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公开(公告)号：US11867558B2
公开(公告)日：2024-01-09
申请号：US16485686
申请日：2018-02-13
申请人： MKS TECHNOLOGY, INC.
CPC分类号： G01J3/0208 , G01J3/0289 , G01J3/44 , G02B7/1822 , G02B7/1827 , G01J3/0218
摘要： Optical systems have uses, such as in spectrometers, for directing a beam. A spectrometer, for example, utilizes an optical system for directing an incident beam toward a sample and receiving a spectroscopy signal from the sample. In various implementations, for example, an optical system may be further configured to move a beam with respect to a target, such as a sample, and still provide a home position where the beam is directed in a stationary configuration. A self-homing (e.g., self-centering) optical system may provide a “home” position in which the beam is directed in a first stationary mode while still allowing a focused beam to be moved with respect to a target in a second dynamic mode.
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公开(公告)号：US10458917B2
公开(公告)日：2019-10-29
申请号：US15864340
申请日：2018-01-08
申请人： MKS Technology, Inc.
IPC分类号： G01N21/65
摘要： A method of measuring Raman scattering includes exciting Raman scattering of a sample with a first wavelength and a second wavelength of electromagnetic radiation traveling along a common optical path to form a first scattered radiation and a second scattered radiation. The first wavelength reaches the sample polarized in a first direction, and the second wavelength reaches the sample polarized in a second direction perpendicular to the first direction. The method includes collecting a first Raman spectrum from the first scattered radiation, collecting a second Raman spectrum from the second scattered radiation, and forming a decomposed Raman spectrum based on the first Raman spectrum and the second Raman spectrum. The decomposed Raman spectrum may be substantially free of noise, such as fluorescence and background radiation. Related spectrometers and laser devices are disclosed.
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公开(公告)号：US20180195965A1
公开(公告)日：2018-07-12
申请号：US15864340
申请日：2018-01-08
申请人： MKS Technology, Inc.
IPC分类号： G01N21/65
CPC分类号： G01N21/65 , G01N2201/06113 , G01N2201/0683
摘要： A method of measuring Raman scattering includes exciting Raman scattering of a sample with a first wavelength and a second wavelength of electromagnetic radiation traveling along a common optical path to form a first scattered radiation and a second scattered radiation. The first wavelength reaches the sample polarized in a first direction, and the second wavelength reaches the sample polarized in a second direction perpendicular to the first direction. The method includes collecting a first Raman spectrum from the first scattered radiation, collecting a second Raman spectrum from the second scattered radiation, and forming a decomposed Raman spectrum based on the first Raman spectrum and the second Raman spectrum. The decomposed Raman spectrum may be substantially free of noise, such as fluorescence and background radiation. Related spectrometers and laser devices are disclosed.
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公开(公告)号：US20210231499A1
公开(公告)日：2021-07-29
申请号：US17054157
申请日：2020-03-25
发明人： Quaid Vohra , Celestin Zemtsop , Mark Watson
摘要： A multi-dispersive spectrometer is provided in which the spectrometer comprises an an optical system configured to direct an excitation signal from an excitation light source toward a sample, receive a spectroscopy signal from the sample, and direct the spectroscopy signal toward the detector. The optical system comprises a movable optical component adapted to move the spectroscopy signal relative to at least one sensor of the detector and the detector is adapted to detect a plurality of discrete shifted spectroscopy signals. A method of obtaining a Raman spectrum from a sample is also provided. The method comprises directing an excitation signal from an excitation light source toward a sample; receiving a spectroscopy signal from the sample; and directing the spectroscopy signal toward a detector, wherein the spectroscopy signal is moved relative to at least one sensor of the detector to provide a plurality of discrete shifted spectroscopy signals.
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公开(公告)号：US20200256724A1
公开(公告)日：2020-08-13
申请号：US16681192
申请日：2019-11-12
发明人： Mark Watson , Shane Buller , Keith Carron
摘要： A spectrometer is provided. In one implementation, for example, a spectrometer comprises an excitation source, a focusing lens, a movable minor, and an actuator assembly. The focusing lens is adapted to focus an incident beam from the excitation source. The actuator assembly is adapted to control the movable minor to move a focused incident beam across a surface of the sample.
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公开(公告)号：US11441948B2
公开(公告)日：2022-09-13
申请号：US17054157
申请日：2020-03-25
申请人： MKS TECHNOLOGY, INC.
发明人： Quaid Vohra , Celestin Zemtsop , Mark Watson
摘要： A multi-dispersive spectrometer is provided in which the spectrometer comprises an optical system configured to direct an excitation signal from an excitation light source toward a sample, receive a spectroscopy signal from the sample, and direct the spectroscopy signal toward the detector. The optical system comprises a movable optical component adapted to move the spectroscopy signal relative to at least one sensor of the detector and the detector is adapted to detect a plurality of discrete shifted spectroscopy signals. A method of obtaining a Raman spectrum from a sample is also provided. The method comprises directing an excitation signal from an excitation light source toward a sample; receiving a spectroscopy signal from the sample; and directing the spectroscopy signal toward a detector, wherein the spectroscopy signal is moved relative to at least one sensor of the detector to provide a plurality of discrete shifted spectroscopy signals.
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公开(公告)号：US20200348179A1
公开(公告)日：2020-11-05
申请号：US16728841
申请日：2019-12-27
发明人： Keith Carron , Shane Buller , Mark Watson
IPC分类号： G01J3/44 , G01N33/536 , G01N21/65 , G01N33/543 , G01J3/06
摘要： A spectroscopic assay is provided. The assay comprises: a motive particle configured to move within a solution, the motive particle comprising a first analyte binding reagent for selectively binding to a target analyte; and a spectroscopic reporter particle configured to provide a predetermined spectroscopic signal in response to being interrogated by a spectrometer, the spectroscopic reporter particle comprising a second analyte binding reagent for selectively binding to the target analyte, wherein the motive particle and the spectroscopic reporter particle are configured to provide a sandwich assay in the presence of the target analyte via the first and second analyte binding reagents.
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公开(公告)号：US20200056938A1
公开(公告)日：2020-02-20
申请号：US16485686
申请日：2018-02-13
摘要： Optical systems have uses, such as in spectrometers, for directing a beam. A spectrometer, for example, utilizes an optical system for directing an incident beam toward a sample and receiving a spectroscopy signal from the sample. In various implementations, for example, an optical system may be further configured to move a beam with respect to a target, such as a sample, and still provide a home position where the beam is directed in a stationary configuration. A self-homing (e.g., self-centering) optical system may provide a “home” position in which the beam is directed in a first stationary mode while still allowing a focused beam to be moved with respect to a target in a second dynamic mode.
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