公开(公告)号：US20110076396A1

公开(公告)日：2011-03-31

申请号：US12585899

申请日：2009-09-28

申请人： Limin Guan ,  John E. Davies

发明人： Limin Guan ,  John E. Davies

IPC分类号： B05D7/22

CPC分类号： C23C26/00 ,  A61L27/32 ,  A61L27/46 ,  A61L27/56 ,  Y10T428/24997

摘要： The present invention relates to a method of coating a porous material such as a medical implant with a layer of calcium phosphate, wherein the material is submersed in an aqueous solution of calcium, phosphate and carbonate ions, and the pH of the solution is gradually increased. A calcium phosphate coating is formed on an internal surface of the porous material by agitating the solution during coating formation.

摘要翻译： 本发明涉及一种用磷酸钙层涂敷诸如医用植入物的多孔材料的方法，其中所述材料浸入钙，磷酸盐和碳酸根离子的水溶液中，并且溶液的pH逐渐增加 。 通过在涂层形成期间搅拌溶液，在多孔材料的内表面上形成磷酸钙涂层。

公开(公告)号：US20120270031A1

公开(公告)日：2012-10-25

申请号：US13498844

申请日：2010-09-28

申请人： Limin Guan ,  John E. Davies

发明人： Limin Guan ,  John E. Davies

IPC分类号： B05D7/22 ,  B32B3/26 ,  C08L67/04 ,  B32B37/24

CPC分类号： C23C26/00 ,  A61L27/32 ,  A61L27/46 ,  A61L27/56 ,  Y10T428/24997

摘要： The present invention relates to a method of coating a porous material such as a medical implant with a layer of calcium phosphate, wherein the material is submersed in an aqueous solution of calcium, phosphate and carbonate ions, and the pH of the solution is gradually increased. A calcium phosphate coating is formed on an internal surface of the porous material by agitating the solution during coating formation.

摘要翻译： 本发明涉及一种用磷酸钙层涂敷诸如医用植入物的多孔材料的方法，其中所述材料浸入钙，磷酸盐和碳酸根离子的水溶液中，并且溶液的pH逐渐增加 。 通过在涂层形成期间搅拌溶液，在多孔材料的内表面上形成磷酸钙涂层。

公开(公告)号：US07022522B2

公开(公告)日：2006-04-04

申请号：US10134652

申请日：2002-04-30

申请人： Limin Guan ,  Chantal E. Holy ,  Molly S. Shoichet ,  John E. Davies

发明人： Limin Guan ,  Chantal E. Holy ,  Molly S. Shoichet ,  John E. Davies

IPC分类号： C12N5/06 ,  C12N5/08 ,  C12N11/08 ,  A61F2/00

CPC分类号： C12N5/0654 ,  A61L27/18 ,  A61L27/46 ,  A61L27/56 ,  C12N5/0068 ,  C12N2533/18 ,  C12N2533/40 ,  C08L67/04

摘要： A polymer scaffold is provided comprising an extensively interconnected macroporous network. The polymer scaffold embodies macropores having a diameter in a range of 0.5-3.5 mm, and preferably in a range of about 1.0-2.0 mm. The polymer scaffold is prepared using a novel process which advantageously combines the techniques of particulate leaching and phase inversion to render a process that provides amplified means by which to control the morphology of the resulting polymer scaffold. The polymer scaffold has utility in the area of tissue engineering, particularly as a scaffold for both in vitro and in vivo cell growth. The polymer scaffold may be produced using pure polymer or alternatively a composite material may be formed consisting of a macroporous polymer scaffold and osteoclast-resorbable calcium phosphate particles with a binding agent binding the calcium phosphate particles to the polymer scaffold.

摘要翻译： 提供了一种聚合物支架，其包括广泛互连的大孔网络。 聚合物支架体现了直径在0.5-3.5mm范围内，优选在约1.0-2.0mm范围内的大孔。 聚合物支架使用新颖的方法制备，其有利地结合了颗粒浸出和相转化的技术，以提供提供扩增的方法来控制所得聚合物支架的形态的方法。 聚合物支架在组织工程领域具有实用性，特别是作为体外和体内细胞生长的支架。 聚合物支架可以使用纯聚合物制备，或者可以由复合材料形成，其由大孔聚合物支架和破骨细胞可吸收的磷酸钙颗粒与具有将磷酸钙颗粒结合到聚合物支架的结合剂组成。