-
公开(公告)号:US20070192906A1
公开(公告)日:2007-08-16
申请号:US11547910
申请日:2005-04-08
申请人: Yoshikazu Yuki , Hiroshi Kiyono , Takachika Hiroi , Tomonori Nochi , Fumio Takaiwa , Hidenori Takagi , Lijyun Yang , Kazuya Suzuki , Hiroyasu Ebinuma , Koichi Sugita , Saori Kasahara
发明人: Yoshikazu Yuki , Hiroshi Kiyono , Takachika Hiroi , Tomonori Nochi , Fumio Takaiwa , Hidenori Takagi , Lijyun Yang , Kazuya Suzuki , Hiroyasu Ebinuma , Koichi Sugita , Saori Kasahara
CPC分类号: A61K39/08 , A23L7/196 , A23V2002/00 , A61K39/107 , A61K39/12 , A61K39/21 , C07K14/005 , C07K2319/55 , C12N15/8258 , C12N2740/16122 , C12N2740/16134 , A23V2300/21
摘要: To provide a transgenic rice plant that can produce rice which can be used as an “edible vaccine”, i.e., rice capable of inducing a desired immune response when mucosally administered such as an oral administration. There is provided a transgenic rice plant including a genomic DNA, wherein a DNA construct is incorporated into the genomic DNA so that the DNA construct is capable of being expressed, wherein the DNA construct includes a DNA encoding an antigenic protein, and a rice endosperm specific promoter linked upstream thereof.
摘要翻译: 提供可以产生可以用作“可食用疫苗”的水稻的转基因水稻植物,即当粘膜给药如口服给药时能够诱导所需免疫应答的水稻。 提供了包括基因组DNA的转基因水稻植物,其中将DNA构建体并入基因组DNA中,使得DNA构建体能够被表达,其中所述DNA构建体包括编码抗原蛋白的DNA和水稻胚乳特异性 启动子连接上游。