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公开(公告)号:US20080234183A1
公开(公告)日:2008-09-25
申请号:US10517079
申请日:2003-06-18
申请人: Mattias Hallbrink , Margus Pooga , Madis Metsis , Priit Kogerman , Andreas Valkna , Anne Meikas , Maria Lindgren , Astrid Graslund , Goran Eriksson , Claes Goran Ostensson , Metka Budihna , Matjaz Zorko , Anna Elmquist , Ursel Soomets , Pontus Lundberg , Peter Jarver , Kulliki Saar , Samir El-Andaloussi , Kalle Kilk , Ulo Langel
发明人: Mattias Hallbrink , Margus Pooga , Madis Metsis , Priit Kogerman , Andreas Valkna , Anne Meikas , Maria Lindgren , Astrid Graslund , Goran Eriksson , Claes Goran Ostensson , Metka Budihna , Matjaz Zorko , Anna Elmquist , Ursel Soomets , Pontus Lundberg , Peter Jarver , Kulliki Saar , Samir El-Andaloussi , Kalle Kilk , Ulo Langel
IPC分类号: A61K38/16 , C12Q1/02 , C07K7/06 , C07K7/08 , C07K14/00 , A61K31/7052 , A61P25/00 , A61P35/00 , A61P9/00 , A61P31/00 , A61P3/10 , C12N9/00 , C12N15/63 , A61K38/08 , A61K38/10
CPC分类号: C07K14/4711 , A61K38/00 , A61K51/0448 , C07K7/06 , C07K7/08 , C07K14/4702 , C07K14/705 , C07K14/72 , C12N15/87
摘要: The present invention relates to a method for predicting or designing, detecting, and/or verifying a novel cell-penetrating peptide (CPP) and to a method for using said new CPP and/or a novel usage of a known CPP for an improved cellular uptake of a cellular effector, coupled to said CPP. Furthermore, the present invention also relates to a method for predicting or designing, detecting and/or verifying a novel cell-penetrating peptide (CPP) that mimics cellular effector activity and/or inhibits cellular effector activity. The present invention additionally relates to the use of said CPP for treating and/or preventing a medical condition and to the use of said CPP for the manufacture of a pharmaceutical composition for treating a medical condition.
摘要翻译: 本发明涉及一种用于预测或设计,检测和/或验证新型细胞穿透肽(CPP)的方法和用于使用所述新CPP的方法和/或用于改进的细胞的已知CPP的新用途 吸收与所述CPP偶联的细胞效应物。 此外,本发明还涉及用于预测或设计,检测和/或验证模拟细胞效应子活性和/或抑制细胞效应子活性的新型细胞穿透肽(CPP)的方法。 本发明还涉及所述CPP用于治疗和/或预防医疗状况以及使用所述CPP来制造治疗医疗状况的药物组合物的用途。