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公开(公告)号：US20130190340A1
公开(公告)日：2013-07-25
申请号：US13805508
申请日：2011-06-30
IPC分类号： C07C279/14 , C07C211/12 , C07C65/40 , C07D239/49 , C07D271/12
CPC分类号： C07C279/14 , A61K31/4184 , A61K31/505 , A61K47/54 , A61K47/542 , A61K47/545 , C07C65/40 , C07C211/12 , C07D239/49 , C07D271/12 , Y02A50/469
摘要： Certain aspects of the invention relate to compounds, compositions and methods that are useful for treating or preventing a disease in a subject by enhancing the degradation of a protein. In other aspects, said compounds can be useful research tools for investigating protein degradation. In other aspects, said compounds are useful research tools for investigating protein function. In certain embodiments, the degraded protein is implicated in a disease or disorder whose pathology is related at least in part to the excessive expression of the protein or the expression of a mutant form of the protein.
摘要翻译： 本发明的某些方面涉及可用于通过增强蛋白质降解来治疗或预防受试者的疾病的化合物，组合物和方法。 在其他方面，所述化合物可用于研究蛋白质降解的有用的研究工具。 在其他方面，所述化合物是调查蛋白质功能的有用的研究工具。 在某些实施方案中，降解的蛋白质涉及疾病或病症，其疾病或病症至少部分地与蛋白质的过度表达或蛋白质的突变形式的表达相关。
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公开(公告)号：US09765019B2
公开(公告)日：2017-09-19
申请号：US13805508
申请日：2011-06-30
IPC分类号： A01N43/54 , C07D239/42 , C07D401/04 , C07C279/14 , A61K31/4184 , A61K31/505 , C07C65/40 , C07C211/12 , C07D239/49 , C07D271/12 , A61K47/48
CPC分类号： C07C279/14 , A61K31/4184 , A61K31/505 , A61K47/54 , A61K47/542 , A61K47/545 , C07C65/40 , C07C211/12 , C07D239/49 , C07D271/12 , Y02A50/469
摘要： Certain aspects of the invention relate to compounds, compositions and methods that are useful for treating or preventing a disease in a subject by enhancing the degradation of a protein. In other aspects, said compounds can be useful research tools for investigating protein degradation. In other aspects, said compounds are useful research tools for investigating protein function. In certain embodiments, the degraded protein is implicated in a disease or disorder whose pathology is related at least in part to the excessive expression of the protein or the expression of a mutant form of the protein.
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3.发明申请COLLAPSIBLE VANE STRUCTURE AND RELATED METHOD FOR A SHADE FOR AN ARCHITECTURAL OPENING 有权用于建筑开放的阴影的可拆卸的瓦结构和相关方法公开(公告)号：US20110126959A1
公开(公告)日：2011-06-02
申请号：US12958664
申请日：2010-12-02
申请人： Ronald Holt , Marcus Long , Kelly Q. Rahn , Jason T. Throne , Stephen T. Wisecup
发明人： Ronald Holt , Marcus Long , Kelly Q. Rahn , Jason T. Throne , Stephen T. Wisecup
CPC分类号： E06B9/34 , B29C69/001 , B29C2793/0054 , B29C2793/0072 , E06B9/24 , E06B9/264 , E06B9/266 , E06B9/386 , E06B9/40 , E06B9/56 , E06B2009/2405 , Y10T29/39 , Y10T156/1052 , Y10T156/1062 , Y10T156/1064 , Y10T156/1082 , Y10T156/12 , Y10T156/13
摘要： A base structure and associated method for converting the base structure into an operable vane on a shade for an architectural opening. The base structure includes a back sheet and a front sheet attached together in engagement regions spaced along the length of the back sheet and front sheet. The front sheet is separated into front strip sections having a free end. Operating elements are positioned along the back sheet and situated so as to move relative thereto. The operating elements are attached adjacent to a free end of the front strip. Movement of the operating elements actuates the free end of the front strip to move from a closed position to an open position as desired by the user.
摘要翻译： 一种基础结构和相关联的方法，用于将基部结构转换成用于建筑开口的阴凉处的可操作的叶片。 基部结构包括背板和前片，所述背片和前片沿着背片和前片的长度间隔开的接合区域附接在一起。 前片被分成具有自由端的前条带部分。 操作元件沿着底片定位并且相对于其移动。 操作元件邻近前条的自由端附接。 操作元件的移动致动前条带的自由端，以根据用户的需要从关闭位置移动到打开位置。
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公开(公告)号：US08496768B2
公开(公告)日：2013-07-30
申请号：US12958664
申请日：2010-12-02
申请人： Ronald Holt , Marcus Long , Kelly Q. Rahn , Jason T. Throne , Stephen T. Wisecup
发明人： Ronald Holt , Marcus Long , Kelly Q. Rahn , Jason T. Throne , Stephen T. Wisecup
CPC分类号： E06B9/34 , B29C69/001 , B29C2793/0054 , B29C2793/0072 , E06B9/24 , E06B9/264 , E06B9/266 , E06B9/386 , E06B9/40 , E06B9/56 , E06B2009/2405 , Y10T29/39 , Y10T156/1052 , Y10T156/1062 , Y10T156/1064 , Y10T156/1082 , Y10T156/12 , Y10T156/13
摘要： A base structure and associated method for converting the base structure into an operable vane on a shade for an architectural opening. The base structure includes a back sheet and a front sheet attached together in engagement regions spaced along the length of the back sheet and front sheet. The front sheet is separated into front strip sections having a free end. Operating elements are positioned along the back sheet and situated so as to move relative thereto. The operating elements are attached adjacent to a free end of the front strip. Movement of the operating elements actuates the free end of the front strip to move from a closed position to an open position as desired by the user.
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