公开(公告)号：US07189558B2

公开(公告)日：2007-03-13

申请号：US10485782

申请日：2001-09-27

申请人： Ramavana Gururaja ,  Anuj Goel ,  Madhavan Sridharan ,  Ramakrishnan Sadhana Melarkode ,  Madhav Kulkarni ,  Acharya Poornaprajna ,  Deepthy Sathyanathan ,  Sambasivam Ganesh ,  Shrikumar Suryanarayan

发明人： Ramavana Gururaja ,  Anuj Goel ,  Madhavan Sridharan ,  Ramakrishnan Sadhana Melarkode ,  Madhav Kulkarni ,  Acharya Poornaprajna ,  Deepthy Sathyanathan ,  Sambasivam Ganesh ,  Shrikumar Suryanarayan

IPC分类号： C12N1/20

CPC分类号： C12P7/62 ,  Y10S435/886

摘要： In one aspect, the present invention provides an improved method for the manufacture of Pravastatin sodium salt by fermentation under optimal fermentation parameters using a new strain of Streptomyces flavidovirens.

摘要翻译： 在一个方面，本发明提供了一种通过使用新的黄曲霉链霉菌菌株在最佳发酵参数下发酵制备普伐他汀钠盐的改进方法。

公开(公告)号：US08012723B2

公开(公告)日：2011-09-06

申请号：US12686321

申请日：2010-01-12

申请人： Madhav Kulkarni ,  Surekha K. Prabhu ,  Madenahally Channabasappa Shivakumar ,  Prijyajit Sengupta ,  Sanjay Tiwari ,  Rakesh Mendhe ,  Nitin Patil ,  Laxmi Adhikary ,  Anand Khedkar ,  Ramakrishnan Melarkode ,  Ramavana Gururaja ,  Shrikumar Suryanarayan

发明人： Madhav Kulkarni ,  Surekha K. Prabhu ,  Madenahally Channabasappa Shivakumar ,  Prijyajit Sengupta ,  Sanjay Tiwari ,  Rakesh Mendhe ,  Nitin Patil ,  Laxmi Adhikary ,  Anand Khedkar ,  Ramakrishnan Melarkode ,  Ramavana Gururaja ,  Shrikumar Suryanarayan

IPC分类号： C12P17/00 ,  C12P17/16 ,  C12N1/20 ,  C12N15/00

CPC分类号： C12R1/465 ,  C12P17/188

摘要： The present invention discloses a new strain of Streptomyces sp. BICC 7522, its variants or mutants and use of the strain for the production of macrolides, process of production and purification of macrolides.

摘要翻译： 本发明公开了一种新的Streptomyces sp。 BICC 7522，其变体或突变体以及该菌株用于生产大环内酯类，大环内酯类的生产和纯化方法。

公开(公告)号：US07704725B2

公开(公告)日：2010-04-27

申请号：US11578108

申请日：2004-04-12

申请人： Madhav Kulkarni ,  Surekha K. Prabhu ,  Madenahally Channabasappa Shivakumar ,  Prijyajit Sengupta ,  Sanjay Tiwari ,  Rakesh Mendhe ,  Nitin Patil ,  Laxmi Adhikary ,  Anand Khedkar ,  Ramakrishnan Melarkode ,  Ramavana Gururaja ,  Shrikumar Suryanarayan

发明人： Madhav Kulkarni ,  Surekha K. Prabhu ,  Madenahally Channabasappa Shivakumar ,  Prijyajit Sengupta ,  Sanjay Tiwari ,  Rakesh Mendhe ,  Nitin Patil ,  Laxmi Adhikary ,  Anand Khedkar ,  Ramakrishnan Melarkode ,  Ramavana Gururaja ,  Shrikumar Suryanarayan

IPC分类号： C12P17/00 ,  C12P17/16 ,  C12N1/20 ,  C12N15/00

CPC分类号： C12R1/465 ,  C12P17/188

摘要： The present invention discloses a new strain of Streptomyces sp. BICC 7522, its variants or mutants and use of the strain for the production of macrolides, process of production and purification of microlides.

摘要翻译： 本发明公开了一种新的Streptomyces sp。 BICC 7522，其变体或突变体以及该菌株用于生产大环内酯类物质，生产和纯化微藻的过程。

公开(公告)号：US20100184985A1

公开(公告)日：2010-07-22

申请号：US12686321

申请日：2010-01-12

申请人： Madhav Kulkarni ,  Surekha K. Prabhu ,  Madenahally Channabasappa Shivakumar ,  Prijyajit Sengupta ,  Sanjay Tiwari ,  Rakesh Mendhe ,  Nitin Patil ,  Laxmi Adhikary ,  Anand Khedkar ,  Ramakrishnan Melarkode ,  Ramavana Gururaja ,  Shrikumar Suryanarayan

发明人： Madhav Kulkarni ,  Surekha K. Prabhu ,  Madenahally Channabasappa Shivakumar ,  Prijyajit Sengupta ,  Sanjay Tiwari ,  Rakesh Mendhe ,  Nitin Patil ,  Laxmi Adhikary ,  Anand Khedkar ,  Ramakrishnan Melarkode ,  Ramavana Gururaja ,  Shrikumar Suryanarayan

IPC分类号： C07D491/18 ,  C12P1/04 ,  C12P17/18

CPC分类号： C12R1/465 ,  C12P17/188

摘要： The present invention discloses a new strain of Streptomyces sp. BICC 7522, its variants or mutants and use of the strain for the production of macrolides, process of production and purification of macrolides.

摘要翻译： 本发明公开了一种新的Streptomyces sp。 BICC 7522，其变体或突变体以及该菌株用于生产大环内酯类，大环内酯类的生产和纯化方法。

公开(公告)号：US20080286842A1

公开(公告)日：2008-11-20

申请号：US11578108

申请日：2004-04-12

申请人： Madhav Kulkarni ,  Surekha K. Prabhu ,  M.C. Shivakumar ,  Prijyajit Sengupta ,  Sanjay Tiwari ,  Rakesh Mendhe ,  Nitin Patil ,  Laxmi Adhikary ,  Anand Khedkar ,  Ramakrishnan Melarkode ,  Ramavana Gururaja ,  Shrikumar Suryanarayan

发明人： Madhav Kulkarni ,  Surekha K. Prabhu ,  M.C. Shivakumar ,  Prijyajit Sengupta ,  Sanjay Tiwari ,  Rakesh Mendhe ,  Nitin Patil ,  Laxmi Adhikary ,  Anand Khedkar ,  Ramakrishnan Melarkode ,  Ramavana Gururaja ,  Shrikumar Suryanarayan

IPC分类号： C12P17/00 ,  C12N1/20 ,  C07D498/00

CPC分类号： C12R1/465 ,  C12P17/188

摘要： The present invention discloses a new strain of Streptomyces sp. BICC 7522, its variants or mutants and use of the strain for the production of macrolides, process of production and purification of microlides.

摘要翻译： 本发明公开了一种新的Streptomyces sp。 BICC 7522，其变体或突变体以及该菌株用于生产大环内酯类物质，生产和纯化微藻的过程。

公开(公告)号：US20130291679A1

公开(公告)日：2013-11-07

申请号：US13462448

申请日：2012-05-02

申请人： Jeffrey Paul Sayre ,  Shrikrishna Madhav Kulkarni

发明人： Jeffrey Paul Sayre ,  Shrikrishna Madhav Kulkarni

IPC分类号： F16P3/00 ,  B21D39/03

CPC分类号： E02F9/0858 ,  E02F9/2267 ,  E02F9/24 ,  F15B13/0825 ,  F15B13/0842 ,  Y10T29/49826 ,  Y10T74/219

摘要： A load isolating device may be defined by a plate-style bracket having a planar body and a plurality of tabs arranged about the body. Each tab may define a peripheral extremity of the body, extending outwardly thereof and situated substantially within the same plane as the body. Each tab may have a particular width, and may include a neck defined by a fillet having a predetermined radius, both tab width and fillet radius being sized and configured to absorb load forces through elastic deformation. As such, the tabs may elastically deform under load to minimize any deformation of the planar body of the device, which in the disclosed embodiment may be formed of an elastic metal plate. Each tab may have the same thickness as the planar body, and both the tabs and the planar body of the device may comprise the same material.

摘要翻译： 负载隔离装置可以由具有平面主体和围绕主体布置的多个突片的板式支架限定。 每个翼片可以限定身体​​的外围末端，其向外延伸并且基本上位于与身体相同的平面内。 每个翼片可以具有特定的宽度，并且可以包括由具有预定半径的圆角限定的颈部，凸片宽度和圆角半径的尺寸和构造被设计成通过弹性变形来吸收载荷力。 这样，突片可以在负载下弹性地变形，以最小化装置的平面主体的任何变形，其在所公开的实施例中可以由弹性金属板形成。 每个突片可以具有与平面主体相同的厚度，并且装置的突片和平面主体可以包括相同的材料。

公开(公告)号：US08936228B2

公开(公告)日：2015-01-20

申请号：US13462448

申请日：2012-05-02

申请人： Jeffrey Paul Sayre ,  Shrikrishna Madhav Kulkarni

发明人： Jeffrey Paul Sayre ,  Shrikrishna Madhav Kulkarni

IPC分类号： F16M1/00

CPC分类号： E02F9/0858 ,  E02F9/2267 ,  E02F9/24 ,  F15B13/0825 ,  F15B13/0842 ,  Y10T29/49826 ,  Y10T74/219

摘要： A load isolating device may be defined by a plate-style bracket having a planar body and a plurality of tabs arranged about the body. Each tab may define a peripheral extremity of the body, extending outwardly thereof and situated substantially within the same plane as the body. Each tab may have a particular width, and may include a neck defined by a fillet having a predetermined radius, both tab width and fillet radius being sized and configured to absorb load forces through elastic deformation. As such, the tabs may elastically deform under load to minimize any deformation of the planar body of the device, which in the disclosed embodiment may be formed of an elastic metal plate. Each tab may have the same thickness as the planar body, and both the tabs and the planar body of the device may comprise the same material.

摘要翻译： 负载隔离装置可以由具有平面主体和围绕主体布置的多个突片的板式支架限定。 每个翼片可以限定身体​​的外围末端，其向外延伸并且基本上位于与身体相同的平面内。 每个翼片可以具有特定的宽度，并且可以包括由具有预定半径的圆角限定的颈部，凸片宽度和圆角半径的尺寸和构造被设计成通过弹性变形来吸收载荷力。 因此，突片可以在负载下弹性地变形，以最小化装置的平面主体的任何变形，其在所公开的实施例中可以由弹性金属板形成。 每个突片可以具有与平面主体相同的厚度，并且装置的突片和平面主体可以包括相同的材料。