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公开(公告)号：US08921531B2
公开(公告)日：2014-12-30
申请号：US13395869
申请日：2010-09-13
申请人： Bhami Shenoy , Sibyl Baladi , Reena Patel , Margaret McGrath , Nazer Khalaf , Chanchal Randhawa
发明人： Bhami Shenoy , Sibyl Baladi , Reena Patel , Margaret McGrath , Nazer Khalaf , Chanchal Randhawa
CPC分类号： C07K16/1271 , C07K1/22 , C07K14/31 , C07K2317/24 , C07K2317/55 , C07K2317/622
摘要： Protein A crystals and Protein A cross-linked protein crystals (CLPCs) are described. Methods of preparing and using are also disclosed.
摘要翻译： 描述了蛋白A晶体和蛋白A交联蛋白晶体（CLPC）。 还公开了制备和使用方法。
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公开(公告)号：US07459155B2
公开(公告)日：2008-12-02
申请号：US10977737
申请日：2004-10-29
IPC分类号： A61K38/48
CPC分类号： A61K38/482 , A61K38/1709 , A61K38/465 , A61K38/47 , A61K38/4826 , A61K2300/00
摘要： This invention relates to methods for maintaining the basal level or reducing the level of cholecystokinin (CCK) in blood plasma of a mammal. Additionally, the invention provides methods for treating pain in a mammal and more particularly, methods for treating abdominal pain in a mammal. The methods include administering to the mammal a non-pancreatic protease or a composition comprising a non-pancreatic protease. The methods of this invention are particularly useful for treating abdominal pain in a mammal suffering from acute or chronic pancreatitis and related conditions.
摘要翻译： 本发明涉及维持哺乳动物血浆中基底水平或降低胆囊收缩素（CCK）水平的方法。 另外，本发明提供了治疗哺乳动物疼痛的方法，更具体地，涉及治疗哺乳动物腹痛的方法。 所述方法包括向哺乳动物施用非胰蛋白酶或包含非胰蛋白酶的组合物。 本发明的方法特别可用于治疗患有急性或慢性胰腺炎和相关病症的哺乳动物的腹痛。
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3.发明申请NON-PANCREATIC PROTEASES FOR CONTROLLING PLASMA CHOLECYSTOKININ (CCK) CONCENTRATION AND FOR TREATING PAIN 审中-公开用于控制等离子体CHOINEYSTOKININ（CCK）浓度和治疗疼痛的非胰蛋白酶公开(公告)号：US20090081184A1
公开(公告)日：2009-03-26
申请号：US12258122
申请日：2008-10-24
CPC分类号： A61K38/482 , A61K38/1709 , A61K38/465 , A61K38/47 , A61K38/4826 , A61K2300/00
摘要： This invention relates to methods for maintaining the basal level or reducing the level of cholecystokinin (CCK) in blood plasma of a mammal. Additionally, the invention provides methods for treating pain in a mammal and more particularly, methods for treating abdominal pain in a mammal. The methods include administering to the mammal a non-pancreatic protease or a composition comprising a non-pancreatic protease. The methods of this invention are particularly useful for treating abdominal pain in a mammal suffering from acute or chronic pancreatitis and related conditions.
摘要翻译： 本发明涉及维持哺乳动物血浆中基底水平或降低胆囊收缩素（CCK）水平的方法。 另外，本发明提供了治疗哺乳动物疼痛的方法，更具体地，涉及治疗哺乳动物腹痛的方法。 所述方法包括向哺乳动物施用非胰蛋白酶或包含非胰蛋白酶的组合物。 本发明的方法特别可用于治疗患有急性或慢性胰腺炎和相关病症的哺乳动物的腹痛。
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公开(公告)号：US20110171268A1
公开(公告)日：2011-07-14
申请号：US12934392
申请日：2009-03-24
申请人： Bhami Shenoy , Danica Grujic , Reena Patel , Vinney George , Margaret Mcgrath , Nazer Khalaf , Emma Watson
发明人： Bhami Shenoy , Danica Grujic , Reena Patel , Vinney George , Margaret Mcgrath , Nazer Khalaf , Emma Watson
IPC分类号： A61K38/44 , A61K38/54 , A61K9/00 , A61P3/10 , A61P9/00 , A61P19/06 , A61P9/12 , A61P13/12 , A61P3/00
CPC分类号： A61K45/06 , A61K31/425 , A61K31/52 , A61K33/00 , A61K38/00 , A61K38/44 , C12N9/0046 , C12Y107/03003 , C12Y111/01006 , A61K2300/00
摘要： Compositions containing uricase are disclosed. Methods of treating a disorder associated with elevated uric acid concentrations using uricase are also described. Compositions containing uricase and catalase are also disclosed. Methods of treating a disorder associated with elevated uric acid concentrations using uricase and catalase are also described.
摘要翻译： 公开了含有尿酸酶的组合物。 还描述了使用尿酸酶治疗与升高的尿酸浓度相关的病症的方法。 还公开了含有尿酸酶和过氧化氢酶的组合物。 还描述了使用尿酸酶和过氧化氢酶治疗与升高的尿酸浓度相关的病症的方法。
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公开(公告)号：US20080038246A1
公开(公告)日：2008-02-14
申请号：US11833082
申请日：2007-08-02
申请人： Bhami Shenoy , Teresa Cachero , John Shin , Lekai Zhang , Aftab Rashid , Danica Grujic , Reena Patel , Margaret McGrath
发明人： Bhami Shenoy , Teresa Cachero , John Shin , Lekai Zhang , Aftab Rashid , Danica Grujic , Reena Patel , Margaret McGrath
CPC分类号： A61K38/51 , A61K9/0034 , A61K38/00 , A61M1/16 , A61M1/3687 , A61M2202/0413 , A61M2205/75 , C07K2299/00 , C12N9/88 , C12Q1/527 , C12Y401/01002 , G01N2333/988
摘要： Oxalate decarboxylase crystals, including stabilized crystals, such as cross-linked crystals of oxalate decarboxylase, are disclosed. Methods to treat a disorder associated with elevated oxalate concentration using oxalate decarboxylase crystals are also disclosed. Additionally disclosed are methods of producing protein crystals.
摘要翻译： 公开了草酸脱羧酶晶体，包括稳定的晶体，如草酸脱羧酶的交联晶体。 还公开了使用草酸脱羧酶晶体治疗与草酸盐浓度升高相关的病症的方法。 另外公开了生产蛋白质晶体的方法。
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6.发明申请Non-pancreatic proteases for controlling plasma cholecystokinin (CCK) concentration and for treating pain 有权用于控制血浆胆囊收缩素（CCK）浓度和治疗疼痛的非胰腺蛋白酶公开(公告)号：US20050158299A1
公开(公告)日：2005-07-21
申请号：US10977737
申请日：2004-10-29
申请人： Alexey Margolin , Bhami Shenoy , Margaret McGrath
发明人： Alexey Margolin , Bhami Shenoy , Margaret McGrath
IPC分类号： A61K38/48
CPC分类号： A61K38/482 , A61K38/1709 , A61K38/465 , A61K38/47 , A61K38/4826 , A61K2300/00
摘要： This invention relates to methods for maintaining the basal level or reducing the level of cholecystokinin (CCK) in blood plasma of a mammal. Additionally, the invention provides methods for treating pain in a mammal and more particularly, methods for treating abdominal pain in a mammal. The methods include administering to the mammal a non-pancreatic protease or a composition comprising a non-pancreatic protease. The methods of this invention are particularly useful for treating abdominal pain in a mammal suffering from acute or chronic pancreatitis and related conditions.
摘要翻译： 本发明涉及维持哺乳动物血浆中基底水平或降低胆囊收缩素（CCK）水平的方法。 另外，本发明提供了治疗哺乳动物疼痛的方法，更具体地，涉及治疗哺乳动物腹痛的方法。 所述方法包括向哺乳动物施用非胰蛋白酶或包含非胰蛋白酶的组合物。 本发明的方法特别可用于治疗患有急性或慢性胰腺炎和相关病症的哺乳动物的腹痛。
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公开(公告)号：US20130053548A1
公开(公告)日：2013-02-28
申请号：US13395869
申请日：2010-09-13
申请人： Bhami Shenoy , Sibyl Baladi , Reena Patel , Margaret McGrath , Nazer Khalaf , Chanchal Randhawa
发明人： Bhami Shenoy , Sibyl Baladi , Reena Patel , Margaret McGrath , Nazer Khalaf , Chanchal Randhawa
CPC分类号： C07K16/1271 , C07K1/22 , C07K14/31 , C07K2317/24 , C07K2317/55 , C07K2317/622
摘要： Protein A crystals and Protein A cross-linked protein crystals (CLPCs) are described. Methods of preparing and using are also disclosed.
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