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20 条记录 (耗时 0.066 秒)

    23-O-substituted 5-O-mycaminosyltylonide derivatives
    9.
    发明申请
    23-O-substituted 5-O-mycaminosyltylonide derivatives 审中-公开
    23-O-取代的5-O-碳霉糖基海藻衍生物

    公开(公告)号：US20050020823A1

    公开(公告)日：2005-01-27

    申请号：US10840948

    申请日：2004-05-07

    申请人： Ly Phan ,  Yao-Ling Qiu ,  Yat Or ,  Nha Vo ,  Tianying Jian ,  Ying Hou ,  Marina BusuyeK

    发明人： Ly Phan ,  Yao-Ling Qiu ,  Yat Or ,  Nha Vo ,  Tianying Jian ,  Ying Hou ,  Marina BusuyeK

    IPC分类号： A61P31/04 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： There are described novel 5-O-mycaminosyltylonide (OMT) analogs possessing increased antibacterial activity toward Gram positive and Gram negative bacteria as well as macrolide resistant Gram positives and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described are a method for treating bacterial infections by administering to a patient a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds

    摘要翻译： 描述了具有对革兰氏阳性和革兰氏阴性细菌以及大环内酯抗性革兰氏阳性和药学上可接受的组合物具有增加的抗细菌活性的新型5-O-碳霉糖基托伦（OMT）类似物，其包含治疗有效量的本发明化合物与 药学上可接受的载体。 还描述了通过向患者施用含有治疗有效量的本发明化合物的药物组合物和用于制备这些化合物的方法来治疗细菌感染的方法

    6-11 Bicyclic erythromycin derivatives
    10.
    发明申请
    6-11 Bicyclic erythromycin derivatives 失效
    6-11双环红霉素衍生物

    公开(公告)号：US20050187169A1

    公开(公告)日：2005-08-25

    申请号：US11029640

    申请日：2005-01-05

    申请人： Nha Vo ,  Guoqiang Wang ,  Guoyou Xu ,  Ying Hou ,  Ying Sun ,  Ly Phan ,  Zhe Wang ,  Yat Or

    发明人： Nha Vo ,  Guoqiang Wang ,  Guoyou Xu ,  Ying Hou ,  Ying Sun ,  Ly Phan ,  Zhe Wang ,  Yat Or

    IPC分类号： A61K31/70 ,  A61K31/7048 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formulaes I, II, III, or IV, or a racemate, enantiomer, regioisomer, salt, ester or prodrug thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I，II，III或IV的化合物或其外消旋体，对映异构体，区域异构体，盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。