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公开(公告)号：US08426191B2
公开(公告)日：2013-04-23
申请号：US12632041
申请日：2009-12-07
申请人： Shengde Zhou , Lonnie O'Neal Ingram , Keelnatham T. Shanmugam , Lorraine Yomano , Tammy B. Grabar , Jonathan C. Moore
发明人： Shengde Zhou , Lonnie O'Neal Ingram , Keelnatham T. Shanmugam , Lorraine Yomano , Tammy B. Grabar , Jonathan C. Moore
摘要： The present invention provides derivatives of Escherichia coli constructed for the production of lactic acid. The transformed E. coli of the invention are prepared by deleting the genes that encode competing pathways followed by a growth-based selection for mutants with improved performance. These transformed E. coli are useful for providing an increased supply of lactic acid for use in food and industrial applications.
摘要翻译： 本发明提供了用于生产乳酸的大肠杆菌的衍生物。 本发明的转化的大肠杆菌通过删除编码竞争性途径的基因，随后是具有改进性能的突变体的基于生长的选择来制备。 这些转化的大肠杆菌可用于提供用于食品和工业应用的增加的乳酸供应。
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公开(公告)号：US07629162B2
公开(公告)日：2009-12-08
申请号：US11501137
申请日：2006-08-08
申请人： Shengde Zhou , Lonnie O'Neal Ingram , Keelnatham T. Shanmugam , Lorraine Yomano , Tammy B. Grabar , Jonathan C. Moore
发明人： Shengde Zhou , Lonnie O'Neal Ingram , Keelnatham T. Shanmugam , Lorraine Yomano , Tammy B. Grabar , Jonathan C. Moore
摘要： The present invention provides derivatives of ethanologenic Escherichia coli K011 constructed for the production of lactic acid. The transformed E. coli of the invention are prepared by deleting the genes that encode competing pathways followed by a growth-based selection for mutants with improved performance. These transformed E. coli are useful for providing an increased supply of lactic acid for use in food and industrial applications.
摘要翻译： 本发明提供了用于生产乳酸的酿酒酵母大肠杆菌K011的衍生物。 本发明的转化的大肠杆菌通过删除编码竞争性途径的基因，随后是具有改进性能的突变体的基于生长的选择来制备。 这些转化的大肠杆菌可用于提供用于食品和工业应用的增加的乳酸供应。
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公开(公告)号：US20070037265A1
公开(公告)日：2007-02-15
申请号：US11501137
申请日：2006-08-08
申请人： Shengde Zhou , Lonnie Ingram , Keelnatham Shanmugam , Lorraine Yomano , Tammy Grabar , Jonathan Moore
发明人： Shengde Zhou , Lonnie Ingram , Keelnatham Shanmugam , Lorraine Yomano , Tammy Grabar , Jonathan Moore
摘要： The present invention provides derivatives of ethanologenic Escherichia coli K011 constructed for the production of lactic acid. The transformed E. coli of the invention are prepared by deleting the genes that encode competing pathways followed by a growth-based selection for mutants with improved performance. These transformed E. coli are useful for providing an increased supply of lactic acid for use in food and industrial applications.
摘要翻译： 本发明提供了用于生产乳酸的酿酒酵母大肠杆菌K011的衍生物。 本发明的转化的大肠杆菌通过删除编码竞争性途径的基因，随后是具有改进性能的突变体的基于生长的选择来制备。 这些转化的大肠杆菌可用于提供用于食品和工业应用的增加的乳酸供应。
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公开(公告)号：US20100203602A1
公开(公告)日：2010-08-12
申请号：US12632041
申请日：2009-12-07
申请人： SHENGDE ZHOU , LONNIE O'NEAL INGRAM , KEELNATHAM T. SHANMUGAM , LORRAINE YOMANO , TAMMY B. GRABAR , JONATHAN C. MOORE
发明人： SHENGDE ZHOU , LONNIE O'NEAL INGRAM , KEELNATHAM T. SHANMUGAM , LORRAINE YOMANO , TAMMY B. GRABAR , JONATHAN C. MOORE
摘要： The present invention provides derivatives of Escherichia coli constructed for the production of lactic acid. The transformed E. coli of the invention are prepared by deleting the genes that encode competing pathways followed by a growth-based selection for mutants with improved performance. These transformed E. coli are useful for providing an increased supply of lactic acid for use in food and industrial applications.
摘要翻译： 本发明提供了用于生产乳酸的大肠杆菌的衍生物。 本发明的转化的大肠杆菌通过删除编码竞争性途径的基因，随后是具有改进性能的突变体的基于生长的选择来制备。 这些转化的大肠杆菌可用于提供用于食品和工业应用的增加的乳酸供应。
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