公开(公告)号：US09061076B2

公开(公告)日：2015-06-23

申请号：US12601736

申请日：2008-05-22

申请人： Stefan Franzen ,  Richard Guenther ,  Steven A. Lommel ,  LiNa Loo

发明人： Stefan Franzen ,  Richard Guenther ,  Steven A. Lommel ,  LiNa Loo

IPC分类号： A61K31/704 ,  A61P35/00 ,  A61K51/00 ,  C12N15/09 ,  A61K47/48 ,  A61K9/51 ,  B82Y5/00 ,  C12N7/00

CPC分类号： A61K47/48776 ,  A61K9/5184 ,  A61K47/6425 ,  A61K47/645 ,  A61K47/6901 ,  B82Y5/00 ,  C12N7/00 ,  C12N15/09 ,  C12N2770/38023 ,  C12N2770/38043 ,  C12N2799/02 ,  C12N2810/855

摘要： This invention is a process for the manufacture of a plant viral capsid to be used for the targeted delivery of therapeutics to diseased cells. The process uses a plant virus as the starting material. The choice of the plant virus overcomes a problem in the manufacture of a uniform starting material. The final product has an advantage over other plant virus-based delivery systems in that the plant virus selected has a natural structure that is resistant to breakdown during the delivery process. This system takes advantage of the reversible divalent cation switch that this capsid employs to assemble and disassemble.

摘要翻译： 本发明是一种用于制造用于向病变细胞靶向递送治疗剂的植物病毒衣壳的方法。 该过程使用植物病毒作为起始材料。 植物病毒的选择克服了制造均匀原料的问题。 最终产品优于其他基于植物病毒的递送系统，因为所选择的植物病毒具有在递送过程中耐破坏的天然结构。 该系统利用该衣壳用于组装和拆卸的可逆二价阳离子开关。

公开(公告)号：US20120039799A1

公开(公告)日：2012-02-16

申请号：US12601736

申请日：2008-05-22

申请人： Stefan Franzen ,  Richard Guenther ,  Steven A. Lommel ,  LiNa Loo

发明人： Stefan Franzen ,  Richard Guenther ,  Steven A. Lommel ,  LiNa Loo

IPC分类号： A61K9/00 ,  A61K31/704 ,  A61P35/00 ,  A61K51/00

CPC分类号： A61K47/48776 ,  A61K9/5184 ,  A61K47/6425 ,  A61K47/645 ,  A61K47/6901 ,  B82Y5/00 ,  C12N7/00 ,  C12N15/09 ,  C12N2770/38023 ,  C12N2770/38043 ,  C12N2799/02 ,  C12N2810/855

摘要： This invention is a process for the manufacture of a plant viral capsid to be used for the targeted delivery of therapeutics to diseased cells. The process uses a plant virus as the starting material. The choice of the plant virus overcomes a problem in the manufacture of a uniform starting material. The final product has an advantage over other plant virus-based delivery systems in that the plant virus selected has a natural structure that is resistant to breakdown during the delivery process. This system takes advantage of the reversible divalent cation switch that this capsid employs to assemble and disassemble.

摘要翻译： 本发明是一种用于制造用于向病变细胞靶向递送治疗剂的植物病毒衣壳的方法。 该过程使用植物病毒作为起始材料。 植物病毒的选择克服了制造均匀原料的问题。 最终产品优于其他基于植物病毒的递送系统，因为所选择的植物病毒具有在递送过程中耐破坏的天然结构。 该系统利用该衣壳用于组装和拆卸的可逆二价阳离子开关。