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    Tarp promoter and uses thereof
    2.
    发明申请
    Tarp promoter and uses thereof 审中-公开
    Tarp促进剂及其用途

    公开(公告)号：US20070032439A1

    公开(公告)日：2007-02-08

    申请号：US10542195

    申请日：2004-01-14

    申请人： Magnus Essand

    发明人： Magnus Essand

    IPC分类号： A61K48/00 ,  C12N15/09

    CPC分类号： C12N15/86 ,  A61K48/00 ,  A61K48/0058 ,  C07K14/7051 ,  C12N15/85 ,  C12N15/8509 ,  C12N2710/10343 ,  C12N2830/002 ,  C12N2830/008 ,  C12N2830/40

    摘要： A method of providing expression of a molecule in a prostate cell, prostate cancer cell or breast cancer cell comprises introducing into the cell a TARP promoter or a transcriptionally active fragment thereof, operatively linked to a heterologous polynucleotide that codes for the molecule, under conditions effective to direct expression of the molecule in the cell. A method of treating or preventing a prostate-related or breast-related disorder comprises introducing into a cell of a subject in need thereof a TARP promoter, or a transcriptionally active fragment thereof, operatively linked to a heterologous polynucleotide that codes for a molecule capable of killing the cell or capable of preventing the disorder. An isolated polynucleotide sequence comprises a TARP promoter, or a transcriptionally active fragment thereof, operatively linked to a heterologous expressible nucleotide sequence, or operatively linked to other expression control sequences.

    摘要翻译： 在前列腺细胞，前列腺癌细胞或乳腺癌细胞中提供分子表达的方法包括在条件有效的情况下将有效连接于编码分子的异源多核苷酸的TARP启动子或其转录活性片段引入细胞 以指导细胞中的分子表达。 治疗或预防前列腺相关或乳腺相关病症的方法包括向有需要的受试者的细胞中引入可操作地连接到异源多核苷酸的TARP启动子或其转录活性片段，所述异源多核苷酸编码能够 杀死细胞或能够预防病症。 分离的多核苷酸序列包含可操作地连接到异源可表达核苷酸序列或可操作地连接到其他表达控制序列的TARP启动子或其转录活性片段。

    T-cell receptorγ alternate reading frame protein, (TARP) and uses thereof
    4.
    发明授权
    T-cell receptorγ alternate reading frame protein, (TARP) and uses thereof 有权
    T细胞接受体交替阅读框蛋白（TARP）及其用途

    公开(公告)号：US07052703B1

    公开(公告)日：2006-05-30

    申请号：US10031158

    申请日：2000-07-12

    申请人： Ira Pastan ,  Magnus Essand ,  Byungkook Lee ,  George Vasmatzis ,  Curt Wolfgang ,  Ulrich Brinkmann

    发明人： Ira Pastan ,  Magnus Essand ,  Byungkook Lee ,  George Vasmatzis ,  Curt Wolfgang ,  Ulrich Brinkmann

    IPC分类号： A61K39/00

    CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00

    摘要： This invention provides nucleic acids containing sequences from a TCRγ transcript from prostate epithelial cells and many breast cancer cells and a T-cell receptor gamma Alternate Reading frame Protein (“TARP”) expressed from the translation of those sequences. Vaccines made from TARP are useful in raising immune responses to cells in which the protein is expressed, including prostate cancer cells and cells of many breast cancers. The invention also provides methods for diagnosing the presence of prostate cancer and TARP-expressing breast cancers, as well as methods of administering TARP and nucleic acids encoding TARP to subjects.

    摘要翻译： 本发明提供了含有来自前列腺上皮细胞的TCRγ转录物和许多乳腺癌细胞的序列的核酸，以及从这些序列翻译表达的T细胞受体γ替代阅读框架蛋白（“TARP”）。 由TARP制成的疫苗可用于提高蛋白质表达细胞的免疫应答，包括前列腺癌细胞和许多乳腺癌细胞。 本发明还提供了用于诊断前列腺癌和TARP表达乳腺癌的存在的方法，以及将TARP和编码TARP的核酸给予受试者的方法。