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1.
公开(公告)号:US20090137817A1
公开(公告)日:2009-05-28
申请号:US12197610
申请日:2008-08-25
申请人: Pierre Deslongchamps , Yves Dory , Kamel Benakli , Eric Marsault , Luc Ouellet , Mahesh Ramaseshan , Martin Vezina , Daniel Fortin , Ruoxi Lan , Shigui Li , Gerald Villeneuve , Hamid R. Hoveyda , Sylvie Beaubien , Mark L. Peterson
发明人: Pierre Deslongchamps , Yves Dory , Kamel Benakli , Eric Marsault , Luc Ouellet , Mahesh Ramaseshan , Martin Vezina , Daniel Fortin , Ruoxi Lan , Shigui Li , Gerald Villeneuve , Hamid R. Hoveyda , Sylvie Beaubien , Mark L. Peterson
IPC分类号: C07D277/20 , C07D233/66 , C07D263/30
CPC分类号: C07K5/0808 , C07K5/0812 , C07K5/0821 , C07K5/0827
摘要: Novel spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
摘要翻译: 公开了含有特定构象控制元件的新的空间定义的大环化合物。 然后使用这些大环的文库来选择一种或多种与特定生物目标具有特异性相互作用的大环类物质。 特别地,根据本发明的化合物被公开为哺乳动物胃动素受体和哺乳动物生长素释放肽受体的激动剂或拮抗剂。
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公开(公告)号:US20090042953A1
公开(公告)日:2009-02-12
申请号:US12099123
申请日:2008-04-07
申请人: James B. JAQUITH , Gerald VILLENEUVE , Alain BOUDREAULT , Stephen J. MORRIS , Jon DURKIN , John W. GILLARD , Kimberley E. HEWITT , H. Nicholas MARSH
发明人: James B. JAQUITH , Gerald VILLENEUVE , Alain BOUDREAULT , Stephen J. MORRIS , Jon DURKIN , John W. GILLARD , Kimberley E. HEWITT , H. Nicholas MARSH
IPC分类号: A61K31/433 , C07D513/04 , A61P25/28
CPC分类号: C07D513/04
摘要: This invention relates to compounds of Formula I and the use of compounds of Formula I as neuroprotective agents in the treatment of neuronal disorders of the central and peripheral nervous systems. Formula I:
摘要翻译: 本发明涉及式I化合物和式I化合物作为神经保护剂用于治疗中枢和周围神经系统的神经元紊乱的用途。 公式I:
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公开(公告)号:US20050119169A1
公开(公告)日:2005-06-02
申请号:US10911219
申请日:2004-08-02
申请人: Pierre Deslongchamps , Yves Dory , Luc Ouellet , Gerald Villeneuve , Mahesh Ramaseshan , Daniel Fortin , Mark Peterson , Hamid Hoveyda , Sylvie Beaubien , Eric Marsault
发明人: Pierre Deslongchamps , Yves Dory , Luc Ouellet , Gerald Villeneuve , Mahesh Ramaseshan , Daniel Fortin , Mark Peterson , Hamid Hoveyda , Sylvie Beaubien , Eric Marsault
IPC分类号: A61K38/12 , C07D491/02 , C07K1/04 , C07K5/00 , C07K5/08
CPC分类号: C07K1/047 , C07K5/0802
摘要: Novel spatially-defined macrocyclic compounds incorporating peptide bond surrogates are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
摘要翻译: 公开了引入肽键代用品的新型空间定义的大环化合物。 然后使用这些大环的文库来选择一种或多种与特定生物目标具有特异性相互作用的大环类物质。 特别地,根据本发明的化合物被公开为哺乳动物胃动素受体和哺乳动物生长素释放肽受体的激动剂或拮抗剂。
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公开(公告)号:US07772260B2
公开(公告)日:2010-08-10
申请号:US11399033
申请日:2006-04-06
申请人: James B. Jaquith , Gerald Villeneuve , Alain Boudreault , Stephen J. Morris , Jon Durkin , John W. Gillard , Kimberley E. Hewitt , H. Nicholas Marsh
发明人: James B. Jaquith , Gerald Villeneuve , Alain Boudreault , Stephen J. Morris , Jon Durkin , John W. Gillard , Kimberley E. Hewitt , H. Nicholas Marsh
CPC分类号: C07D513/04
摘要: This invention relates to compounds of Formula I and the use of compounds of Formula I as neuroprotective agents in the treatment of neuronal disorders of the central and peripheral nervous systems. Formula I:
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公开(公告)号:US5758390A
公开(公告)日:1998-06-02
申请号:US786566
申请日:1997-01-21
申请人: Gerald Villeneuve
发明人: Gerald Villeneuve
CPC分类号: B65D63/1072 , B65D63/1081 , Y02W30/807 , Y10T24/1498 , Y10T24/153
摘要: A cable tie which can be used for bundling electrical wires or many other objects. The cable tie of this invention comprises an elongate strap of plastic material composed of a longitudinal channel on one side and transversal notches on the other. This cable tie secures the wires by inserting its tail through either side of its block head. When the tail of the cable tie is inserted into the aperture located on a first side of the block head, the said cable tie becomes locked and impossible to be open (not re-usable). However, when the tail of the cable tie is inserted into the aperture located on the opposite side of the block head, the said cable tie becomes locked but re-usable by using a lever arm mechanism to release the elongate strap from the block head and open the cable tie.
摘要翻译: 可用于捆绑电线或许多其他物体的电缆扎带。 本发明的电缆扎带包括由一侧的纵向通道和另一侧上的横向槽口组成的塑料材料的细长带。 该电缆扎带通过将其尾部插入其阻挡头的任一侧来固定电线。 当电缆扎带的尾部插入到位于块头的第一侧的孔中时,所述电缆扎带被锁定并且不可能打开(不可重复使用)。 然而,当电缆扎带的尾部插入到位于块头的相对侧上的孔中时,所述电缆扎带变得锁定,但是通过使用杠杆臂机构可以重新使用以将细长带从块头释放,并且 打开电缆扎带。
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公开(公告)号:US07741349B2
公开(公告)日:2010-06-22
申请号:US11399010
申请日:2006-04-05
申请人: James B. Jaquith , Gerald Villeneuve , Alain Boudreault , Stephen J. Morris , Jon Durkin , John W. Gillard , Kimberley Hewitt , H. Nicholas Marsh
发明人: James B. Jaquith , Gerald Villeneuve , Alain Boudreault , Stephen J. Morris , Jon Durkin , John W. Gillard , Kimberley Hewitt , H. Nicholas Marsh
CPC分类号: C07D513/04
摘要: This invention relates to compounds of Formula I and the use of compounds of Formula I as neuroprotective agents in the treatment of neuronal disorders of the central and peripheral nervous systems. Formula I:
摘要翻译: 本发明涉及式I化合物和式I化合物作为神经保护剂用于治疗中枢和周围神经系统的神经元紊乱的用途。 公式I:
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7.
公开(公告)号:US20090312540A1
公开(公告)日:2009-12-17
申请号:US12471978
申请日:2009-05-26
申请人: Pierre Deslongchamps , Yves Dory , Luc Ouellet , Gerald Villeneuve , Mahesh Ramaseshan , Daniel Fortin , Mark L. Peterson , Hamid R. Hoveyda , Sylvie Beaubien , Eric Marsault , Graeme L. Fraser
发明人: Pierre Deslongchamps , Yves Dory , Luc Ouellet , Gerald Villeneuve , Mahesh Ramaseshan , Daniel Fortin , Mark L. Peterson , Hamid R. Hoveyda , Sylvie Beaubien , Eric Marsault , Graeme L. Fraser
IPC分类号: C07D245/06 , C07D273/00 , C07D285/00
CPC分类号: C07K1/047 , C07K5/0802
摘要: Novel spatially-defined macrocyclic compounds incorporating peptide bond surrogates are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target, in particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
摘要翻译: 公开了引入肽键代用品的新型空间定义的大环化合物。 然后使用这些大环的文库来选择与特定生物靶表现出特异性相互作用的一个或多个大环类物质,特别地,根据本发明的化合物公开为哺乳动物胃动素受体和哺乳动物生长素释放肽受体的激动剂或拮抗剂。
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公开(公告)号:US20070088059A1
公开(公告)日:2007-04-19
申请号:US11399033
申请日:2006-04-06
申请人: James Jaquith , Gerald Villeneuve , Alain Boudreault , Stephen Morris , Jon Durkin , John Gillard , Kimberley Hewitt , H. Marsh
发明人: James Jaquith , Gerald Villeneuve , Alain Boudreault , Stephen Morris , Jon Durkin , John Gillard , Kimberley Hewitt , H. Marsh
IPC分类号: A61K31/433 , C07D498/04
CPC分类号: C07D513/04
摘要: This invention relates to compounds of Formula I and the use of compounds of Formula I as neuroprotective agents in the treatment of neuronal disorders of the central and peripheral nervous systems. Formula I:
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公开(公告)号:US20050069492A1
公开(公告)日:2005-03-31
申请号:US10498548
申请日:2002-12-16
申请人: James Jaquith , Gerald Villeneuve , Alain Boudreault , Stephen Morris , Jon Durkin , John Gillard , Kimberly Hewitt , H. Marsh
发明人: James Jaquith , Gerald Villeneuve , Alain Boudreault , Stephen Morris , Jon Durkin , John Gillard , Kimberly Hewitt , H. Marsh
IPC分类号: A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/497 , A61K31/5377 , A61K31/538 , A61K31/69 , A61P1/16 , A61P3/10 , A61P9/10 , A61P9/12 , A61P21/04 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/06 , A61P31/18 , A61P31/22 , A61P43/00 , C07D513/04 , A61M36/14
CPC分类号: C07D513/04
摘要: This invention relates to compounds of Formula (I) and the use of compounds of Formula (I) as neuroprotective agents in the treatment of neuronal disorders of the central and peripheral nervous systems.
摘要翻译: 本发明涉及式(I)化合物和式(I)化合物作为神经保护剂用于治疗中枢和周围神经系统神经元疾病的用途。
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公开(公告)号:US20070021416A1
公开(公告)日:2007-01-25
申请号:US11398806
申请日:2006-04-06
申请人: James Jaquith , Gerald Villeneuve , Alain Boudreault , Stephen Morris , Jon Durkin , John Gillard , Kimberley Hewitt , H. Marsh
发明人: James Jaquith , Gerald Villeneuve , Alain Boudreault , Stephen Morris , Jon Durkin , John Gillard , Kimberley Hewitt , H. Marsh
IPC分类号: A61K31/5377 , C07D498/04
CPC分类号: C07D513/04
摘要: This invention relates to compounds of Formula I and the use of compounds of Formula I as neuroprotective agents in the treatment of neuronal disorders of the central and peripheral nervous systems. Formula I:
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