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    IMMUNE PRIVILEGED AND MODULATORY PROGENITOR CELLS
    1.
    发明申请
    IMMUNE PRIVILEGED AND MODULATORY PROGENITOR CELLS 有权
    免疫特异性和调节性PROGENITOR细胞

    公开(公告)号：US20090285842A1

    公开(公告)日：2009-11-19

    申请号：US12299736

    申请日：2007-05-04

    Applicant: John E. Davies ,  Jane Ennis ,  Alejandro Gomez-Aristiz-Abal ,  Dolores Baksh

    Inventor： John E. Davies ,  Jane Ennis ,  Alejandro Gomez-Aristiz-Abal ,  Dolores Baksh

    IPC: A61K39/00

    CPC classification number: A61K35/51 ,  A61K35/12 ,  A61K35/44 ,  C12N5/0665

    Abstract: Described herein is a method for modulating an immune reaction between lymphocytes and a body recognized by the lymphocytes as foreign. The method exploits the immunomodulating activity of a new class of progenitor cells termed HUCPVCs derived from the perivascular region of human umbilical cord. The method can also employ soluble factors exuded by cultured HUCPVCs. The method is useful to treat immune disorders including graft versus host disease, autoimmune disorders, and the like.

    Abstract translation: 本文描述了一种调节淋巴细胞与被淋巴细胞识别的身体之间的免疫反应的方法。 该方法利用了源自人脐带血管周围区域的称为HUCPVCs的新一类祖细胞的免疫调节活性。 该方法还可以使用培养的HUCPVCs渗出的可溶性因子。 该方法可用于治疗免疫疾病，包括移植物抗宿主病，自身免疫性疾病等。

    Method for forming a liquid phase epitaxial film on a wafer
    2.
    发明授权
    Method for forming a liquid phase epitaxial film on a wafer 失效
    在晶片上形成液相外延膜的方法

    公开(公告)号：US4190683A

    公开(公告)日：1980-02-26

    申请号：US937243

    申请日：1978-08-28

    Applicant: John E. Davies ,  Guido Galli

    Inventor： John E. Davies ,  Guido Galli

    IPC: C30B19/06 ,  C30B19/10 ,  H01F41/28 ,  H01L21/208 ,  H01F10/02

    CPC classification number: C30B19/10 ,  C30B19/068 ,  H01F41/28

    Abstract: A method of forming an improved liquid phase epitaxial film on a wafer. The resultant film has improved uniformity of magnetic properties, such as the collapse field (H.sub.o), across the surface of the wafer as well as being substantially free of mesa defects on the surface. The method includes the step of growing the liquid phase epitaxial film while the wafer is in the horizontal plane. The wafer is removed from the melt while the wafer is tilted at an angle from the horizontal plane so that the melt may drain from the wafer. Then the wafer is positioned in a horizontal plane again and rotated to remove the remaining melt droplets from the edge of the wafer. In a preferred embodiment, a plurality of wafers are positioned in a wafer holding means so that the wafers are arranged in a stacked manner having substantially the same space between adjacent wafers. Wafers may also be stacked in pairs that are back-to-back while carrying out this method.

    Abstract translation: 一种在晶片上形成改进的液相外延膜的方法。 所得到的膜具有提高了晶片表面上的磁性能（例如塌陷场（Ho））的均匀性，并且基本上没有表面上的台面缺陷。 该方法包括当晶片处于水平面时生长液相外延膜的步骤。 当晶片与水平面倾斜一定角度时，晶片从熔体中移除，使得熔体可能从晶片排出。 然后再次将晶片定位在水平平面中并旋转以从晶片的边缘去除剩余的熔体液滴。 在优选实施例中，将多个晶片定位在晶片保持装置中，使得晶片以相邻晶片之间具有基本相同空间的堆叠方式布置。 在执行该方法的同时，晶片也可以成对地堆叠成背对背。

    IMMUNE PRIVILEGED AND MODULATORY PROGENITOR CELLS
    5.
    发明申请
    IMMUNE PRIVILEGED AND MODULATORY PROGENITOR CELLS 有权
    免疫特异性和调节性PROGENITOR细胞

    公开(公告)号：US20130089565A1

    公开(公告)日：2013-04-11

    申请号：US13630312

    申请日：2012-09-28

    Applicant: John E. Davies ,  Jane Ennis ,  Alejandro Gomez-Aristiz-Abal ,  Dolores Baksh

    Inventor： John E. Davies ,  Jane Ennis ,  Alejandro Gomez-Aristiz-Abal ,  Dolores Baksh

    IPC: A61K35/12

    CPC classification number: A61K35/51 ,  A61K35/12 ,  A61K35/44 ,  C12N5/0665

    Abstract: Described herein is a method for modulating an immune reaction between lymphocytes and a body recognized by the lymphocytes as foreign. The method exploits the immunomodulating activity of a new class of progenitor cells termed HUCPVCs derived from the perivascular region of human umbilical cord. The method can also emply soluble factors exuded by cultured HUCPVCs. The method is useful to treat immune disorders including graft versus host disease, autoimmune disorders, and the like.

    Abstract translation: 本文描述了一种调节淋巴细胞与被淋巴细胞识别的身体之间的免疫反应的方法。 该方法利用了源自人脐带血管周围区域的称为HUCPVCs的新一类祖细胞的免疫调节活性。 该方法还可以通过培养HUCPVCs渗出的可溶性因子。 该方法可用于治疗免疫疾病，包括移植物抗宿主病，自身免疫性疾病等。

    Macroporous polymer scaffold containing calcium phosphate particles
    8.
    发明授权
    Macroporous polymer scaffold containing calcium phosphate particles 失效
    含磷酸钙颗粒的大孔聚合物支架

    公开(公告)号：US07022522B2

    公开(公告)日：2006-04-04

    申请号：US10134652

    申请日：2002-04-30

    Applicant: Limin Guan ,  Chantal E. Holy ,  Molly S. Shoichet ,  John E. Davies

    Inventor： Limin Guan ,  Chantal E. Holy ,  Molly S. Shoichet ,  John E. Davies

    IPC: C12N5/06 ,  C12N5/08 ,  C12N11/08 ,  A61F2/00

    CPC classification number: C12N5/0654 ,  A61L27/18 ,  A61L27/46 ,  A61L27/56 ,  C12N5/0068 ,  C12N2533/18 ,  C12N2533/40 ,  C08L67/04

    Abstract: A polymer scaffold is provided comprising an extensively interconnected macroporous network. The polymer scaffold embodies macropores having a diameter in a range of 0.5-3.5 mm, and preferably in a range of about 1.0-2.0 mm. The polymer scaffold is prepared using a novel process which advantageously combines the techniques of particulate leaching and phase inversion to render a process that provides amplified means by which to control the morphology of the resulting polymer scaffold. The polymer scaffold has utility in the area of tissue engineering, particularly as a scaffold for both in vitro and in vivo cell growth. The polymer scaffold may be produced using pure polymer or alternatively a composite material may be formed consisting of a macroporous polymer scaffold and osteoclast-resorbable calcium phosphate particles with a binding agent binding the calcium phosphate particles to the polymer scaffold.

    Abstract translation: 提供了一种聚合物支架，其包括广泛互连的大孔网络。 聚合物支架体现了直径在0.5-3.5mm范围内，优选在约1.0-2.0mm范围内的大孔。 聚合物支架使用新颖的方法制备，其有利地结合了颗粒浸出和相转化的技术，以提供提供扩增的方法来控制所得聚合物支架的形态的方法。 聚合物支架在组织工程领域具有实用性，特别是作为体外和体内细胞生长的支架。 聚合物支架可以使用纯聚合物制备，或者可以由复合材料形成，其由大孔聚合物支架和破骨细胞可吸收的磷酸钙颗粒与具有将磷酸钙颗粒结合到聚合物支架的结合剂组成。

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