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公开(公告)号：US20070037265A1
公开(公告)日：2007-02-15
申请号：US11501137
申请日：2006-08-08
申请人： Shengde Zhou , Lonnie Ingram , Keelnatham Shanmugam , Lorraine Yomano , Tammy Grabar , Jonathan Moore
发明人： Shengde Zhou , Lonnie Ingram , Keelnatham Shanmugam , Lorraine Yomano , Tammy Grabar , Jonathan Moore
摘要： The present invention provides derivatives of ethanologenic Escherichia coli K011 constructed for the production of lactic acid. The transformed E. coli of the invention are prepared by deleting the genes that encode competing pathways followed by a growth-based selection for mutants with improved performance. These transformed E. coli are useful for providing an increased supply of lactic acid for use in food and industrial applications.
摘要翻译： 本发明提供了用于生产乳酸的酿酒酵母大肠杆菌K011的衍生物。 本发明的转化的大肠杆菌通过删除编码竞争性途径的基因，随后是具有改进性能的突变体的基于生长的选择来制备。 这些转化的大肠杆菌可用于提供用于食品和工业应用的增加的乳酸供应。
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公开(公告)号：US20100112656A1
公开(公告)日：2010-05-06
申请号：US12375484
申请日：2007-08-08
摘要： The invention provides recombinant bacteria, which comprise a full complement of heterologous ethanol production genes. Expression of the full complement of heterologous ethanol production genes causes the recombinant bacteria to produce ethanol as the primary fermentation product when grown in mineral salts medium, without the addition of complex nutrients. Methods for producing the recombinant bacteria and methods for producing ethanol using the recombinant bacteria are also disclosed.
摘要翻译： 本发明提供重组细菌，其包含全部异源乙醇生产基因。 异源乙醇生产基因的完整补体的表达导致重组细菌在无矿物质培养基中生长时产生乙醇作为主要的发酵产物，而不添加复杂的营养物质。 还公开了使用重组细菌生产重组细菌的方法和生产乙醇的方法。
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3.发明授权Materials and methods for the efficient production of acetate and other products 有权有效生产乙酸酯等产品的材料和方法公开(公告)号：US07977075B2
公开(公告)日：2011-07-12
申请号：US12235074
申请日：2008-09-22
IPC分类号： C12N1/20 , C12N9/00 , C12N9/04 , C12N9/02 , C12N9/10 , C12N9/14 , C12Q1/68 , C07H21/04 , C07H21/02 , C12P7/00
CPC分类号： C12N9/001 , C12N9/0006 , C12N9/0008 , C12N9/1029 , C12N9/14 , C12P7/40 , C12P7/54 , Y02E50/17
摘要： The subject invention provides materials and methods wherein unique and advantageous combinations of gene mutations are used to direct carbon flow from sugars to a single product. The techniques of the subject invention can be used to obtain products from native pathways as well as from recombinant pathways. In preferred embodiments, the subject invention provides new materials and methods for the efficient production of acetate and pyruvic acid.
摘要翻译： 本发明提供的材料和方法，其中使用基因突变的独特且有利的组合来引导碳从碳流到单一产物。 本发明的技术可以用于从天然途径以及重组途径获得产物。 在优选的实施方案中，本发明提供了用于有效制备乙酸酯和丙酮酸的新材料和方法。
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公开(公告)号：US08716002B2
公开(公告)日：2014-05-06
申请号：US12375484
申请日：2007-08-08
摘要： The invention provides recombinant bacteria, which comprise a full complement of heterologous ethanol production genes. Expression of the full complement of heterologous ethanol production genes causes the recombinant bacteria to produce ethanol as the primary fermentation product when grown in mineral salts medium, without the addition of complex nutrients. Methods for producing the recombinant bacteria and methods for producing ethanol using the recombinant bacteria are also disclosed.
摘要翻译： 本发明提供重组细菌，其包含全部异源乙醇生产基因。 异源乙醇生产基因的完整补体的表达导致重组细菌在无矿物质培养基中生长时产生乙醇作为主要的发酵产物，而不添加复杂的营养物质。 还公开了使用重组细菌生产重组细菌的方法和生产乙醇的方法。
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5.发明授权Materials and methods for the efficient production of acetate and other products 有权有效生产乙酸酯等产品的材料和方法公开(公告)号：US08383374B2
公开(公告)日：2013-02-26
申请号：US13154765
申请日：2011-06-07
IPC分类号： C12P7/00 , C12N9/00 , C12N9/02 , C12N9/10 , C12N9/14 , C12N1/20 , C12Q1/68 , C07H21/04 , C07H21/02 , C12N9/04
CPC分类号： C12N9/001 , C12N9/0006 , C12N9/0008 , C12N9/1029 , C12N9/14 , C12P7/40 , C12P7/54 , Y02E50/17
摘要： The subject invention provides materials and methods wherein unique and advantageous combinations of gene mutations are used to direct carbon flow from sugars to a single product. The techniques of the subject invention can be used to obtain products from native pathways as well as from recombinant pathways. In preferred embodiments, the subject invention provides new materials and methods for the efficient production of acetate and pyruvic acid.
摘要翻译： 本发明提供的材料和方法，其中使用基因突变的独特且有利的组合来引导碳从碳流到单一产物。 本发明的技术可以用于从天然途径以及重组途径获得产物。 在优选的实施方案中，本发明提供了用于有效制备乙酸酯和丙酮酸的新材料和方法。
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公开(公告)号：US08426191B2
公开(公告)日：2013-04-23
申请号：US12632041
申请日：2009-12-07
申请人： Shengde Zhou , Lonnie O'Neal Ingram , Keelnatham T. Shanmugam , Lorraine Yomano , Tammy B. Grabar , Jonathan C. Moore
发明人： Shengde Zhou , Lonnie O'Neal Ingram , Keelnatham T. Shanmugam , Lorraine Yomano , Tammy B. Grabar , Jonathan C. Moore
摘要： The present invention provides derivatives of Escherichia coli constructed for the production of lactic acid. The transformed E. coli of the invention are prepared by deleting the genes that encode competing pathways followed by a growth-based selection for mutants with improved performance. These transformed E. coli are useful for providing an increased supply of lactic acid for use in food and industrial applications.
摘要翻译： 本发明提供了用于生产乳酸的大肠杆菌的衍生物。 本发明的转化的大肠杆菌通过删除编码竞争性途径的基因，随后是具有改进性能的突变体的基于生长的选择来制备。 这些转化的大肠杆菌可用于提供用于食品和工业应用的增加的乳酸供应。
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公开(公告)号：US07629162B2
公开(公告)日：2009-12-08
申请号：US11501137
申请日：2006-08-08
申请人： Shengde Zhou , Lonnie O'Neal Ingram , Keelnatham T. Shanmugam , Lorraine Yomano , Tammy B. Grabar , Jonathan C. Moore
发明人： Shengde Zhou , Lonnie O'Neal Ingram , Keelnatham T. Shanmugam , Lorraine Yomano , Tammy B. Grabar , Jonathan C. Moore
摘要： The present invention provides derivatives of ethanologenic Escherichia coli K011 constructed for the production of lactic acid. The transformed E. coli of the invention are prepared by deleting the genes that encode competing pathways followed by a growth-based selection for mutants with improved performance. These transformed E. coli are useful for providing an increased supply of lactic acid for use in food and industrial applications.
摘要翻译： 本发明提供了用于生产乳酸的酿酒酵母大肠杆菌K011的衍生物。 本发明的转化的大肠杆菌通过删除编码竞争性途径的基因，随后是具有改进性能的突变体的基于生长的选择来制备。 这些转化的大肠杆菌可用于提供用于食品和工业应用的增加的乳酸供应。
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公开(公告)号：US20090082600A1
公开(公告)日：2009-03-26
申请号：US12156872
申请日：2008-06-05
申请人： Shengde Zhou
发明人： Shengde Zhou
摘要： A native homoethanol pathway including chromosomal deletions of genes that are competitive with the native homoethanol pathway, and a highly anaerobically expressed pyruvate dehydrogenase operon. Bacteria including the native homoethanol pathway. A method of making a bacteria derivative including a native homoethanol pathway by deleting genes that are competitive with ethanol production pathways, and performing transcriptional gene fusion and highly anaerobically expressing pyruvate dehydrogenase operon. A method of producing ethanol by fermenting bacteria including the native homoethanol pathway with biomass, and producing ethanol. Ethanol produced by the above method.
摘要翻译： 一种天然的均乙醇途径，包括与天然均乙醇途径竞争的基因的染色体缺失，以及高度厌氧表达的丙酮酸脱氢酶操纵子。 细菌包括天然的均乙醇途径。 通过删除与乙醇生产途径竞争的基因，进行转录基因融合和高度厌氧表达丙酮酸脱氢酶操纵子的方法制备包括天然均乙醇途径的细菌衍生物的方法。 通过用生物质发酵包括天然均乙醇途径的细菌并生产乙醇来生产乙醇的方法。 通过上述方法生产的乙醇。
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公开(公告)号：US20060110812A1
公开(公告)日：2006-05-25
申请号：US11246405
申请日：2005-10-07
申请人： Lonnie O'Neal Ingram , Shengde Zhou
发明人： Lonnie O'Neal Ingram , Shengde Zhou
CPC分类号： C12N9/2437 , C12N15/74 , C12P7/10 , C12P19/14 , C12Y302/01004 , Y02E50/16 , Y02E50/17
摘要： The invention provides compositions and methods for the synergistic degradation of oligosaccharides by endoglucanases. The invention further provides recombinant host cells containing one or more genes encoding endoglucanses which are capable of the synergistic degradation of oligosaccharides. Preferred host cells of the invention are ethanologenic and capable of carrying out simultaneous saccharification and fermentation resulting in the production of ethanol from complex cellulose substrates
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10.发明授权公开(公告)号：US07026152B2
公开(公告)日：2006-04-11
申请号：US09885297
申请日：2001-06-19
申请人： Lonnie O'Neal Ingram , Shengde Zhou
发明人： Lonnie O'Neal Ingram , Shengde Zhou
CPC分类号： C12N9/2437 , C12N15/74 , C12P7/10 , C12P19/14 , C12Y302/01004 , Y02E50/16 , Y02E50/17
摘要： The invention provides compositions and methods for the synergistic degradation of oligosaccharides by endoglucanases. The invention further provides recombinant host cells containing one or more genes encoding endoglucanses which are capable of the synergistic degradation of oligosaccharides. Preferred host cells of the invention are ethanologenic and capable of carrying out simultaneous saccharification and fermentation resulting in the production of ethanol from complex cellulose substrates.
摘要翻译： 本发明提供了通过内切葡聚糖酶协同降解寡糖的组合物和方法。 本发明还提供含有一种或多种编码能够协同降解寡糖的内切葡聚糖的基因的重组宿主细胞。 本发明优选的宿主细胞具有酿酒酵母并能够同时进行糖化和发酵，从而从复合纤维素底物生产乙醇。
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