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公开(公告)号：US20070192906A1
公开(公告)日：2007-08-16
申请号：US11547910
申请日：2005-04-08
申请人： Yoshikazu Yuki , Hiroshi Kiyono , Takachika Hiroi , Tomonori Nochi , Fumio Takaiwa , Hidenori Takagi , Lijyun Yang , Kazuya Suzuki , Hiroyasu Ebinuma , Koichi Sugita , Saori Kasahara
发明人： Yoshikazu Yuki , Hiroshi Kiyono , Takachika Hiroi , Tomonori Nochi , Fumio Takaiwa , Hidenori Takagi , Lijyun Yang , Kazuya Suzuki , Hiroyasu Ebinuma , Koichi Sugita , Saori Kasahara
CPC分类号： A61K39/08 , A23L7/196 , A23V2002/00 , A61K39/107 , A61K39/12 , A61K39/21 , C07K14/005 , C07K2319/55 , C12N15/8258 , C12N2740/16122 , C12N2740/16134 , A23V2300/21
摘要： To provide a transgenic rice plant that can produce rice which can be used as an “edible vaccine”, i.e., rice capable of inducing a desired immune response when mucosally administered such as an oral administration. There is provided a transgenic rice plant including a genomic DNA, wherein a DNA construct is incorporated into the genomic DNA so that the DNA construct is capable of being expressed, wherein the DNA construct includes a DNA encoding an antigenic protein, and a rice endosperm specific promoter linked upstream thereof.
摘要翻译： 提供可以产生可以用作“可食用疫苗”的水稻的转基因水稻植物，即当粘膜给药如口服给药时能够诱导所需免疫应答的水稻。 提供了包括基因组DNA的转基因水稻植物，其中将DNA构建体并入基因组DNA中，使得DNA构建体能够被表达，其中所述DNA构建体包括编码抗原蛋白的DNA和水稻胚乳特异性 启动子连接上游。
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公开(公告)号：US20110206729A1
公开(公告)日：2011-08-25
申请号：US13126357
申请日：2009-10-30
IPC分类号： A61K39/12 , A61K39/00 , A61K39/02 , A61K39/002 , A61P37/00
CPC分类号： A61K39/08 , A61K9/0043 , A61K9/006 , A61K9/06 , A61K9/5161 , A61K39/39 , A61K47/36 , A61K47/554 , A61K47/61 , A61K47/6903 , A61K2039/541 , A61K2039/543 , A61K2039/55583 , A61K2039/6087
摘要： A mucosal vaccine for the prevention or treatment of microbial infections is described that is capable of inducing vaccine antigen-specific immune responses in an organism without the addition of a mucosal adjuvant. The mucosal vaccine comprises a composite of a nanogel comprising a hydrophilic polysaccharide having a cationic functional group and a hydrophobic cholesterol added thereto as a side chain and a vaccine antigen. The vaccine is administered via a mucosal route.
摘要翻译： 描述了用于预防或治疗微生物感染的粘膜疫苗，其能够在没有添加粘膜佐剂的情况下在生物体中诱导疫苗抗原特异性免疫应答。 粘膜疫苗包含纳米凝胶的复合物，其包含具有阳离子官能团的亲水性多糖和作为侧链加入的疏水性胆固醇作为侧链和疫苗抗原。 疫苗通过粘膜途径给药。
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3.发明授权
公开(公告)号：US5504065A
公开(公告)日：1996-04-02
申请号：US261746
申请日：1994-06-17
IPC分类号： C12N9/99 , A61K9/00 , A61K38/00 , A61K38/55 , A61P31/12 , A61P31/18 , A61P37/04 , C07K14/00 , C07K14/81 , A61K38/14 , A61K38/57
CPC分类号： A61K38/005 , Y10S530/834
摘要： Human urine trypsin inhibitor is provided as an agent for treating acquired immunodeficiency syndrome (AIDS), preventing the infection with AIDS or preventing the onset of AIDS after such infection. It can be administered intravenously for the treatment and externally for the prevention.
摘要翻译： 提供人尿胰蛋白酶抑制剂作为治疗获得性免疫缺陷综合征（AIDS）的药剂，预防感染艾滋病或预防感染后艾滋病的发病。 可以静脉内给予治疗，外用于预防。
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4.发明授权
公开(公告)号：US4479937A
公开(公告)日：1984-10-30
申请号：US524549
申请日：1983-08-19
申请人： Hiroshi Sato , Koji Sasaki , Kaname Takagi , Hajime Hiratani , Yoshikazu Yuki
发明人： Hiroshi Sato , Koji Sasaki , Kaname Takagi , Hajime Hiratani , Yoshikazu Yuki
CPC分类号： C07K14/8139
摘要： An anti-inflammatory agent comprising as an active component an inhibitor specifically inhibiting a thiol protease, which is obtained from human urine by extraction and purification. This agent has an action of inhibiting a disease caused by a thiol protease. This anti-inflammatory agent is prepared by a process in which a thiol protease inhibitor is extracted and purified from human urine by adopting in combination at least two treatments selected from a treatment with a molecular filter, a treatment with an ion exchanger, a treatment with an adsorber and an affinity chromatographic treatment.
摘要翻译： 一种抗炎剂，其包含通过提取和纯化从人尿获得的特异性抑制硫醇蛋白酶的抑制剂作为活性成分。 该药剂具有抑制由硫醇蛋白酶引起的疾病的作用。 该抗炎剂通过以下方法制备，其中通过组合使用选自以下的至少两种处理组合提取和纯化巯基蛋白酶抑制剂：选自用分子过滤器处理，用离子交换剂处理，用离子交换剂处理， 吸附剂和亲和色谱处理。
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公开(公告)号：US5371196A
公开(公告)日：1994-12-06
申请号：US115458
申请日：1993-09-01
申请人： Yoshikazu Yuki , Motoko Baba , Mitsuo Shimizu , Kazuo Kato , Hajime Hiratani
发明人： Yoshikazu Yuki , Motoko Baba , Mitsuo Shimizu , Kazuo Kato , Hajime Hiratani
CPC分类号： C07K16/04 , A61L2/0023 , A61K38/00 , Y10S530/861
摘要： Secretory immunoglobulin A preparations substantially not containing virus are produced by a process wherein secretory immunoglobulin A which might be contaminated with viruses is (1) heated about 60.degree. C. for about 10 hours, or (2) subjected to the reaction with tri-n-butyl phosphate and a surfactant and the heating as mentioned above, as liquidized form in an aqueous medium, and then polymerized matters are precipitated from the resulting solution by adding polyethyleneglycol thereto.
摘要翻译： 分泌型免疫球蛋白基本上不含病毒的制剂通过其中可能被病毒污染的分泌型免疫球蛋白A（1）加热约60℃约10小时的方法产生，或（2）与三硝基苯甲酸反应 磷酸丁酯和表面活性剂，并且如上所述的加热，在水性介质中作为液化形式，然后通过向其中加入聚乙二醇从所得溶液中沉淀出聚合物质。
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公开(公告)号：US4665161A
公开(公告)日：1987-05-12
申请号：US857511
申请日：1986-04-21
IPC分类号： A61K35/22 , A61K38/24 , A61P5/00 , C07K1/30 , C07K14/435 , C07K14/575 , C07K14/59 , C07K14/61 , C07K3/12
CPC分类号： C07K14/59
摘要： Crude HCG is purified by extracting with a neutral or weakly basic aqueous solution containing lower aliphatic alcohol and soluble salt, adding lower aliphatic alcohol to the extracted solution to form precipitates and the precipitates containing high purity of HCG are collected. This precipitates can be further purified by dissolving in a buffer solution, contacting the solution with a weak anion exchanger and eluting the exchanger with said buffer solution containing added salt.
摘要翻译： 通过用含有低级脂肪醇和可溶性盐的中性或弱碱性水溶液提取粗提HCG，向提取的溶液中加入低级脂族醇形成析出物，并收集含有高纯度HCG的沉淀物。 该沉淀物可以通过溶解在缓冲溶液中进一步纯化，使溶液与弱阴离子交换剂接触并用含有加入的盐的缓冲溶液洗脱交换器。
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公开(公告)号：US5315376A
公开(公告)日：1994-05-24
申请号：US774816
申请日：1991-10-11
申请人： Akio Wada , Mitsuo Watanabe , Yoshikazu Yuki , Kazunori Ebisawa , Masashi Nishimoto , Kazuhisa Hayashi , Kiyoharu Kutsuna , Takehito Mizutani
发明人： Akio Wada , Mitsuo Watanabe , Yoshikazu Yuki , Kazunori Ebisawa , Masashi Nishimoto , Kazuhisa Hayashi , Kiyoharu Kutsuna , Takehito Mizutani
CPC分类号： G01N21/274
摘要： A concentration correcting apparatus comprising a correction coefficient calculating means and a correcting means is shown and described. The correction coefficient calculating means calculates a correction coefficient for correcting the concentration of the material when the actual density of the medium at the measurement of the material is calculated in terms of the density of the medium under the reference temperature and pressure, from the results of the temperature measuring means and the pressure measuring means. The correcting means corrects the results of the material measuring means to a concentration under the reference temperature and pressure on the basis of the correction coefficient. The measure value of the material in the medium under constant temperature and depressure is virtually calculated by correcting the measured value by using the correction coefficient while calculating the volume of the medium which is regarded as a parameter of a temperature and a pressure in terms of a volume under the constant temperature and pressure. It is therefore possible to calculate the concentration per unit weight under constant conditions even if the temperature and the pressure are varied at the time of measurement.
摘要翻译： 示出并描述了包括校正系数计算装置和校正装置的浓度校正装置。 校正系数计算装置根据介质在基准温度和压力下的密度计算材料测量时的介质的实际密度，计算出用于校正材料浓度的校正系数， 温度测量装置和压力测量装置。 校正装置基于校正系数将材料测量装置的结果校正为在参考温度和压力下的浓度。 通过在计算被认为是温度和压力的参数的介质的体积的同时使用校正系数来校正测量值，实际上计算了在恒温和低压下介质中的材料的测量值 体积恒温恒压。 因此，即使温度和压力在测量时变化，也可以在恒定条件下计算每单位重量的浓度。
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8.发明授权Process for concentrating and separating trypsin inhibitor and kallidinogenase in human urine 失效浓缩和分离人尿中胰蛋白酶抑制剂和杀鼠肽素酶的方法
公开(公告)号：US4780209A
公开(公告)日：1988-10-25
申请号：US104634
申请日：1987-10-02
CPC分类号： C12N9/6445 , C07K14/8114 , Y10S435/814 , Y10S435/815
摘要： Two components, trypsin and kallidinogenase, in human urine are concentrated simultaneously by allowing human urine at neutral pH, collecting bubbles thus formed to obtain the concentrate of the two components, adjusting the concentrate to weak acidity, contacting the acidified concentrate with chitosan to allow the two components to be adsorbed onto chitosan, eluting the components from the adsorbent with aqueous ammonia solution, and neutralizing and heating the eluate at about 60.degree. C. for about 10 hours to make the eluate virus-free, followed by separating the components from the eluate.
摘要翻译： 将人尿中的两种成分，胰蛋白酶和杀鼠肽素酶同时浓缩，使人尿液处于中性pH值，收集形成的气泡，得到两种成分的浓缩物，将浓缩物调节至弱酸性，将酸化浓缩物与壳聚糖接触， 吸附在壳聚糖上的两种组分，用氨水溶液从吸附剂中洗脱组分，并在约60℃下中和并加热洗脱液约10小时，使洗脱液无病毒，然后将组分从 洗脱液
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