公开(公告)号：US20170056491A1

公开(公告)日：2017-03-02

申请号：US15307926

申请日：2015-03-26

Applicant: National Health Research Institutes ,  Lu-hai Wang

Inventor： Yen-Hung Chow ,  Yueh-Liang Tsou ,  Pele Choi-Sing Chong

IPC: A61K39/125

CPC classification number: A61K39/125 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/542 ,  A61K2039/545 ,  A61K2039/55566 ,  A61K2039/57 ,  C12N2710/10323 ,  C12N2710/10343 ,  C12N2770/32323 ,  C12N2770/32334 ,  C12N2770/32351 ,  C12N2770/32371 ,  Y02A50/466

Abstract: The present invention relates to a recombinant adenoviral vector for generating immunity against enterovirus infection. In one embodiment, the recombinant adenoviral vector of the invention comprises an expression cassette encoding a PI protein and a 3 CD protease of an enterovirus. In another embodiment, the recombinant adenoviral vector of the invention comprises an expression cassette encoding a 3C protease or a 3CD protease of an enterovirus. The present invention also relates to a vaccine composition comprising the recombinant adenoviral vector as described. A method of inducing an immune response in a subject against enterovirus infection using the recombinant adenoviral vector and the vaccine composition is provided. Further provided is a method for producing virus like particles of an enterovirus by expressing the adenoviral vector as described herein in mammalian cells.

Abstract translation: 本发明涉及用于产生针对肠道病毒感染的免疫的重组腺病毒载体。 在一个实施方案中，本发明的重组腺病毒载体包含编码肠道病毒的PI蛋白和3CD蛋白酶的表达盒。 在另一个实施方案中，本发明的重组腺病毒载体包含编码肠病毒的3C蛋白酶或3CD蛋白酶的表达盒。 本发明还涉及包含如上所述的重组腺病毒载体的疫苗组合物。 提供了使用重组腺病毒载体和疫苗组合物诱导受试者免疫应答的方法。 还提供了通过在哺乳动物细胞中表达本文所述的腺病毒载体来产生病毒样肠道病毒颗粒的方法。

公开(公告)号：US20170247660A1

公开(公告)日：2017-08-31

申请号：US15512489

申请日：2015-09-16

Applicant: Lu-Hai WANG ,  National Health Research Institutes

Inventor： Lin-Ju YEN ,  Ko-Jiunn LIU ,  Men-Luh YEN

IPC: C12N5/071 ,  A61K35/48 ,  C12N5/0775

CPC classification number: C12N5/0682 ,  A61K35/48 ,  C12N5/0668 ,  C12N2509/00

Abstract: The present application provides progenitor cells and a preparing method thereof. The preparing method comprises obtaining a tissue sample containing myometrium from uterus, treating the tissue sample with collagenase, and culturing the treated tissue sample to obtain the progenitor cells, wherein the progenitor cell is multipotent and immunomodulatory. The present application also provides a method for treating a degenerative disease, an ischemic disease or a disease caused by abnormal immune response comprising administering the progenitor cells to a patient subjecting the disease.