公开(公告)号：US20160158288A1

公开(公告)日：2016-06-09

申请号：US14903548

申请日：2014-07-14

申请人： Daohong ZHOU ,  Yi LUO ,  Lijian SHAO ,  Wei FENG ,  Jianhui CHANG ,  THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS

发明人： Daohong Zhou ,  Yi Luo ,  Lijian Shao ,  Wei Feng ,  Jianhui Chang

IPC分类号： A61K35/28 ,  C12N5/0789

CPC分类号： A61K35/28 ,  A61K35/15 ,  A61K2035/124 ,  C12N5/0647 ,  C12N2501/2304 ,  C12N2502/1157 ,  A61K2300/00

摘要： The invention generally features compositions and methods for expanding long term hematopoietic stem cells (HSCs) in a population of cells. In particular, the invention relates to a method of expanding long term HSCs by culturing an initial population of HSCs with macrophages that promote self-renewal of long term HSCs. The expanded cell population provides a source of cells for therapeutic treatments utilizing HSC transplantation.

摘要翻译： 本发明一般具有在细胞群中扩展长期造血干细胞（HSCs）的组合物和方法。 特别地，本发明涉及通过培养具有促进长期HSC的自我更新的巨噬细胞的初始HSC群体来扩展长期HSC的方法。 扩大的细胞群体提供了使用HSC移植治疗治疗的细胞来源。

公开(公告)号：US10137154B2

公开(公告)日：2018-11-27

申请号：US14903548

申请日：2014-07-14

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS ,  Daohong Zhou ,  Yi Luo ,  Lijian Shao ,  Wei Feng ,  Jianhui Chang

发明人： Daohong Zhou ,  Yi Luo ,  Lijian Shao ,  Wei Feng ,  Jianhui Chang

IPC分类号： A61K35/28 ,  C12N5/0789 ,  A61K35/15 ,  A61K35/12

摘要： The invention generally features compositions and methods for expanding long term hematopoietic stem cells (HSCs) in a population of cells. In particular, the invention relates to a method of expanding long term HSCs by culturing an initial population of HSCs with macrophages that promote self-renewal of long term HSCs. The expanded cell population provides a source of cells for therapeutic treatments utilizing HSC transplantation.