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公开(公告)号：US08158857B2
公开(公告)日：2012-04-17
申请号：US12751869
申请日：2010-03-31
Applicant: Ning Huang , Raymond L. Rodriguez , Frank E. Hagie , David M. Stalker
Inventor： Ning Huang , Raymond L. Rodriguez , Frank E. Hagie , David M. Stalker
IPC: C12N15/82 , A01H5/00 , A23J3/18 , C07K4/12 , C07K14/765
CPC classification number: G01N33/57492 , A23K10/30 , A23K20/147 , A23L7/198 , A23L7/20 , A23L33/105 , A23L33/19 , A23V2002/00 , B82Y30/00 , C07K14/415 , C07K14/485 , C07K14/65 , C07K14/79 , C07K14/8125 , C12N9/0065 , C12N9/2462 , C12N15/8216 , C12N15/8222 , C12N15/8234 , C12N15/8257 , G01N33/57484 , G01N2333/4725 , G01N2500/02 , A23V2300/21
Abstract: The invention is directed to monocot plant seed products comprising human serum albumin, and to methods of making said monocot plant seed products comprising human serum albumin and to therapeutic compositions comprising them.
Abstract translation: 本发明涉及包含人血清白蛋白的单子叶植物种子产品，以及制备包含人血清白蛋白的所述单子叶植物种子产品的方法和包含它们的治疗组合物的方法。
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2.发明授权Modified amylases from pseudomonas species, methods of making and uses thereof 有权来自假单胞菌种的修饰的淀粉酶，其制备方法和用途公开(公告)号：US08137944B2
公开(公告)日：2012-03-20
申请号：US11887977
申请日：2005-07-07
Applicant: Casper Tune Berg , Patrick M. F. Derkx , Carol Fioresi , Gijsbert Gerritse , Anja Hemmingen Kellet-Smith , Karsten Matthias Kragh , Wei Liu , Andrew Shaw , Bo Spange Sørensen , Charlotte Refdahl Thoudahl
Inventor： Casper Tune Berg , Patrick M. F. Derkx , Carol Fioresi , Gijsbert Gerritse , Anja Hemmingen Kellet-Smith , Karsten Matthias Kragh , Wei Liu , Andrew Shaw , Bo Spange Sørensen , Charlotte Refdahl Thoudahl
IPC: C12N9/28 , C12N9/26 , C12N9/24 , C12N9/00 , C12P21/06 , A21D2/00 , A23C17/00 , A23L1/08 , A23K3/00 , A23K3/08 , C07H21/04 , C07K1/00
CPC classification number: C12Y302/0106 , A21D8/042 , A23K20/189 , A23L7/107 , A23L29/35 , A23V2002/00 , C12N9/2417 , A23V2300/21
Abstract: Variant polypeptides derivable from a parent polypeptide having non-maltogenic exoamylase activity, in which the variant polypeptides comprise an amino acid mutation at one or more positions selected from the group consisting of: 121, 161, 223, 146, 157, 158, 198, 229, 303, 306, 309, 316, 353, 26, 70, 145, 188, 272, 339, with reference to the position numbering of a Pseudomonas saccharophila exoamylase sequence shown as SEQ ID NO: 1.
Abstract translation: 衍生自具有非麦芽糖外切酶活性的亲本多肽的变体多肽，其中所述变体多肽在选自以下的一个或多个位置包含氨基酸突变：121,161,223,146,157,158,199， 229,303,306,309,316,353,26,70,105,188,272,339，参考如SEQ ID NO：1所示的糖酵母假单胞菌外切酶序列的位置编号。
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3.发明申请MODIFIED AMYLASES, NUCLEIC ACIDS ENCODING THOSE AMYLASES AND USES THEREOF 有权改性AMYLASES，核酸编码其中的AMYLASES及其用途公开(公告)号：US20110212241A1
公开(公告)日：2011-09-01
申请号：US13023061
申请日：2011-02-08
Applicant: Karsten Matthias Kragh , Bo Spange Sørensen , Casper Tune Berg , Kirsten Bojsen , Patrick M.F. Derkx , Carol Fioresi , Anja H. Kellett-Smith , Charlotte Refdahl Thoudahl , Oene R. Veltman , Gijsbert Gerritse , Wei Liu , Andrew Shaw
Inventor： Karsten Matthias Kragh , Bo Spange Sørensen , Casper Tune Berg , Kirsten Bojsen , Patrick M.F. Derkx , Carol Fioresi , Anja H. Kellett-Smith , Charlotte Refdahl Thoudahl , Oene R. Veltman , Gijsbert Gerritse , Wei Liu , Andrew Shaw
CPC classification number: C12N9/2417 , A21D8/042 , A23L29/06 , A23L29/35 , A23L33/17 , A23V2002/00 , A23V2300/21
Abstract: This invention relates to nucleic acids encoding amylase polypeptides, the encoded polypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial qualities. Specifically, the amylases of the current invention show an altered exo-specificity and/or thermostability. Some embodiments of the invention relate to said polypeptides and nucleic acids and their uses as non-maltogenic exoamylases in producing food products.
Abstract translation: 本发明涉及编码淀粉酶多肽的核酸，编码的多肽及其用途。 本发明的淀粉酶已被设计成具有更多的有益品质。 具体地，本发明的淀粉酶显示出改变的外部特异性和/或热稳定性。 本发明的一些实施方案涉及所述多肽和核酸及其在制备食品中的非麦芽糖胞外淀粉酶的用途。
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4.发明申请PLANT CELLS AND PLANTS WHICH SYNTHESIZE A STARCH WITH AN INCREASED FINAL VISCOSITY 有权植物细胞和植物合成具有增加的最终粘度的淀粉公开(公告)号：US20100292461A1
公开(公告)日：2010-11-18
申请号：US12714167
申请日：2010-02-26
Applicant: Michaela Hoehne , Claus Frohberg , Volker Landschuetze
Inventor： Michaela Hoehne , Claus Frohberg , Volker Landschuetze
IPC: C08B31/00
CPC classification number: C12N15/8245 , A23L29/212 , A23V2002/00 , C12N9/1051 , C12N9/107 , A23V2300/21
Abstract: The present invention relates to a plant cell which is genetically modified, the genetic modification leading to the reduction of the activity of one or more SSIII proteins which occur endogenously in the plant cell and to the reduction of the activity of one or more BEI proteins which occur endogenously in the plant cell and to the reduction of the activity of one or more BEII proteins which occur endogenously in the plant cell in comparison with corresponding plant cells, of wild-type plants, which have not been genetically modified. Further aspects of the invention relate to plants containing such plant cells, to a method for generating the plant cells and plants, and to the starch obtainable from them.
Abstract translation: 本发明涉及遗传修饰的植物细胞，导致在植物细胞中内源性发生的一种或多种SSIII蛋白的活性降低的遗传修饰以及降低一种或多种BEI蛋白的活性， 在植物细胞中内源性地发生，并且与未经遗传修饰的野生型植物的相应植物细胞相比，在植物细胞内源性地发生一种或多种BEII蛋白的活性降低。 本发明的其它方面涉及含有这种植物细胞的植物，用于产生植物细胞和植物的方法以及从其获得的淀粉。
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公开(公告)号：US07790955B2
公开(公告)日：2010-09-07
申请号：US10577564
申请日：2004-10-27
Applicant: Zhongyi Li , Matthew Kennedy Morell , Sadequr Rahman
Inventor： Zhongyi Li , Matthew Kennedy Morell , Sadequr Rahman
CPC classification number: C12N9/107 , A23L7/196 , A23L7/198 , A23L29/212 , A23V2002/00 , C12N15/8245 , A23V2300/21
Abstract: Rice having reduced levels of starch branching enzymes produce grain having a high relative amylose content in the endosperm. The rice grain of this invention can be of a non-shrunken phenotype despite a lesion in the amylopectin synthesis pathway and may be transgenic or nontransgenic. 1 GCCACCGACA TCCGCCGCAA TGCTGTGTCT CACCTCCTCT TCCTCCTCCG CGCCCGCTCC 61 GCTCCTTCCC TCTCTCGCTG ATCGACCGAG CCCGGGAATC GCGGGCGGGG GTGGCAATGT 121 TCGCCTGAGC GTGGTTTCTT CGCCGCGCCG GTCGTGGCCT GGAAAGGTCA AGACCAATTT 181 CTCAGTTCCT GCGACTGCGC GAAAAAACAA AACCATGGTG ACTGTTGTGG AGGAGGTCGA 241 CCACCTTCCT ATATATGATC TGGACCCTAA GTTGGAGGAA TTCAAGGATC ACTTCAACTA 301 TAGGATAAAA AGATACCTCG ACCAGAAATG CCTGATTGAA AAACATGAGG GGGGCCTTGA 361 AGAATTTTCT AAAGGCTATT TGAAGTTTGG GATTAATACA GTTGATGGTG CCACAATATA 421 TCGTGAATGG GCGCCTGCTG CACAAGAAGC ACAGCTCATT GGTGAGTTCA ATAACTGGAA 481 TGGTGCAAAA CACAAGATGG AGAAGGATAA ATTTGGCATT TGGTCAATCA AGATTTCACA 541 TGTCAATGGG AAGCCTGCCA TCCCTCACAA TTCCAAGGTT AAATTTCGCT TTAGGCATGG 601 GGGTGGAGCA TGGGTTGATC GTATTCCCGC ATGGATTCGT TATGCAACTT TTGATGCCTC 661 TAAATTTGGA GCTCCATATG ATGGTGTACA CTGGGATCCT CCAGCCTGTG AAAGGTACGT 721 GTTTAAGCAT CCTCGACCTC CAAAACCTGA TGCTCCACGC ATCTATGAGG CTCATGTGGG 781 GATGAGTGGT GAAGAGCCAG AAGTAAGCAC ATACAGAGAA TTTGCAGACA ATGTGTTACC 841 ACGCATACGG GCAAATAACT ACAACACAGT TCAGTTAATG GCAATCATGG AACATTCCTA 901 CTATGCTTCT TTTGGGTATC ACGTGACAAA TTTTTTCGCA GTCAGCAGCA GATCAGGAAC 961 ACCAGAGGAT CTGAAATATC TTGTTGACAA GGCACATAGT TTAGGATTAC GAGTTCTGAT 1021 GGATGTTGTC CATAGCCATG CGAGTAATAA TGTGACCGAT GGTCTAAATG GCTATGACGT 1081 TGGACAAAAC ACTCATGAGT CTTATTTTCA TACAGGAGAT AGGGGCTACC ATAAACTCTG 1141 GGATAGTCGT CTGTTCAACT ATGCCAATTG GGAGGTCTTA AGATTTCTTC TTTCTAATTT 1201 GAGATATTGG ATGGACGAAT TCATGTTTGA TGGCTTCCGA TTTGATGGGG TTACATCAAT 1261 GCTATACCAT CACCATGGTA TCAATAAGGG ATTTACTGGA AACTACAAGG AGTATTTCAG 1321 TTTGGATACC GATGTGGATG CAATTGTTTA CATGATGCTC GCAAACCATT TAATGCATAA 1381 ACTCTTGCCG GAAGCAACTA TTGTTGCTGA AGATGTTTCG GGCATGCCAG TGCTTTGTCG 1441 GCCAGTTGAT GAAGGTGGAG TAGGGTTTGA CTTCCGCCTG GCAATGGCCA TTCCTGATAG 1501 ATGGATTGAC TACCTGAAGA ACAAAGAGGA CCGCAAATGG TCAATGAGTG AAATAGTGCA 1561 AACTTTGACT AACAGGAGAT ATACAGAAAA ATGCATTGCC TATGCCGAGA GCCATGATCA 1621 GTCCATTGTT GGTGACAAGA CTATAGCATT TCTCTTGATG GACAAGGAAA TGTACACTGG 1681 CATGTCAGAC TTGCAGCCTG CTTCACCTAC CATCAACCGT GGCATTGCAC TCCAAAAGAT 1741 GATTCACTTC ATTACGATGG CCCTTGGAGG TGATGGCTAC TTAAATTTTA TGGGCAATGA 1801 GTTTGGCCAT CCAGAATGGA TTGACTTTCC AAGAGAAGGC AACAACTGGA GCTATGATAA 1861 ATGCAGACGT CAGTGGAGCC TTGTCGACAC TGATCACCTT CGATACAAGT ATATGAATGC 1921 ATTTGATCAA GCAATGAATG CACTCGAGGA GGAATTTTCC TTCCTGTCAT CATCAAAGCA 1981 GATTGTTAGC GACATGAACG AGAAAGATAA GGTTATTGTC TTTGAACGTG GAGATTTGGT 2041 TTTTGTTTTC AATTTTCATC CCAACAAAAC TTATAAGGGT TACAAAGTCG GATGTGACTT 2101 GCCCGGGAAG TACAGAGTAG CTCTGGACTG TGATGCTTTG GTCTTTGGTG GCCATGGAAG 2161 AGTTGGCCAT GATGTGGATC ACTTCACGTC TCCCGAGGGA ATGCCAGGAG TACCAGAAAC 2221 AAATTTCAAC AACCGCCCTA ACTCATTCAA AGTCCTTTCC CCGCCCCGTA CCTGTGTGGC 2281 TTACTATCGC GTTGATGAAG ATCGTGAAGA GCTCAGGAGG GGTGGAGCAG TTGCTTCTGG 2341 AAAGATTGTT ACAGAGTATA TCGATGTTGA AGCAACAAGT GGGGAGACTA TCTCTGGTGG 2401 CTGGAAGGGC TCCGAGAAGG ACGATTGTGG CAAGAAAGGG ATGAAGTTTG TGTTTCGGTC 2461 TTCTGACGAA GACTGCAAAT GAAGCATCAG ATTTCTTGAT CAGGAGCAAC TGTTGGTGCC 2521 CTTGTAATCT GGAGATCCTG GCTTGCCTTG GACTTGGTTG TGGTTCTTTA GCAGTTGCTA 2581 TGTACCTATC TATGATATGA ACTTTATGTA TAGTTCGCCT TAAAGAAAGA ATAAGCAGTG 2641 ATGATGTGGC CTTAAACCTG AGCTGCACAA GCCTAATGTA AAAATAAAGT TTCAGGCTTT 2701 CATCCAGAAT AAAACAGCTG TTCATTTACC ATCTCAAAA
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Patent Agency Ranking
公开(公告)号：US07718851B2
公开(公告)日：2010-05-18
申请号：US12148779
申请日：2008-04-21
Applicant: Ning Huang , Raymond L. Rodriguez , Frank E. Hagie
Inventor： Ning Huang , Raymond L. Rodriguez , Frank E. Hagie
CPC classification number: G01N33/57492 , A23K10/30 , A23K20/147 , A23L7/198 , A23L7/20 , A23L33/105 , A23L33/19 , A23V2002/00 , B82Y30/00 , C07K14/415 , C07K14/485 , C07K14/65 , C07K14/79 , C07K14/8125 , C12N9/0065 , C12N9/2462 , C12N15/8216 , C12N15/8222 , C12N15/8234 , C12N15/8257 , G01N33/57484 , G01N2333/4725 , G01N2500/02 , A23V2300/21
Abstract: The invention is directed to seed and seed extract compositions containing levels of a human milk protein between 3-40% or higher of the total protein weight of the soluble protein extractable from the seed. Also disclosed is a method of producing the seed with high levels of extractable human milk protein. The method includes transforming a monocotyledonous plant with a chimeric gene having a protein-coding sequence encoding a protein normally present in human milk under the control of a seed maturation-specific promoter. The method may further includes a leader DNA sequence encoding a monocot seed-specific transit sequence capable to target a linked milk protein to a storage body.
Abstract translation: 本发明涉及种子和种子提取物组合物，其含有可从种子中提取的可溶性蛋白质的总蛋白重量的3-40％或更高的人乳蛋白质含量。 还公开了一种生产高水平可提取人乳蛋白的种子的方法。 该方法包括用嵌合基因转化单子叶植物，所述嵌合基因具有编码在种子成熟特异性启动子控制下通常存在于人乳中的蛋白质的蛋白质编码序列。 该方法还可以包括编码能够将连接的乳蛋白靶向存储体的单子叶种子特异性转运序列的前导DNA序列。
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7.发明申请DELTA-8 DESATURASE AND ITS USE IN MAKING POLYUNSATURATED FATTY ACIDS 审中-公开DELTA-8去饱和酶及其在制备多糖脂肪酸中的用途公开(公告)号：US20090264666A1
公开(公告)日：2009-10-22
申请号：US12431813
申请日：2009-04-29
Applicant: Howard Glenn Damude , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Quinn Qun Zhu
CPC classification number: C12P7/6472 , A23D9/00 , A23K20/158 , A23L33/12 , A23V2002/00 , C12N9/0083 , C12N15/8247 , C12P7/6427 , A23V2300/21
Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding a delta-8 desaturase along with a method of making long chain polyunsaturated fatty acids (PUFAs) using this delta-8 desaturase in plants and oleaginous yeast.
Abstract translation: 分离的核酸片段和包含编码Δ-8去饱和酶的片段的重组构建物以及使用该植物中的δ-8去饱和酶和油质酵母制备长链多不饱和脂肪酸（PUFA）的方法。
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公开(公告)号：US20090258004A1
公开(公告)日：2009-10-15
申请号：US11987053
申请日：2007-11-27
Applicant: Ning Huang , Raymond L. Rodriquez , Frank E. Hagie , David M. Stalker
Inventor： Ning Huang , Raymond L. Rodriquez , Frank E. Hagie , David M. Stalker
IPC: A61K39/395 , C07K14/47 , C07K14/75 , C07K14/765 , C12N9/74 , C07K14/745 , C07K16/00 , A61K38/16 , A61K38/42 , A61K38/48 , A61K38/14 , A61K38/36 , A61P7/00
CPC classification number: G01N33/57492 , A23K10/30 , A23K20/147 , A23L7/198 , A23L7/20 , A23L33/105 , A23L33/19 , A23V2002/00 , B82Y30/00 , C07K14/415 , C07K14/485 , C07K14/65 , C07K14/79 , C07K14/8125 , C12N9/0065 , C12N9/2462 , C12N15/8216 , C12N15/8222 , C12N15/8234 , C12N15/8257 , G01N33/57484 , G01N2333/4725 , G01N2500/02 , A23V2300/21
Abstract: The invention is directed to blood proteins produced in monocot seeds and isolated therefrom for use in therapeutic compositions, and to methods of making these isolated blood proteins and to therapeutic compositions comprising them.
Abstract translation: 本发明涉及在单子叶植物中产生并从其分离用于治疗组合物中的血液蛋白质，以及制备这些分离的血液蛋白质的方法以及包含它们的治疗组合物。
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9.发明授权公开(公告)号：US07550651B2
公开(公告)日：2009-06-23
申请号：US11166003
申请日：2005-06-24
Applicant: Howard G. Damude
Inventor： Howard G. Damude
CPC classification number: C12P7/6472 , A23D9/00 , A23K20/158 , A23L33/12 , A23V2002/00 , C12N9/0083 , C12N15/8247 , C12P7/6427 , A23V2300/21
Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding a delta-8 desaturase along with a method of making long chain polyunsaturated fatty acids (PUFAs) using this delta-8 desaturase in plants and oleaginous yeast.
Abstract translation: 分离的核酸片段和包含编码Δ-8去饱和酶的片段的重组构建物以及使用该植物中的δ-8去饱和酶和油质酵母制备长链多不饱和脂肪酸（PUFA）的方法。
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公开(公告)号：US20080248188A1
公开(公告)日：2008-10-09
申请号：US11585179
申请日：2006-10-24
Applicant: Gabi Schewe , Petra Knies , Simone Franceska Amati , Horst Lorz , Dirk Becker , Volker Landschutze , Jens Pilling
Inventor： Gabi Schewe , Petra Knies , Simone Franceska Amati , Horst Lorz , Dirk Becker , Volker Landschutze , Jens Pilling
CPC classification number: A21D2/186 , A23L7/198 , A23L29/212 , A23V2002/00 , C07K14/415 , C08B30/00 , C12N9/00 , C12N15/8245 , A23V2300/21
Abstract: The present invention relates to monocotyledon plant cells and plants which are genetically modified, wherein the genetic modification consists of the introduction of an extraneous nucleic acid molecule which codes for a protein with the biological activity of an R1 protein. The present invention further relates to means and methods for the production thereof. Plant cells and plants of this type synthesise a modified starch, which is characterised in that it has an increased phosphate content and/or a modified phosphorylation pattern and/or an increased final viscosity in an RVA profile and/or a reduced peak temperature in DSC analysis and/or an increased gel strength in the texture analysis compared with starch from corresponding non-genetically modified monocotyledon plants. Therefore, the present invention also relates to the starch which is synthesised from the plant cells and plants according to the invention, and to methods of producing said starch. The present invention further relates to wheat flours which contain said modified starches, and to food products and bakery products which contain said wheat flours and/or starch.
Abstract translation: 本发明涉及单子叶植物细胞和遗传修饰的植物，其中遗传修饰由引入编码具有R1蛋白的生物活性的蛋白质的外来核酸分子组成。 本发明还涉及其生产方法和方法。 这种类型的植物细胞和植物合成了改性淀粉，其特征在于其具有增加的磷酸盐含量和/或改进的磷酸化模式和/或在RVA谱中增加的最终粘度和/或DSC中降低的峰值温度 分析和/或纹理分析中与来自相应的非转基因植物单子叶植物的淀粉相比增加的凝胶强度。 因此，本发明还涉及由根据本发明的植物细胞和植物合成的淀粉以及生产所述淀粉的方法。 本发明还涉及含有所述改性淀粉的小麦粉，以及含有所述小麦面粉和/或淀粉的食品和焙烤食品。
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