公开(公告)号：US07524650B2

公开(公告)日：2009-04-28

申请号：US10550295

申请日：2004-03-31

申请人： Marie-Anne Petit ,  Colette Jolivet-Reynaud

发明人： Marie-Anne Petit ,  Colette Jolivet-Reynaud

IPC分类号： A61K39/395

CPC分类号： C07K16/109 ,  A61K2039/505 ,  A61K2039/525 ,  A61K2039/5258 ,  C07K14/005 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/32 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C12N7/00 ,  C12N2770/24222 ,  C12N2770/24223 ,  C12N2770/24251

摘要： New conformational antibodies are directed against HCV and more particularly to monoclonal antibodies. Described compositions of particles are liable to be recognized by the antibodies, as are pharmaceutical compositions containing them. Also described are HCV enveloped subviral particles or purified HCV enveloped complete viral particles, and the processes for preparing them.

摘要翻译： 新的构象抗体针对HCV，更具体地针对单克隆抗体。 颗粒的描述组合物易于被抗体识别，含有它们的药物组合物也是如此。 还描述了HCV包膜的亚病毒颗粒或纯化的HCV包膜的完整病毒颗粒及其制备方法。

公开(公告)号：US20070026003A1

公开(公告)日：2007-02-01

申请号：US10550295

申请日：2004-03-31

申请人： Marie-Anne Petit ,  Colette Jolivet-Reynaud

发明人： Marie-Anne Petit ,  Colette Jolivet-Reynaud

IPC分类号： A61K39/42 ,  C12Q1/70 ,  C12N7/00 ,  C07K16/10

CPC分类号： C07K16/109 ,  A61K2039/505 ,  A61K2039/525 ,  A61K2039/5258 ,  C07K14/005 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/32 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C12N7/00 ,  C12N2770/24222 ,  C12N2770/24223 ,  C12N2770/24251

摘要： New conformational antibodies are directed against HCV and more particularly to monoclonal antibodies. Described compositions of particles are liable to be recognized by the antibodies, as are pharmaceutical compositions containing them. Also described are HCV enveloped subviral particles or purified HCV enveloped complete viral particles, and the processes for preparing them.

摘要翻译： 新的构象抗体针对HCV，更具体地针对单克隆抗体。 颗粒的描述组合物易于被抗体识别，含有它们的药物组合物也是如此。 还描述了HCV包膜的亚病毒颗粒或纯化的HCV包膜的完整病毒颗粒，以及它们的制备方法。

公开(公告)号：US08007792B2

公开(公告)日：2011-08-30

申请号：US12408080

申请日：2009-03-20

申请人： Marie-Anne Petit ,  Colette Jolivet-Reynaud ,  Christian Trepo

发明人： Marie-Anne Petit ,  Colette Jolivet-Reynaud ,  Christian Trepo

IPC分类号： A61K39/395

CPC分类号： C07K16/109 ,  A61K2039/505 ,  A61K2039/525 ,  A61K2039/5258 ,  C07K14/005 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/32 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C12N7/00 ,  C12N2770/24222 ,  C12N2770/24223 ,  C12N2770/24251

摘要： New conformational antibodies are directed against HCV and more particularly to monoclonal antibodies. Described compositions of particles are liable to be recognized by the antibodies, as are pharmaceutical compositions containing them. Also described are HCV enveloped subviral particles or purified HCV enveloped complete viral particles, and the processes for preparing them.

摘要翻译： 新的构象抗体针对HCV，更具体地针对单克隆抗体。 颗粒的描述组合物易于被抗体识别，含有它们的药物组合物也是如此。 还描述了HCV包膜的亚病毒颗粒或纯化的HCV包膜的完整病毒颗粒，以及它们的制备方法。

公开(公告)号：US20110311551A1

公开(公告)日：2011-12-22

申请号：US13114229

申请日：2011-05-24

申请人： Marie Anne PETIT ,  Emmanuel DROUET ,  Christian TREPO

发明人： Marie Anne PETIT ,  Emmanuel DROUET ,  Christian TREPO

IPC分类号： A61K39/395 ,  C07K16/46 ,  A61P31/14 ,  C12N15/63 ,  C12N5/10 ,  C12N1/00 ,  C07K16/10 ,  C12N15/13

CPC分类号： C07K16/109 ,  A61K2039/505 ,  A61K2039/525 ,  A61K2039/5258 ,  C07K14/005 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/32 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C12N7/00 ,  C12N2770/24222 ,  C12N2770/24223 ,  C12N2770/24251

摘要： The invention provides new conformational antibodies, and more particular conformational monoclonal antibodies and fragments thereof, that are directed against HCV. Also provided are compositions of particles that are recognized by such antibodies, and pharmaceutical compositions containing these particles. Also described are HCV enveloped subviral particles and purified HCV enveloped complete viral particles, as well as processes for their preparation.

摘要翻译： 本发明提供针对HCV的新构象抗体及更具体的构象单克隆抗体及其片段。 还提供了由这种抗体识别的颗粒的组合物和含有这些颗粒的药物组合物。 还描述了HCV包膜的亚病毒颗粒和纯化的HCV包膜的完整病毒颗粒，以及其制备方法。

公开(公告)号：US20090186023A1

公开(公告)日：2009-07-23

申请号：US12408080

申请日：2009-03-20

申请人： Marie-Anne Petit ,  Colette Jolivet-Raynaud

发明人： Marie-Anne Petit ,  Colette Jolivet-Raynaud

IPC分类号： A61K39/395 ,  C12Q1/70 ,  C07K16/18

CPC分类号： C07K16/109 ,  A61K2039/505 ,  A61K2039/525 ,  A61K2039/5258 ,  C07K14/005 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/32 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C12N7/00 ,  C12N2770/24222 ,  C12N2770/24223 ,  C12N2770/24251

摘要： New conformational antibodies are directed against HCV and more particularly to monoclonal antibodies. Described compositions of particles are liable to be recognized by the antibodies, as are pharmaceutical compositions containing them. Also described are HCV enveloped subviral particles or purified HCV enveloped complete viral particles, and the processes for preparing them.

摘要翻译： 新的构象抗体针对HCV，更具体地针对单克隆抗体。 颗粒的描述组合物易于被抗体识别，含有它们的药物组合物也是如此。 还描述了HCV包膜的亚病毒颗粒或纯化的HCV包膜的完整病毒颗粒及其制备方法。

公开(公告)号：US20130052187A1

公开(公告)日：2013-02-28

申请号：US13616665

申请日：2012-09-14

申请人： Marie Anne PETIT ,  Emmanuel DROUET ,  Christian TREPO

发明人： Marie Anne PETIT ,  Emmanuel DROUET ,  Christian TREPO

IPC分类号： A61K39/395 ,  C07K16/46 ,  C12N15/13 ,  C12N5/18 ,  C12N5/10 ,  A61P31/14 ,  C12N5/12 ,  C07K16/00 ,  C12N15/63

CPC分类号： C07K16/109 ,  A61K2039/505 ,  A61K2039/525 ,  A61K2039/5258 ,  C07K14/005 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/32 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C12N7/00 ,  C12N2770/24222 ,  C12N2770/24223 ,  C12N2770/24251

摘要： New conformational antibodies, and more particular conformational monoclonal antibodies and fragments thereof, are directed against HCV. Also provided are compositions of particles that are recognized by such antibodies, and pharmaceutical compositions containing these particles. Also described are HCV enveloped subviral particles and purified HCV enveloped complete viral particles, as well as processes for their preparation.

摘要翻译： 新的构象抗体和更具体的构象单克隆抗体及其片段针对HCV。 还提供了由这种抗体识别的颗粒的组合物和含有这些颗粒的药物组合物。 还描述了HCV包膜的亚病毒颗粒和纯化的HCV包膜的完整病毒颗粒，以及其制备方法。