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公开(公告)号：US20240247016A1
公开(公告)日：2024-07-25
申请号：US18434560
申请日：2024-02-06
IPC分类号： C07F9/6584 , C07F9/6578
CPC分类号： C07F9/65848 , C07F9/65785
摘要： Disclosed herein are cyclic thiol prodrugs, and pharmaceutical compositions thereof. The prodrugs and pharmaceutical compositions thereof may be used to treat or prevent medical disorders such as, for example, cystinuria, cystinosis, cancer, neurodegenerative disease, Parkinson's disease, Huntington's disease, malaria, nonalcoholic fatty liver disease, radiation poisoning, arsenic poisoning, radioprotection, Wilson's disease or rheumatoid arthritis.
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公开(公告)号：US11806335B2
公开(公告)日：2023-11-07
申请号：US17081940
申请日：2020-10-27
发明人： Hongyan Guo , Amy S. Lee , Hyung-Jung Pyun , Devleena M. Shivakumar , Manoj C. Desai , Lianhong Xu , John E. Knox , Zachary E R Newby
IPC分类号： A61K31/4192 , A61K31/19 , A61K31/194 , A61K31/351 , A61K31/381 , A61K31/382 , A61K31/415 , A61K31/4164 , A61K31/422 , A61K31/427 , A61K31/428 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/675 , A61K31/7048 , A61K38/51 , A61K45/06 , C07D231/14 , C07D233/90 , C07D249/06 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/10 , C07D405/14 , C07D413/10 , C07D417/04 , C07D417/10 , C07F9/6558 , C12N15/113
CPC分类号： A61K31/4192 , A61K31/19 , A61K31/194 , A61K31/351 , A61K31/381 , A61K31/382 , A61K31/415 , A61K31/4164 , A61K31/422 , A61K31/427 , A61K31/428 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/675 , A61K31/7048 , A61K38/51 , A61K45/06 , C07D231/14 , C07D233/90 , C07D249/06 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/10 , C07D405/14 , C07D413/10 , C07D417/04 , C07D417/10 , C07F9/65583 , C12N15/113 , C12N2310/14
摘要： The present disclosure relates generally to modulators of human glycolate oxidase enzyme and methods of use and manufacture thereof.
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公开(公告)号：US20230212200A1
公开(公告)日：2023-07-06
申请号：US18147172
申请日：2022-12-28
摘要： Disclosed herein are acyclic thiol prodrugs, and pharmaceutical compositions thereof. The prodrugs and pharmaceutical compositions thereof may be used to treat or prevent medical disorders such as, for example cystinosis, cystinuria, cancer neurodegenerative disease, Parkinson's disease, Huntington's disease, malaria, nonalcoholic fatty liver disease, radiation poisoning, arsenic poisoning, radioprotection, Wilson's disease or rheumatoid arthritis.
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公开(公告)号：US20240270767A1
公开(公告)日：2024-08-15
申请号：US18632991
申请日：2024-04-11
IPC分类号： C07F9/202 , A61K31/145 , A61P39/00 , C07F9/165 , C07F9/203
CPC分类号： C07F9/202 , A61K31/145 , A61P39/00 , C07F9/1651 , C07F9/203
摘要： Disclosed herein are acyclic thiol prodrugs, and pharmaceutical compositions thereof. The prodrugs and pharmaceutical compositions thereof may be used to treat or prevent medical disorders such as, for example cystinosis, cystinuria, cancer neurodegenerative disease, Parkinson's disease, Huntington's disease, malaria, nonalcoholic fatty liver disease, radiation poisoning, arsenic poisoning, radioprotection, Wilson's disease or rheumatoid arthritis.
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公开(公告)号：US11932665B2
公开(公告)日：2024-03-19
申请号：US18147178
申请日：2022-12-28
IPC分类号： C07F9/6578 , C07F9/6584
CPC分类号： C07F9/65848 , C07F9/65785
摘要： Disclosed herein are cyclic thiol prodrugs, and pharmaceutical compositions thereof. The prodrugs and pharmaceutical compositions thereof may be used to treat or prevent medical disorders such as, for example, cystinuria, cystinosis, cancer, neurodegenerative disease, Parkinson's disease, Huntington's disease, malaria, nonalcoholic fatty liver disease, radiation poisoning, arsenic poisoning, radioprotection, Wilson's disease or rheumatoid arthritis.
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公开(公告)号：US20230234979A1
公开(公告)日：2023-07-27
申请号：US18147178
申请日：2022-12-28
IPC分类号： C07F9/6584 , C07F9/6578
CPC分类号： C07F9/65848 , C07F9/65785
摘要： Disclosed herein are cyclic thiol prodrugs, and pharmaceutical compositions thereof. The prodrugs and pharmaceutical compositions thereof may be used to treat or prevent medical disorders such as, for example, cystinuria, cystinosis, cancer, neurodegenerative disease, Parkinson’s disease, Huntington’s disease, malaria, nonalcoholic fatty liver disease, radiation poisoning, arsenic poisoning, radioprotection, Wilson’s disease or rheumatoid arthritis.
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公开(公告)号：US11981694B2
公开(公告)日：2024-05-14
申请号：US18147172
申请日：2022-12-28
IPC分类号： C07F9/202 , A61K31/145 , A61P39/00 , C07F9/165 , C07F9/203
CPC分类号： C07F9/202 , A61K31/145 , A61P39/00 , C07F9/1651 , C07F9/203
摘要： Disclosed herein are acyclic thiol prodrugs, and pharmaceutical compositions thereof. The prodrugs and pharmaceutical compositions thereof may be used to treat or prevent medical disorders such as, for example cystinosis, cystinuria, cancer neurodegenerative disease, Parkinson's disease, Huntington's disease, malaria, nonalcoholic fatty liver disease, radiation poisoning, arsenic poisoning, radioprotection, Wilson's disease or rheumatoid arthritis.
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公开(公告)号：US20240091200A1
公开(公告)日：2024-03-21
申请号：US18373505
申请日：2023-09-27
发明人： Hongyan Guo , Amy S. Lee , Hyung-Jung Pyun , Devleena M. Shivakumar , Manoj C. Desai , Lianhong Xu , John E. Knox , Zachary ER Newby
IPC分类号： A61K31/4192 , A61K31/19 , A61K31/194 , A61K31/351 , A61K31/381 , A61K31/382 , A61K31/415 , A61K31/4164 , A61K31/422 , A61K31/427 , A61K31/428 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/675 , A61K31/7048 , A61K38/51 , A61K45/06 , C07D231/14 , C07D233/90 , C07D249/06 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/10 , C07D405/14 , C07D413/10 , C07D417/04 , C07D417/10 , C07F9/6558 , C12N15/113
CPC分类号： A61K31/4192 , A61K31/19 , A61K31/194 , A61K31/351 , A61K31/381 , A61K31/382 , A61K31/415 , A61K31/4164 , A61K31/422 , A61K31/427 , A61K31/428 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/675 , A61K31/7048 , A61K38/51 , A61K45/06 , C07D231/14 , C07D233/90 , C07D249/06 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/10 , C07D405/14 , C07D413/10 , C07D417/04 , C07D417/10 , C07F9/65583 , C12N15/113 , C12N2310/14
摘要： The present disclosure relates generally to modulators of human glycolate oxidase enzyme and methods of use and manufacture thereof.
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