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    High performance pooled hot spares
    5.
    发明授权
    High performance pooled hot spares 有权
    高性能集合热备件

    公开(公告)号：US08086893B1

    公开(公告)日：2011-12-27

    申请号：US12534017

    申请日：2009-07-31

    Applicant: Jeffrey S. MacFarland ,  R. Christopher Fore

    Inventor： Jeffrey S. MacFarland ,  R. Christopher Fore

    IPC: G06F11/00

    CPC classification number: G06F11/1088

    Abstract: A high-performance spare disk pool is created as a logical construct for provisioning and managing striped hot spares. Two or more drives (nonvolatile mass storage devices) are logically grouped together to allow the input/output (I/O) write bandwidth during RAID reconstruction to be increased over that of a single drive. The reconstructed data can be written to the spare disk pool in a striped manner. After the reconstruction is complete, a background process can be executed to copy the reconstructed data on the spare disk pool back to a single physical spare disk drive with minimal performance impact.

    Abstract translation: 创建高性能备用磁盘池作为配置和管理条带化热备件的逻辑结构。 两个或多个驱动器（非易失性大容量存储设备）在逻辑上分组在一起，以允许RAID重建期间的输入/输出（I / O）写入带宽增加到单个驱动器的输入/输出（I / O）写入带宽。 重建的数据可以以条带方式写入备用磁盘池。 重建完成后，可以执行后台进程，将备用磁盘池上的重建数据复制回单个物理备用磁盘驱动器，而性能影响最小。

    System and method utilizing guided fluorescence for high intensity applications
    6.
    发明授权
    System and method utilizing guided fluorescence for high intensity applications 有权
    利用引导荧光进行高强度应用的系统和方法

    公开(公告)号：US07998181B2

    公开(公告)日：2011-08-16

    申请号：US11504399

    申请日：2006-08-15

    Applicant: John L. Nightingale ,  Gregory J. Spooner ,  David A. Gollnick ,  Dean A. MacFarland

    Inventor： John L. Nightingale ,  Gregory J. Spooner ,  David A. Gollnick ,  Dean A. MacFarland

    IPC: A61B18/18

    CPC classification number: G02B6/4298 ,  A61B18/203 ,  A61B2018/00452

    Abstract: A fluorescence concentrator system that provides for high brightness light source. The system can include a host doped with fluorescent material, which is optically pumped by an adjacent illumination source. The fluorescence concentrator captures a portion of the isotropically emitted fluorescent light and guides it to an output surface. The fluorescent energy emerging the output surface provides a high brightness light source suitable for a number of applications. For example, the fluorescence concentrator system can be used as the light source in a medical apparatus suitable for various aesthetic procedures. Further aspects of the fluorescent concentrator system can include providing for controlling the illumination source to output pumping energy suitable for high energy applications.

    Abstract translation: 提供高亮度光源的荧光聚光器系统。 该系统可以包括掺杂有荧光材料的主体，其被相邻的照明源光泵浦。 荧光浓缩器捕获一部分各向同性地发射的荧光并将其引导到输出表面。 出现输出表面的荧光能量提供了适合多种应用的高亮度光源。 例如，荧光浓缩器系统可以用作适于各种美学方法的医疗装置中的光源。 荧光浓缩器系统的其它方面可以包括提供控制照明源以输出适合于高能量应用的泵送能量。

    Systems and methods for automatic provisioning of storage and operating system installation from pre-existing iSCSI target
    7.
    发明授权
    Systems and methods for automatic provisioning of storage and operating system installation from pre-existing iSCSI target 有权
    从预先存在的iSCSI目标自动配置存储和操作系统安装的系统和方法

    公开(公告)号：US07913075B2

    公开(公告)日：2011-03-22

    申请号：US12167250

    申请日：2008-07-03

    Applicant: Dean Kalman ,  Jeffrey MacFarland

    Inventor： Dean Kalman ,  Jeffrey MacFarland

    IPC: G06F9/24

    CPC classification number: G06F9/4405

    Abstract: A method for provisioning a blade server is provided. The method includes creating a server boot image for a blade server, where the boot image includes an operating system image created from a donor server. Then, the method includes inserting the blade server into a chassis of an enclosure that is capable of receiving multiple blade servers. Then, staring the blade server from a pre-boot execution environment (PXE). The PXE loading an image that prompts a user to install a new operating system from a pre-existing target computer of the enclosure. The method then installs the new operating system. The installing includes creation of a new iSCSI target for the inserted blade server, and partitioning of the iSCSI target. The also includes restarting the inserted blade server. The restarting is configured to boot using the iSCSI target of the inserted blade server, so that the inserted blade server becomes a provisioned blade server. The provisioning is accomplished without a hardware iSCSI initiator for an iSCSI boot.

    Abstract translation: 提供了一种供应刀片服务器的方法。 该方法包括为刀片服务器创建服务器引导映像，其中引导映像包括从供体服务器创建的操作系统映像。 然后，该方法包括将刀片服务器插入到能够接收多个刀片服务器的机箱的机箱中。 然后，将刀片服务器从预引导执行环境（PXE）中盯着。 PXE加载图像，提示用户从机箱的预先存在的目标计算机安装新的操作系统。 该方法然后安装新的操作系统。 安装包括为插入的刀片服务器创建新的iSCSI目标，以及对iSCSI目标进行分区。 还包括重新启动插入的刀片服务器。 重新启动配置为使用插入的刀片服务器的iSCSI目标进行引导，以便插入的刀片服务器成为已配置的刀片服务器。 无需iSCSI引导的硬件iSCSI启动器即可完成配置。

    Methods to mobilize progenitor/stem cells
    8.
    发明授权
    Methods to mobilize progenitor/stem cells 有权
    调动祖细胞/干细胞的方法

    公开(公告)号：US07897590B2

    公开(公告)日：2011-03-01

    申请号：US11841837

    申请日：2007-08-20

    Applicant: Gary J. Bridger ,  Michael J. Abrams ,  Geoffrey W. Henson ,  Ronald Trevor MacFarland ,  Gary B. Calandra ,  Hal E. Broxmeyer ,  David C. Dale

    Inventor： Gary J. Bridger ,  Michael J. Abrams ,  Geoffrey W. Henson ,  Ronald Trevor MacFarland ,  Gary B. Calandra ,  Hal E. Broxmeyer ,  David C. Dale

    IPC: A61K31/33 ,  C07D245/00 ,  C07D487/00

    CPC classification number: A61K31/395 ,  A61K31/33 ,  A61K31/4427 ,  A61K31/496 ,  A61K31/55 ,  A61K31/551 ,  A61K31/555 ,  A61K35/28 ,  A61K38/193 ,  A61K38/195 ,  A61K2035/124 ,  C12N5/0647 ,  A61K2300/00

    Abstract: Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formula Z-linker-Z′  (1) or pharmaceutically acceptable salt thereof wherein Z is a cyclic polyamine containing 9-32 ring members of which 3-8 are nitrogen atoms, said nitrogen atoms separated from each other by at least 2 carbon atoms, and wherein said heterocycle may optionally contain additional heteroatoms besides nitrogen and/or may be fused to an additional ring system; or Z is of the formula wherein A comprises a monocyclic or bicyclic fused ring system containing at least one N and B is H or an organic moiety of 1-20 atoms, Z′ may be embodied in a form as defined by Z above, or alternatively may be of the formula —N(R)—(CR2)n—X wherein each R is independently H or straight, branched or cyclic alkyl (1-6C), n is 1 or 2, and X is an aromatic ring, including heteroaromatic rings, or is a mercaptan; “linker” represents a bond, alkylene (1-6C) or may comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or may contain keto groups or nitrogen or sulfur atoms.

    Abstract translation: 公开了使用结合趋化因子受体CXCR4的化合物来提高动物受试者祖细胞和干细胞计数的方法。 这种化合物的优选实施方案是式Z-接头-Z'（1）或其药学上可接受的盐，其中Z是含有9-32个环成员的环状多胺，其中3-8个是氮原子，所述氮原子从每个 另外通过至少2个碳原子，并且其中所述杂环可以任选地含有除氮之外的另外的杂原子和/或可以与另外的环系稠合; 或Z具有下式：其中A包含含有至少一个N的单环或双环稠合环体系，B是H或1-20个原子的有机部分，Z'可以以上述Z所定义的形式实施，或 或者可以是式-N（R） - （CR 2）n -X，其中每个R独立地为H或直链，支链或环状烷基（1-6C），n为1或2，X为芳环， 包括杂芳环，或是硫醇; “接头”表示键，亚烷基（1-6C）或可包含亚烷基链中所含的芳基，稠合芳基，氧原子，或可含有酮基或氮或硫原子。

    METHODS TO MOBILIZE PROGENITOR/STEM CELLS
    9.
    发明申请
    METHODS TO MOBILIZE PROGENITOR/STEM CELLS 有权
    移动原核细胞/干细胞的方法

    公开(公告)号：US20080063624A1

    公开(公告)日：2008-03-13

    申请号：US11841837

    申请日：2007-08-20

    Applicant: Gary Bridger ,  Michael Abrams ,  Geoffrey Henson ,  Ronald Macfarland ,  Gary Calandra ,  Hal Broxmeyer ,  David Dale

    Inventor： Gary Bridger ,  Michael Abrams ,  Geoffrey Henson ,  Ronald Macfarland ,  Gary Calandra ,  Hal Broxmeyer ,  David Dale

    IPC: A61K31/395 ,  A61K31/4427 ,  A61K38/19 ,  A61P9/00

    CPC classification number: A61K31/395 ,  A61K31/33 ,  A61K31/4427 ,  A61K31/496 ,  A61K31/55 ,  A61K31/551 ,  A61K31/555 ,  A61K35/28 ,  A61K38/193 ,  A61K38/195 ,  A61K2035/124 ,  C12N5/0647 ,  A61K2300/00

    Abstract: Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formula Z-linker-Z′  (1) or pharmaceutically acceptable salt thereof wherein Z is a cyclic polyamine containing 9-32 ring members of which 3-8 are nitrogen atoms, said nitrogen atoms separated from each other by at least 2 carbon atoms, and wherein said heterocycle may optionally contain additional heteroatoms besides nitrogen and/or may be fused to an additional ring system; wherein A comprises a monocyclic or bicyclic fused ring system containing at least one N and B is H or an organic moiety of 1-20 atoms, Z′ may be embodied in a form as defined by Z above, or alternatively may be of the formula —N(R)—(CR2)n—X wherein each R is independently H or straight, branched or cyclic alkyl (1-6C), n is 1 or 2, and X is an aromatic ring, including heteroaromatic rings, or is a mercaptan; “linker” represents a bond, alkylene (1-6C) or may comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or may contain keto groups or nitrogen or sulfur atoms.

    Abstract translation: 公开了使用结合趋化因子受体CXCR4的化合物来提高动物受试者祖细胞和干细胞计数的方法。 这些化合物的优选实施方案具有式<？in-line-formula description =“In-line Formulas”end =“lead”？> Z-linker-Z'（1）<？in-line-formula description =“ 其中Z是含有9-32个环成员的环状多胺，其中3-8个是氮原子，所述氮原子彼此分开至少2个碳原子 并且其中所述杂环可以任选地含有除氮之外的另外的杂原子和/或可以与另外的环系稠合; 其中A包含含有至少一个N的单环或双环稠环体系，B是H或1-20个原子的有机部分，Z'可以以上述Z所定义的形式实施，或者可以是式 <？in-line-formula description =“In-line Formulas”end =“lead”？> - N（R） - （CR 2）N < 其中每个R独立地为H或直链，支链或环状烷基（1-6C），n为1或2，X为 芳环，包括杂芳环，或是硫醇; “接头”表示键，亚烷基（1-6C）或可包含亚烷基链中所含的芳基，稠合芳基，氧原子，或可含有酮基或氮或硫原子。

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