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    SERIAL SYNCHROTRON CRYSTALLOGRAPHY SAMPLE HOLDING SYSTEM
    3.
    发明申请
    SERIAL SYNCHROTRON CRYSTALLOGRAPHY SAMPLE HOLDING SYSTEM 有权

    公开(公告)号：US20220146441A1

    公开(公告)日：2022-05-12

    申请号：US17435801

    申请日：2020-03-06

    申请人： MITEGEN, LLC

    发明人： Robert E. Thorne ,  David Closs ,  Benjamin Apker

    IPC分类号： G01N23/20033

    摘要： A fixed target sample holder for serial synchrotron crystallography comprising a goniometer compatible base, a carrier, a sample holding insert which can be placed into the carrier. The sample holding insert comprising fiducials and windows, wherein each of the windows are respectively configured to accept a sample. The windows can also have holes and texture within each window. Additionally, a sample loading workstation for loading crystals into the sample holder and the removal of excess liquid from the sample, comprising a humidity-controlled chamber, a sample support within the chamber, a capture to place the goniometer-compatible base, and a channel in communication with the chamber that allows for the flow of humidified air into the chamber.

    MICROPLATES AND METHODS FOR PROTEIN CRYSTALLIZATION AND BIOTECHNOLOGY
    4.
    发明申请
    MICROPLATES AND METHODS FOR PROTEIN CRYSTALLIZATION AND BIOTECHNOLOGY 有权
    蛋白质结晶和生物技术的微阵列和方法

    公开(公告)号：US20150093306A1

    公开(公告)日：2015-04-02

    申请号：US14385573

    申请日：2013-03-28

    申请人： MITEGEN, LLC

    发明人： Robert E. Thorne ,  Benjamin Apker ,  Robert Newman

    IPC分类号： B01L3/00 ,  C30B35/00

    CPC分类号： B01L3/5085 ,  B01L2200/0678 ,  B01L2300/0829 ,  B01L2300/0858 ,  B01L2300/0893 ,  C12M23/12 ,  C30B35/002

    摘要： Devices and methods for manual and high-throughput protein crystal growth and growth of other biological and organic crystals. A microplate includes a plurality of cells and a frame that defines the cells in the microplate. In each cell there is at least one well open at top. Each well in a cell may be enclosed at bottom, or it may be open at bottom, in which case the well bottom may be sealed by a separate part, which may be, e.g., a separate film or plate (e.g., of plastic, glass or metal) or a molded part.

    摘要翻译： 手工和高通量蛋白晶体生长和其他生物和有机晶体生长的装置和方法。 微孔板包括多个细胞和限定微孔板中的细胞的框架。 在每个单元格中，至少有一个在顶部打开。 电池中的每个孔可以封闭在底部，或者它可以在底部开放，在这种情况下，井底可以由单独的部分密封，单独的部分可以是例如单独的膜或板（例如，塑料， 玻璃或金属）或模制件。

    SYSTEM FOR RAPID COOLING AND WARMING OF CELLS AND OTHER BIOLOGICAL MATERIAL
    5.
    发明公开
    SYSTEM FOR RAPID COOLING AND WARMING OF CELLS AND OTHER BIOLOGICAL MATERIAL 审中-公开

    公开(公告)号：US20230255194A1

    公开(公告)日：2023-08-17

    申请号：US18303258

    申请日：2023-04-19

    申请人： MiTeGen, LLC

    发明人： Robert E Thorne ,  David Closs ,  Richard Jayne ,  Benjamin Apker

    IPC分类号： A01N1/02 ,  G01N1/42

    CPC分类号： A01N1/0242 ,  G01N1/42

    摘要： A system for cryocooling biological samples includes a first chamber that holds a first amount a cryogenic liquid. A container holder, which is positioned in thermal contact with the first chamber, holds a removable container positioned therein. The container holds a second amount of the cryogenic liquid and forms a second chamber. An elongated tube holder holds a hollow elongated tube into the container. A sample wand holds and transfers a sample holder with a biological sample into the elongated tube while the elongated tube is in the container with the second amount of the cryogenic liquid.

    System for sample storage and shipping for cryoelectron microscopy
    6.
    发明授权
    System for sample storage and shipping for cryoelectron microscopy 有权

    公开(公告)号：US11605524B2

    公开(公告)日：2023-03-14

    申请号：US17034665

    申请日：2020-09-28

    申请人： Mitegen, LLC

    发明人： David Closs ,  Jessica Benitez ,  Benjamin Apker ,  Mazdak Radjainia

    IPC分类号： H01J37/20 ,  G01N1/42

    摘要： A system for storing and shipping samples for cryo-electron microscopy. The system comprising a cassette puck and support platform that accepts commercial cryo-EM sample cassettes and is compatible to a substantial extent with tools used in cryocrystallography. The system can also work with existing Cryo-EM storage and transport puck and cane systems. The cassette puck comprising a receptacle for holding one or more cassettes and a plurality of holes and grooves. The holes and grooves being configured for use with other tools such as tongs, support platforms, and canes.

    System for Rapid Cooling and Warming of Cells and Other Biological Material
    8.
    发明申请
    System for Rapid Cooling and Warming of Cells and Other Biological Material 有权

    公开(公告)号：US20210195889A1

    公开(公告)日：2021-07-01

    申请号：US17056796

    申请日：2019-05-22

    申请人： Mitegen, LLC

    发明人： Robert Thorne ,  David Closs ,  Richard Jayne ,  Benjamin Apker

    IPC分类号： A01N1/02 ,  G01N1/42

    摘要： A system for cryocooling biological samples, including a first chamber configured to hold a first amount a cryogenic liquid; a container holder positioned in thermal contact with the first chamber and configured to hold at least one removable container positioned therein, wherein the container is configured to hold a second amount of the cryogenic liquid and forms a second chamber; an elongated tube holder configured to hold at least one hollow elongated tube into the container; and a sample wand configured to hold and transfer at least one sample holder with a biological sample into the elongated tube while the elongated tube is in the container with the second amount of the cryogenic liquid therein.