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    Controlled dissolution crosslinked protein in crystals
    5.
    发明申请
    Controlled dissolution crosslinked protein in crystals 审中-公开
    结晶中控释溶解交联蛋白

    公开(公告)号：US20060223156A1

    公开(公告)日：2006-10-05

    申请号：US11312210

    申请日：2005-12-19

    申请人： Alexey Margolin ,  Rose Persichetti ,  Nancy St. Clair ,  Nazer Khalaf ,  Bhami Shenoy

    发明人： Alexey Margolin ,  Rose Persichetti ,  Nancy St. Clair ,  Nazer Khalaf ,  Bhami Shenoy

    IPC分类号： C12N11/00

    CPC分类号： C12N9/54 ,  A23K20/147 ,  A61K8/64 ,  A61Q5/02 ,  A61Q19/00 ,  C07K14/765 ,  C07K2299/00 ,  C11D3/3719 ,  C11D3/38 ,  C11D3/386 ,  C12N9/20 ,  C12N9/92 ,  C12N9/96 ,  C12N11/00 ,  C12Y304/21062 ,  C12Y304/24027 ,  C12Y503/01005 ,  C30B29/58 ,  Y10S530/81

    摘要： The present invention relates to crosslinked protein crystals characterized by the ability to change from insoluble and stable form to soluble and active form upon a change in the environment of said crystals, said change being selected from the group consisting of change in temperature, change in pH, change in chemical composition, change from concentrate to dilute form, change in oxidation-reduction potential of the solution, change in the incident radiation, change in transition metal concentration, change in flouride concentration, change in free radical concentration, change in metal chelater concentration, change in shear force acting upon the crystals and combinations thereof. According to one embodiment of this invention, such crosslinked protein crystals are capable of releasing their protein activity at a controlled rate. This invention also provides methods for producing such crosslinked protein crystals, methods using them for protein delivery and methods using them in cleaning agents, including detergents, pharmaceutical compositions, vaccines, personal care compositions, including cosmetics, veterinary compositions, foods, feeds, diagnostics and formulations for decontamination.

    摘要翻译： 本发明涉及交联的蛋白质晶体，其特征在于在所述晶体的环境变化时从不溶性和稳定形式变为可溶性和活性形式的能力，所述变化选自温度变化，pH变化 化学成分变化，从浓缩物变成稀释形式，溶液的氧化还原电位变化，入射辐射的变化，过渡金属浓度的变化，浓度的变化，自由基浓度的变化，金属螯合剂的变化 浓度，作用于晶体的剪切力的变化及其组合。 根据本发明的一个实施方案，这种交联的蛋白质晶体能够以受控的速率释放其蛋白质活性。 本发明还提供了生产这种交联蛋白质晶体的方法，使用它们进行蛋白质递送的方法以及在清洁剂中使用它们的方法，包括洗涤剂，药物组合物，疫苗，个人护理组合物，包括化妆品，兽医组合物，食品，饲料，诊断和 去污配方。

    Non-pancreatic proteases for controlling plasma cholecystokinin (CCK) concentration and for treating pain
    6.
    发明申请
    Non-pancreatic proteases for controlling plasma cholecystokinin (CCK) concentration and for treating pain 有权
    用于控制血浆胆囊收缩素（CCK）浓度和治疗疼痛的非胰腺蛋白酶

    公开(公告)号：US20050158299A1

    公开(公告)日：2005-07-21

    申请号：US10977737

    申请日：2004-10-29

    申请人： Alexey Margolin ,  Bhami Shenoy ,  Margaret McGrath

    发明人： Alexey Margolin ,  Bhami Shenoy ,  Margaret McGrath

    IPC分类号： A61K38/48

    CPC分类号： A61K38/482 ,  A61K38/1709 ,  A61K38/465 ,  A61K38/47 ,  A61K38/4826 ,  A61K2300/00

    摘要： This invention relates to methods for maintaining the basal level or reducing the level of cholecystokinin (CCK) in blood plasma of a mammal. Additionally, the invention provides methods for treating pain in a mammal and more particularly, methods for treating abdominal pain in a mammal. The methods include administering to the mammal a non-pancreatic protease or a composition comprising a non-pancreatic protease. The methods of this invention are particularly useful for treating abdominal pain in a mammal suffering from acute or chronic pancreatitis and related conditions.

    摘要翻译： 本发明涉及维持哺乳动物血浆中基底水平或降低胆囊收缩素（CCK）水平的方法。 另外，本发明提供了治疗哺乳动物疼痛的方法，更具体地，涉及治疗哺乳动物腹痛的方法。 所述方法包括向哺乳动物施用非胰蛋白酶或包含非胰蛋白酶的组合物。 本发明的方法特别可用于治疗患有急性或慢性胰腺炎和相关病症的哺乳动物的腹痛。

    Compositions and methods for treating pancreatic insufficiency
    8.
    发明申请
    Compositions and methods for treating pancreatic insufficiency 有权
    治疗胰腺功能不全的组合物和方法

    公开(公告)号：US20060121017A1

    公开(公告)日：2006-06-08

    申请号：US11251278

    申请日：2005-10-14

    申请人： Alexey Margolin ,  Bhami Shenoy ,  Frederick Murray

    发明人： Alexey Margolin ,  Bhami Shenoy ,  Frederick Murray

    IPC分类号： A61K38/54 ,  C12N9/20

    CPC分类号： A61K38/48 ,  A61K38/465 ,  A61K38/47 ,  A61K38/54 ,  A61K2300/00

    摘要： The present invention relates to compositions for the treatment of conditions, including pancreatic insufficiency. The compositions of the present invention comprise lipase, protease and amylase in a particular ratio that provides beneficial results in patients, such as those afflicted with pancreatic insufficiency. This invention also relates to methods using such compositions for the treatment of pancreatic insufficiency.

    摘要翻译： 本发明涉及用于治疗包括胰腺功能不全的病症的组合物。 本发明的组合物以特定的比率包含脂肪酶，蛋白酶和淀粉酶，这在患者（例如患有胰腺功能不全的患者）中提供有益的结果。 本发明还涉及使用这种组合物治疗胰腺功能不全的方法。

    Methods of crystallizing antibodies
    9.
    发明授权
    Methods of crystallizing antibodies 有权
    结晶抗体的方法

    公开(公告)号：US09310379B2

    公开(公告)日：2016-04-12

    申请号：US12237917

    申请日：2008-09-25

    申请人： Bhami Shenoy ,  Chandrika P. Govardhan ,  Mark X. Yang ,  Alexey L. Margolin

    发明人： Bhami Shenoy ,  Chandrika P. Govardhan ,  Mark X. Yang ,  Alexey L. Margolin

    IPC分类号： G01N33/68 ,  A61K9/00 ,  A61K9/16 ,  A61K47/10 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  C07K16/00

    CPC分类号： G01N33/6857 ,  A61K9/0019 ,  A61K9/1688 ,  A61K47/10 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  C07K16/00 ,  C07K2299/00 ,  C07K2317/732 ,  C07K2317/734 ,  G01N33/6854 ,  G01N2469/10

    摘要： This invention relates to crystals of whole antibodies and fragments thereof, and formulations and compositions comprising such crystals. More particularly, methods are provided for the crystallization of high concentrations of whole antibodies, and fragments thereof, in large batches, and for the preparation of stabilized whole antibody crystals for use alone, or in dry or slurry formulations or compositions. This invention also relates to methods for stabilization, storage and delivery of biologically active whole antibody crystals. The present invention further relates to methods using whole antibody crystals, antibody fragment crystals, or compositions or formulations comprising such crystals for biomedical applications, including biological delivery to humans and animals. More particularly, whole antibody crystals or antibody fragment crystals, or crystal compositions or formulations thereof, are used as a carrier-free delivery system which can slowly release active whole antibodies or fragments thereof, to a subject, where and when they are needed.

    摘要翻译： 本发明涉及全抗体及其片段的晶体，以及包含这种晶体的制剂和组合物。 更具体地，提供了用于大批量结晶高浓度全抗体及其片段，以及单独使用稳定的全抗体晶体的制备，或在干燥或浆液制剂或组合物中结晶的方法。 本发明还涉及稳定，储存和递送生物活性整体抗体晶体的方法。 本发明还涉及使用全抗体晶体，抗体片段晶体或包含用于生物医学应用的晶体的组合物或制剂，包括向人和动物的生物递送的方法。 更具体地，使用全抗体晶体或抗体片段晶体或其晶体组合物或其制剂作为无载体递送系统，其可以在需要时和时间上缓慢释放活性整体抗体或其片段。