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公开(公告)号：US20100292197A1
公开(公告)日：2010-11-18
申请号：US12781515
申请日：2010-05-17
申请人： Calvin B. Harley , Soo-Peang Khor , Mahesh Ramaseshan , Premchandran Ramiya , Zhu Zhen Pirot , Steven Fauce , Tong Lin
发明人： Calvin B. Harley , Soo-Peang Khor , Mahesh Ramaseshan , Premchandran Ramiya , Zhu Zhen Pirot , Steven Fauce , Tong Lin
IPC分类号： A61K31/58 , C07J53/00 , A61P1/00 , A61P9/00 , A61P17/02 , A61P35/00 , A61P31/18 , A61P25/28 , A61P19/00 , A61P11/00 , C12N5/02
CPC分类号： A61K31/58 , A61K31/56 , C07J17/00 , C07J53/004
摘要： The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.
摘要翻译： 本发明涉及增加细胞中端粒酶活性的方法和组合物。 这样的组合物包括药物制剂。 所述方法和组合物可用于通过在患者的细胞或组织中端粒酶活性的增加来治疗受治疗的疾病。 它们也可用于增强培养细胞的复制能力，如离体细胞治疗和增强干细胞和祖细胞的增殖。
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公开(公告)号：US08481721B2
公开(公告)日：2013-07-09
申请号：US12781515
申请日：2010-05-17
申请人： Calvin B. Harley , Soo-Peang Khor , Mahesh Ramaseshan , Premchandran Ramiya , Zhu Zhen Pirot , Steven Fauce , Tong Lin
发明人： Calvin B. Harley , Soo-Peang Khor , Mahesh Ramaseshan , Premchandran Ramiya , Zhu Zhen Pirot , Steven Fauce , Tong Lin
CPC分类号： A61K31/58 , A61K31/56 , C07J17/00 , C07J53/004
摘要： The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.
摘要翻译： 本发明涉及增加细胞中端粒酶活性的方法和组合物。 这样的组合物包括药物制剂。 所述方法和组合物可用于通过在患者的细胞或组织中端粒酶活性的增加来治疗受治疗的疾病。 它们也可用于增强培养细胞的复制能力，如离体细胞治疗和增强干细胞和祖细胞的增殖。
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公开(公告)号：US08222384B2
公开(公告)日：2012-07-17
申请号：US12434758
申请日：2009-05-04
CPC分类号： C07K14/475 , C07K14/51 , C07K16/18 , C07K2319/00
摘要： Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasting syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity), and bone degenerative diseases (such as osteoporosis).
摘要翻译： 公开了生长分化因子蛋白如GDF-8和骨形态发生蛋白-11的修饰和稳定的前肽。 还公开了制备和使用经修饰的前肽以预防或治疗其中肌肉组织增加在治疗上有益的人或动物疾病的方法。 这些疾病包括肌肉或神经肌肉疾病（如肌萎缩性侧索硬化，肌营养不良，肌肉萎缩，充血性阻塞性肺疾病，肌肉萎缩综合征，肌营养不良或恶病质），代谢疾病或病症（例如2型糖尿病， 依赖性糖尿病，高血糖或肥胖），脂肪组织障碍（如肥胖症）和骨退行性疾病（如骨质疏松症）。
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公开(公告)号：US07737116B2
公开(公告)日：2010-06-15
申请号：US11614702
申请日：2006-12-21
CPC分类号： C07K14/475 , C07K14/51 , C07K16/18 , C07K2319/00
摘要： Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasting syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity), and bone degenerative diseases (such as osteoporosis).
摘要翻译： 公开了生长分化因子蛋白如GDF-8和骨形态发生蛋白-11的修饰和稳定的前肽。 还公开了制备和使用经修饰的前肽以预防或治疗其中肌肉组织增加在治疗上有益的人或动物疾病的方法。 这些疾病包括肌肉或神经肌肉疾病（如肌萎缩性侧索硬化，肌营养不良，肌肉萎缩，充血性阻塞性肺疾病，肌肉萎缩综合征，肌营养不良或恶病质），代谢疾病或病症（例如2型糖尿病， 依赖性糖尿病，高血糖或肥胖），脂肪组织障碍（如肥胖症）和骨退行性疾病（如骨质疏松症）。
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公开(公告)号：US07202210B2
公开(公告)日：2007-04-10
申请号：US10071499
申请日：2002-02-08
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/02 , C12N5/06 , C07K14/475
CPC分类号： C07K14/475 , C07K14/51 , C07K16/18 , C07K2319/00
摘要： Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasting syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity), and bone degenerative diseases (such as osteoporosis).
摘要翻译： 公开了生长分化因子蛋白如GDF-8和骨形态发生蛋白-11的修饰和稳定的前肽。 还公开了制备和使用经修饰的前肽以预防或治疗其中肌肉组织增加在治疗上有益的人或动物疾病的方法。 这些疾病包括肌肉或神经肌肉疾病（如肌萎缩性侧索硬化，肌营养不良，肌肉萎缩，充血性阻塞性肺疾病，肌肉萎缩综合征，肌营养不良或恶病质），代谢疾病或病症（例如2型糖尿病， 依赖性糖尿病，高血糖或肥胖），脂肪组织障碍（如肥胖症）和骨退行性疾病（如骨质疏松症）。
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公开(公告)号：US08710025B2
公开(公告)日：2014-04-29
申请号：US13523391
申请日：2012-06-14
CPC分类号： C07K14/475 , C07K14/51 , C07K16/18 , C07K2319/00
摘要： Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasting syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity), and bone degenerative diseases (such as osteoporosis).
摘要翻译： 公开了生长分化因子蛋白如GDF-8和骨形态发生蛋白-11的修饰和稳定的前肽。 还公开了制备和使用经修饰的前肽以预防或治疗其中肌肉组织增加在治疗上有益的人或动物疾病的方法。 这些疾病包括肌肉或神经肌肉疾病（如肌萎缩性侧索硬化，肌营养不良，肌肉萎缩，充血性阻塞性肺疾病，肌肉萎缩综合征，肌营养不良或恶病质），代谢疾病或病症（例如2型糖尿病， 依赖性糖尿病，高血糖或肥胖），脂肪组织障碍（如肥胖症）和骨退行性疾病（如骨质疏松症）。
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公开(公告)号：US20100305194A1
公开(公告)日：2010-12-02
申请号：US12434758
申请日：2009-05-04
IPC分类号： A61K31/7088 , C07H21/04 , C07K1/00 , A61P21/00 , A61P3/10 , A61P3/04 , A61P19/02 , C12N15/63 , C12N1/00
CPC分类号： C07K14/475 , C07K14/51 , C07K16/18 , C07K2319/00
摘要： Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasting syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity), and bone degenerative diseases (such as osteoporosis).
摘要翻译： 公开了生长分化因子蛋白如GDF-8和骨形态发生蛋白-11的修饰和稳定的前肽。 还公开了制备和使用经修饰的前肽以预防或治疗其中肌肉组织增加在治疗上有益的人或动物疾病的方法。 这些疾病包括肌肉或神经肌肉疾病（如肌萎缩性侧索硬化，肌营养不良，肌肉萎缩，充血性阻塞性肺疾病，肌肉萎缩综合征，肌营养不良或恶病质），代谢疾病或病症（例如2型糖尿病， 依赖性糖尿病，高血糖或肥胖），脂肪组织障碍（如肥胖症）和骨退行性疾病（如骨质疏松症）。
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公开(公告)号：US07560441B2
公开(公告)日：2009-07-14
申请号：US11614594
申请日：2006-12-21
CPC分类号： C07K14/475 , C07K14/51 , C07K16/18 , C07K2319/00
摘要： Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasting syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity), and bone degenerative diseases (such as osteoporosis).
摘要翻译： 公开了生长分化因子蛋白如GDF-8和骨形态发生蛋白-11的修饰和稳定的前肽。 还公开了制备和使用经修饰的前肽以预防或治疗其中肌肉组织增加在治疗上有益的人或动物疾病的方法。 这些疾病包括肌肉或神经肌肉疾病（例如肌萎缩性侧索硬化症，肌营养不良症，肌肉萎缩，充血性阻塞性肺病，肌肉萎缩综合症，肌营养不良或恶病质），代谢疾病或病症（如2型糖尿病，非胰岛素依赖性糖尿病 高血糖或肥胖），脂肪组织障碍（如肥胖症）和骨退行性疾病（如骨质疏松症）。
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公开(公告)号：US20120252884A1
公开(公告)日：2012-10-04
申请号：US13523391
申请日：2012-06-14
IPC分类号： A61K48/00 , C12N15/63 , C12N5/10 , A61P19/08 , A61P21/00 , A61P11/00 , A61P3/00 , C12N15/12 , C07K16/46
CPC分类号： C07K14/475 , C07K14/51 , C07K16/18 , C07K2319/00
摘要： Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasting syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity), and bone degenerative diseases (such as osteoporosis).
摘要翻译： 公开了生长分化因子蛋白如GDF-8和骨形态发生蛋白-11的修饰和稳定的前肽。 还公开了制备和使用经修饰的前肽以预防或治疗其中肌肉组织增加在治疗上有益的人或动物疾病的方法。 这些疾病包括肌肉或神经肌肉疾病（如肌萎缩性侧索硬化，肌营养不良，肌肉萎缩，充血性阻塞性肺疾病，肌肉萎缩综合征，肌营养不良或恶病质），代谢疾病或病症（例如2型糖尿病， 依赖性糖尿病，高血糖或肥胖），脂肪组织障碍（如肥胖症）和骨退行性疾病（如骨质疏松症）。
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公开(公告)号：US20070238683A1
公开(公告)日：2007-10-11
申请号：US11614594
申请日：2006-12-21
申请人： Neil Wolfman , Soo-Peang Khor , Kathleen Tomkinson
发明人： Neil Wolfman , Soo-Peang Khor , Kathleen Tomkinson
IPC分类号： A61K31/7052 , C07H21/04 , C12N15/00 , C12N5/06
CPC分类号： C07K14/475 , C07K14/51 , C07K16/18 , C07K2319/00
摘要： Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasting syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity), and bone degenerative diseases (such as osteoporosis).
摘要翻译： 公开了生长分化因子蛋白如GDF-8和骨形态发生蛋白-11的修饰和稳定的前肽。 还公开了制备和使用经修饰的前肽以预防或治疗其中肌肉组织增加在治疗上有益的人或动物疾病的方法。 这些疾病包括肌肉或神经肌肉疾病（例如肌萎缩性侧索硬化症，肌营养不良症，肌肉萎缩，充血性阻塞性肺病，肌肉萎缩综合症，肌营养不良或恶病质），代谢疾病或病症（如2型糖尿病，非胰岛素依赖性糖尿病 高血糖或肥胖），脂肪组织障碍（如肥胖症）和骨退行性疾病（如骨质疏松症）。
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