C02F1/50 , C02F2001/425 , C02F2305/08 , C02F2307/02 , C02F2307/06 , E03C1/08 , E03C2201/45
Abstract: A water filter assembly and water filter element are provided. The water filter element has water permeable barriers through which water is to be passed in use in order to purify same. The permeable barrier comprises a nanofibre layer defining nanopores which may be carried by a permeable support layer. The water filter element, in one form, includes an enclosure housing at least one of granular activated carbon, at least one appropriate ion exchange resin and at least one appropriate adsorbent. The nanofibers preferably have antimicrobial properties inherent thereto or provided by a biocidal agent trapped within the nanofibres or a layer thereof, or both. The water filter assembly has a perforated holder that operatively snugly receives the water filter element in a flow path through the water filter assembly. Preferably, the perforated holder has a screw threaded socket for attaching it to a container.
Abstract translation: 提供了一个水过滤器组件和水过滤元件。 水过滤器元件具有水可渗透屏障，水在其中被通过以便使其净化。 可渗透屏障包括限定纳米孔的纳米纤维层，其可以由可渗透的支撑层承载。 一种形式的水过滤元件包括容纳至少一种颗粒活性炭，至少一种合适的离子交换树脂和至少一种合适的吸附剂的外壳。 纳米纤维优选具有固有的抗微生物特性或由捕获在纳米纤维或其一层内的杀生物剂提供，或两者兼有。 水过滤器组件具有穿孔保持器，其在通过水过滤器组件的流动路径中可操作地接合水过滤器元件。 优选地，穿孔保持器具有用于将其附接到容器的螺纹插座。
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4.发明授权Baking mixes which contain flour and have an enhanced shelf life and method and means for preparing same 失效含有面粉并具有增强的保质期的烘焙混合物及其制备方法和方法公开(公告)号：US06524631B1
公开(公告)日：2003-02-25
申请号：US09937301
申请日：2001-09-25
Applicant: Leon Milner Theodore Dicks
Inventor： Leon Milner Theodore Dicks
IPC: A21D804
Abstract: A method of preparing a shelf life enhancing composition for baking mixes which contain flour with particular application to batter mixes is provided as well as a microbiological species (Lactobacillus plantarum/pentosus) used in the method. The method comprises forming a starting mixture including flour and water and inoculating same with a culture of the LPP strain micro-organisms; allowing the mixture to ferment in order to produce anti-microbial substances including lactic acid, a peptide and possibly other presently unidentified anti-microbial substances; and terminating the fermentation process and destroying all living cells prior to the pH of the mix decreasing to 3.3 to yield a shelf life enhancing composition. Baking mixes embodying the shelf life enhancing composition are also described.
Abstract translation: 提供了一种制备用于烘焙混合物的保质期提高组合物的方法，所述组合物含有特别用于面糊混合物的面粉，以及用于该方法的微生物种类（植物乳杆菌/戊酸菌）。 该方法包括形成包含面粉和水的起始混合物，并用LPP菌株微生物培养物接种; 允许混合物发酵以产生包括乳酸，肽和可能其它目前未知的抗微生物物质的抗微生物物质; 并且在混合物的pH降低至3.3之前终止发酵过程并破坏所有活细胞，以产生保质期增强组合物。 还描述了体现保质期提高组合物的烘焙混合物。
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公开(公告)号：US20110268703A1
公开(公告)日：2011-11-03
申请号：US13094155
申请日：2011-04-26
Applicant: Leon Milner Theodore Dicks , Svetoslav Dimitrov Todorov , Hendriette Knoetze , Marelize Brink
Inventor： Leon Milner Theodore Dicks , Svetoslav Dimitrov Todorov , Hendriette Knoetze , Marelize Brink
CPC classification number: C12R1/46 , A01N63/00 , A61K38/00 , C07K14/315 , C12N1/20 , Y02A50/473
Abstract: A strain of Enterococcus mundtii has probiotic qualities. The strain of E. mundtii (ST4SA) produces an antimicrobial peptide which exhibits antimicrobial activity against a broad range of bacteria. An isolated nucleotide sequence codes for the antimicrobial peptide (peptide ST4SA). A process is also provided for the production of a peptide which comprises cultivating Enterococcus mundtii strain ST4SA in a nutrient medium under micro-aerophilic conditions at a temperature of between 10° C. and 45° C., until a recoverable quantity of the peptide is produced, and recovering the peptide. The isolated peptide may be used as an antimicrobial agent in a liquid formulation or a gel formulation as a topical treatment and may also be used as an antimicrobial agent following encapsulation in a polymer.
Abstract translation: 肠球菌菌株具有益生菌的品质。 E.mundtii菌株（ST4SA）产生抗菌肽，其对广泛的细菌表现出抗微生物活性。 分离的核苷酸序列编码抗微生物肽（肽ST4SA）。 还提供了一种用于生产肽的方法，其包括在微环境条件下在10℃至45℃的温度下在营养培养基中培养肠球菌菌株ST4SA，直到可回收量的肽为 产生并回收肽。 分离的肽可以作为局部治疗的液体制剂或凝胶制剂中的抗微生物剂使用，并且也可以在聚合物包封之后用作抗微生物剂。
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公开(公告)号：US20090297482A1
公开(公告)日：2009-12-03
申请号：US12302067
申请日：2007-05-25
Applicant: Leon Milner Theodore Dicks , Svetoslav Dimitrov Todorov , Hendriette Knoetze , Marelize Brink
Inventor： Leon Milner Theodore Dicks , Svetoslav Dimitrov Todorov , Hendriette Knoetze , Marelize Brink
IPC: A61K35/74 , C07K14/315 , C12N15/31 , C12N15/74 , C12N1/21 , C12P21/02 , C12N1/36 , C07K1/107 , C07H21/04 , A61P31/04
CPC classification number: C12R1/46 , A61K35/744 , A61K38/00 , C07K14/315 , Y02A50/473
Abstract: The invention relates to a strain of Enterococcus mundtii having probiotic qualities. The strain of E. mundtii (ST4SA) produces an antimicrobial peptide which exhibits antimicrobial activity against a broad range of bacteria. The invention also provides an isolated nucleotide sequence which codes for the antimicrobial peptide (peptide ST4SA). Another aspect of the invention relates to a process for the production of a peptide of the invention which comprises cultivating Enterococcus mundtii strain ST4SA in a nutrient medium under micro-aerophilic conditions at a temperature of between 100C and 45° C., until a recoverable quantity of said peptide is produced, and recovering said peptide. The isolated peptide of the invention may be used as an antimicrobial agent in a liquid formulation or a gel formulation as a topical treatment and may also be used as an antimicrobial agent following encapsulation in a polymer.
Abstract translation: 本发明涉及具有益生菌品质的肠球菌肠杆菌菌株。 E.mundtii菌株（ST4SA）产生抗菌肽，其对广泛的细菌表现出抗微生物活性。 本发明还提供编码抗微生物肽（肽ST4SA）的分离的核苷酸序列。 本发明的另一方面涉及本发明的肽的制备方法，其包括在微环境条件下，在100℃至45℃的温度下，在营养培养基中培养肠球菌菌株ST4SA，直到可回收量 的所述肽，并回收所述肽。 本发明的分离的肽可以作为局部治疗的液体制剂或凝胶制剂中的抗微生物剂使用，并且也可以在聚合物包封之后用作抗微生物剂。
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