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    Synthesis of hydrofluoroalkanols and hydrofluoroalkenes
    1.
    发明申请
    Synthesis of hydrofluoroalkanols and hydrofluoroalkenes 有权
    氢氟烷醇和氢氟烯烃的合成

    公开(公告)号：US20090143604A1

    公开(公告)日：2009-06-04

    申请号：US12274728

    申请日：2008-11-20

    申请人： Mario Joseph Nappa ,  Xuehui Sun ,  Lev Moiseevich Yagupolskii ,  Andrey Anatolievich Filatov ,  Vladimir Nikolaevich Boiko ,  Yurii Lvovich Yagupolskii

    发明人： Mario Joseph Nappa ,  Xuehui Sun ,  Lev Moiseevich Yagupolskii ,  Andrey Anatolievich Filatov ,  Vladimir Nikolaevich Boiko ,  Yurii Lvovich Yagupolskii

    IPC分类号： C07F3/06 ,  C07C17/26 ,  C07C69/02

    CPC分类号： C07C17/00 ,  C07C17/2637 ,  C07C29/40 ,  C07C29/68 ,  C07C31/24 ,  C07C67/08 ,  C07C69/003 ,  C07F3/003 ,  C07C21/18 ,  C07C69/63 ,  C07C31/34

    摘要： Described herein is a process for the manufacture of hydrofluoroalkanols of the structure RfCFClCHROH, comprising reacting a halofluorocarbon of the structure RfCFX2, wherein each X is independently selected from Cl, Br, and I, with an aldehyde and a reactive metal in a reaction solvent to generate a reaction product comprising a metal hydrofluoroalkoxide, neutralizing said metal hydrofluoroalkoxide to produce a hydrofluoroalkanol, and recovering the hydrofluoroalkanol. Also described herein are methods of manufacturing hydrofluoroalkenes of the structure RfCF═CHR from halofluorocarbons of the structure RfCFX2, wherein each X is independently selected from Cl, Br, and I, comprising (1) reacting halofluorocarbons of the structure RfCFX2, wherein each X is independently selected from Cl, Br, and I, with an aldehyde and a reactive metal to generate a reaction product comprising a metal hydrofluoroalkoxide, and reductively dehydroxyhalogenating said metal hydrofluoroalkoxide to produce a hydrofluoroalkene or (2) reacting a hydrofluoroalkanol of the structure RfCFXCHROH or a hydrofluoroalkoxide of the structure RfCFXCHROMX, wherein M is a reactive metal in the +2 oxidation state, with a carboxylic acid anhydride and a reactive metal in a reaction solvent to form a hydrofluoroalkene and isolating the hydrofluoroalkene. In particular, 2,3,3,3,-tetrafluoro-1-propene may be manufactured with this process. Also described are compounds of the formula RfCFClCHROC(═O)R′.

    摘要翻译： 本文描述了制备结构RfCFClCHROH的氢氟烷醇的方法，包括使结构RfCFX2的卤氟烃，其中每个X独立地选自Cl，Br和I与反应溶剂中的醛和反应性金属反应 产生包含金属氢氟烷氧化物的反应产物，中和所述金属氢氟烷氧化物以产生氢氟烷醇，并回收氢氟烷醇。 本文还描述了由结构RfCFX2的卤代氟化物制备结构RfCF-CHR的氢氟烯烃的方法，其中每个X独立地选自Cl，Br和I，其包括（1）使结构RfCFX2的卤代碳氟化合物，其中每个X是 独立地选自Cl，Br和I，与醛和活性金属反应生成包含金属氢氟烷氧化物的反应产物，还原性地将所述金属氢氟烷氧化物脱羟基卤化以产生氢氟烯烃，或（2）使结构RfCFXCHROH的氢氟烷醇或 结构RfCFXCHROMX的氢氟烷氧化物，其中M是+2氧化态的活性金属，在反应溶剂中与羧酸酐和反应性金属反应形成氢氟烯烃并分离氢氟烯烃。 特别地，可以用该方法制造2,3,3,3-四氟-1-丙烯。 还描述了式RfCFClCHROC（-O）R'的化合物。

    Synthesis of hydrofluoroalkanols and hydrofluoroalkenes
    4.
    发明授权
    Synthesis of hydrofluoroalkanols and hydrofluoroalkenes 有权
    氢氟烷醇和氢氟烯烃的合成

    公开(公告)号：US08058488B2

    公开(公告)日：2011-11-15

    申请号：US12274728

    申请日：2008-11-20

    申请人： Mario Joseph Nappa ,  Xuehui Sun ,  Lev Moiseevich Yagupolskii ,  Andrey Anatolievich Filatov ,  Vladimir Nikolaevich Boiko ,  Yurii Lvovich Yagupolskii

    发明人： Mario Joseph Nappa ,  Xuehui Sun ,  Lev Moiseevich Yagupolskii ,  Andrey Anatolievich Filatov ,  Vladimir Nikolaevich Boiko ,  Yurii Lvovich Yagupolskii

    IPC分类号： C07C17/00

    CPC分类号： C07C17/00 ,  C07C17/2637 ,  C07C29/40 ,  C07C29/68 ,  C07C31/24 ,  C07C67/08 ,  C07C69/003 ,  C07F3/003 ,  C07C21/18 ,  C07C69/63 ,  C07C31/34

    摘要： Described herein is a process for the manufacture of hydrofluoroalkanols of the structure RfCFClCHROH, comprising reacting a halofluorocarbon of the structure RfCFX2, wherein each X is independently selected from Cl, Br, and I, with an aldehyde and a reactive metal in a reaction solvent to generate a reaction product comprising a metal hydrofluoroalkoxide, neutralizing said metal hydrofluoroalkoxide to produce a hydrofluoroalkanol, and recovering the hydrofluoroalkanol. Also described herein are methods of manufacturing hydrofluoroalkenes of the structure RfCF═CHR from halofluorocarbons of the structure RfCFX2, wherein each X is independently selected from Cl, Br, and I, comprising (1) reacting halofluorocarbons of the structure RfCFX2, wherein each X is independently selected from Cl, Br, and I, with an aldehyde and a reactive metal to generate a reaction product comprising a metal hydrofluoroalkoxide, and reductively dehydroxyhalogenating said metal hydrofluoroalkoxide to produce a hydrofluoroalkene or (2) reacting a hydrofluoroalkanol of the structure RfCFXCHROH or a hydrofluoroalkoxide of the structure RfCFXCHROMX, wherein M is a reactive metal in the +2 oxidation state, with a carboxylic acid anhydride and a reactive metal in a reaction solvent to form a hydrofluoroalkene and isolating the hydrofluoroalkene. In particular, 2,3,3,3,-tetrafluoro-1-propene may be manufactured with this process. Also described are compounds of the formula RfCFClCHROC(═O)R′.

    摘要翻译： 本文描述了制备结构RfCFClCHROH的氢氟烷醇的方法，包括使结构RfCFX2的卤氟烃，其中每个X独立地选自Cl，Br和I与反应溶剂中的醛和反应性金属反应 产生包含金属氢氟烷氧化物的反应产物，中和所述金属氢氟烷氧化物以产生氢氟烷醇，并回收氢氟烷醇。 本文还描述了从结构RfCFX2的卤代氟化物制备结构RfCF = CHR的氢氟烯烃的方法，其中每个X独立地选自Cl，Br和I，其包括（1）使结构RfCFX2的卤代碳氟化合物，其中每个X是 独立地选自Cl，Br和I，与醛和活性金属反应生成包含金属氢氟烷氧化物的反应产物，还原性地将所述金属氢氟烷氧化物脱羟基卤化以产生氢氟烯烃，或（2）使结构RfCFXCHROH的氢氟烷醇或 结构RfCFXCHROMX的氢氟烷氧化物，其中M是+2氧化态的活性金属，在反应溶剂中与羧酸酐和反应性金属反应形成氢氟烯烃并分离氢氟烯烃。 特别地，可以用该方法制造2,3,3,3-四氟-1-丙烯。 还描述了式RfCFClCHROC（= O）R'的化合物。