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1.发明授权Method for the in vitro diagnosis of bronchopulmonary carcinoma by detection of major alternative transcripts of the KLK8 gene encoding kallikrein 8 and use thereof for prognosticating survival 有权通过检测编码激肽释放酶8的KLK8基因的主要替代转录物进行体外诊断支气管肺癌的方法及其在预后中的应用公开(公告)号：US08236506B2
公开(公告)日：2012-08-07
申请号：US12310622
申请日：2007-09-27
CPC分类号： C12N9/6421 , C12Q1/6886 , C12Q2600/118
摘要： The present invention relates to a method for the in vitro diagnosis of bronchopulmonary carcinoma, in particular of non-small cell bronchial carcinoma, characterized in that it comprises the stage of detecting, in a biological sample derived from a patient suspected to be suffering from said bronchopulmonary carcinoma, at least one of the major alternative transcripts of the KLK8 gene encoding kallikrein 8. This method is particularly useful for the survival prognostication of patients suffering from bronchopulmonary carcinoma.
摘要翻译： 本发明涉及一种用于体外诊断支气管肺癌，特别是非小细胞支气管癌的方法，其特征在于，其包括检测来自疑似患有所述 支气管肺癌，编码激肽释放酶8的KLK8基因的主要替代转录物中的至少一种。该方法对于患有支气管肺癌的患者的生存预后特别有用。
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公开(公告)号：US07479386B2
公开(公告)日：2009-01-20
申请号：US10499805
申请日：2002-12-27
IPC分类号： C12N7/00 , C12N15/33 , C12N5/10 , C12N1/19 , C12N15/09 , C07K14/18 , A61K39/12 , A61K48/00 , C12Q1/70 , C12Q1/68 , C07H21/00
CPC分类号： C07K14/005 , C12N7/00 , C12N2770/24221 , C12N2770/24251
摘要： Isolated HXHV virus having the following characteristics: (i) a DNA genome which is at least partially single-stranded, (ii) the said genome comprises one reading frame (ORF) encoding one protein or one polyprotein (iii) the said genome comprises a nucleotide sequence which exhibits, for any segment of at least 40 nucleotides belonging to the said sequence, at least 90% homology with SEQ ID NO: 1 or with its complementary sequence, nucleic material and peptide material and uses.
摘要翻译： 具有以下特征的分离的HXHV病毒：（i）至少部分单链的DNA基因组，（ii）所述基因组包含编码一种蛋白质或一种多蛋白质的一个阅读框（ORF）（iii）所述基因组包含 核苷酸序列，对于属于所述序列的至少40个核苷酸的任何片段，其显示与SEQ ID NO：1至少90％的同源性，或其互补序列，核酸和肽材料和用途。
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3.发明申请VIRAL MATERIAL AND NUCLEOTIDE FRAGMENTS ASSOCIATED WITH MULTIPLE SCLEROSIS, FOR DIAGNOSTIC, PROPHYLACTIC AND THERAPEUTIC PURPOSES 有权与多发性硬化相关的病理材料和核素片段，用于诊断，预防和治疗目的公开(公告)号：US20070117189A1
公开(公告)日：2007-05-24
申请号：US11463109
申请日：2006-08-08
申请人： Herve PERRON , Frederic Beseme , Frederic Bedin , Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Colette Jolivet-Reynaud , Bernard Mandrand
发明人： Herve PERRON , Frederic Beseme , Frederic Bedin , Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Colette Jolivet-Reynaud , Bernard Mandrand
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/51 , C12N2740/10022 , C12Q1/6883 , C12Q1/702
摘要： Viral material, in the isolated or purified state, in which the genome comprises a nucleotide sequence chosen from the group including sequences SEQ ID NO:46, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53 and SEQ ID NO:56, their complementary sequences and their equivalent sequences, in particular nucleotide sequences displaying, for any succession of 100 contiguous monomers, at least 50% and preferably at least 70% homology with the said sequences SEQ ID NO:46, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53 and SEQ ID NO:56, respectively, and their complementary sequences.
摘要翻译： 分离或纯化状态的病毒物质，其中基因组包含选自SEQ ID NO：46，SEQ ID NO：51，SEQ ID NO：52，SEQ ID NO：53和SEQ ID NO：53的核苷酸序列 SEQ ID NO：46，SEQ ID NO：56，其互补序列及其等同序列，特别是核苷酸序列，显示100个连续单体的任何连续序列，与所述序列SEQ ID NO：46，SEQ ID NO：至少50％，优选至少70％ ：51，SEQ ID NO：52，SEQ ID NO：53和SEQ ID NO：56及其互补序列。
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公开(公告)号：US20050037336A1
公开(公告)日：2005-02-17
申请号：US10499805
申请日：2002-12-27
IPC分类号： G01N33/53 , A61K39/00 , A61K39/29 , A61P1/16 , A61P31/20 , C07K14/005 , C07K14/18 , C07K16/08 , C12N1/19 , C12N5/02 , C12N5/10 , C12N7/00 , C12N7/02 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/68 , C12Q1/70 , A61K39/12 , C07H21/04
CPC分类号： C07K14/005 , C12N7/00 , C12N2770/24221 , C12N2770/24251
摘要： Isolated HXHV virus having the following characteristics: (i) a DNA genome which is at least partially single-stranded, (ii) the said genome comprises one reading frame (ORF) encoding one protein or one polyprotein (iii) the said genome comprises a nucleotide sequence which exhibits, for any segment of at least 40 nucleotides belonging to the said sequence, at least 90% homology with SEQ ID NO: 1 or with its complementary sequence, nucleic material and peptide material and uses.
摘要翻译： 具有以下特征的分离的HXHV病毒：（i）至少部分单链的DNA基因组，（ii）所述基因组包含编码一种蛋白质或一种多蛋白质的一个阅读框（ORF）（iii）所述基因组包含 核苷酸序列，对于属于所述序列的至少40个核苷酸的任何片段，其显示与SEQ ID NO：1至少90％的同源性，或其互补序列，核酸和肽材料和用途。
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5.发明授权Antibodies directed against hepatitis C virus E1E2 complex, compositions of HCV particles, and pharmaceutical compositions 失效针对丙型肝炎病毒E1E2复合物的抗体，HCV颗粒的组合物和药物组合物公开(公告)号：US07524650B2
公开(公告)日：2009-04-28
申请号：US10550295
申请日：2004-03-31
IPC分类号： A61K39/395
CPC分类号： C07K16/109 , A61K2039/505 , A61K2039/525 , A61K2039/5258 , C07K14/005 , C07K2317/21 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C12N7/00 , C12N2770/24222 , C12N2770/24223 , C12N2770/24251
摘要： New conformational antibodies are directed against HCV and more particularly to monoclonal antibodies. Described compositions of particles are liable to be recognized by the antibodies, as are pharmaceutical compositions containing them. Also described are HCV enveloped subviral particles or purified HCV enveloped complete viral particles, and the processes for preparing them.
摘要翻译： 新的构象抗体针对HCV，更具体地针对单克隆抗体。 颗粒的描述组合物易于被抗体识别，含有它们的药物组合物也是如此。 还描述了HCV包膜的亚病毒颗粒或纯化的HCV包膜的完整病毒颗粒及其制备方法。
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6.发明申请Antibodies directed against hepatitis c virus e1e2 complex, compositions of hcv particles, and pharmaceutical compositions 失效针对丙型肝炎病毒e1e2复合物的抗体，hcv颗粒的组合物和药物组合物公开(公告)号：US20070026003A1
公开(公告)日：2007-02-01
申请号：US10550295
申请日：2004-03-31
CPC分类号： C07K16/109 , A61K2039/505 , A61K2039/525 , A61K2039/5258 , C07K14/005 , C07K2317/21 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C12N7/00 , C12N2770/24222 , C12N2770/24223 , C12N2770/24251
摘要： New conformational antibodies are directed against HCV and more particularly to monoclonal antibodies. Described compositions of particles are liable to be recognized by the antibodies, as are pharmaceutical compositions containing them. Also described are HCV enveloped subviral particles or purified HCV enveloped complete viral particles, and the processes for preparing them.
摘要翻译： 新的构象抗体针对HCV，更具体地针对单克隆抗体。 颗粒的描述组合物易于被抗体识别，含有它们的药物组合物也是如此。 还描述了HCV包膜的亚病毒颗粒或纯化的HCV包膜的完整病毒颗粒，以及它们的制备方法。
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7.发明授权Antigens derived from filaggrin and their use for diagnosing rheumatoid polyarthritis 有权来源于丝聚蛋白的抗原及其用于诊断类风湿关节炎的用途公开(公告)号：US06890720B1
公开(公告)日：2005-05-10
申请号：US09254032
申请日：1997-09-01
申请人： Guy Serre , Elisabeth Girbal-Neuhauser , Christian Vincent , Michel Simon , Mireille Sebbag , Pascal Dalbon , Colette Jolivet-Reynaud , Michel Arnaud , Michel Jolivet
发明人： Guy Serre , Elisabeth Girbal-Neuhauser , Christian Vincent , Michel Simon , Mireille Sebbag , Pascal Dalbon , Colette Jolivet-Reynaud , Michel Arnaud , Michel Jolivet
CPC分类号： G01N33/564 , C07K14/4713
摘要： The invention concerns an artificial antigen specifically identified by the anti-filaggrin autoantibodies present in the serum of patients suffering from rheumatoid polyarthritis, and consisting of one polypeptide comprising all or part of the sequence of one filaggrin unit or of a related molecule, in which an arginine radical has been substituted by a citrulline radical. The invention also concerns the use of this antigen for diagnosing rheumatoid polyarthritis.
摘要翻译： 本发明涉及由存在于患有类风湿关节炎的患者的血清中的抗丝聚蛋白自身抗体特异性鉴定的人造抗原，并且由包含一个丝聚蛋白单元或相关分子的全部或部分序列的一种多肽组成，其中 精氨酸自由基被瓜氨酸碱基取代。 本发明还涉及该抗原用于诊断类风湿关节炎的用途。
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公开(公告)号：US6001987A
公开(公告)日：1999-12-14
申请号：US691563
申请日：1996-08-02
申请人： Herve Perron , Frederic Beseme , Frederic Bedin , Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Colette Jolivet-Reynaud , Bernard Mandrand
发明人： Herve Perron , Frederic Beseme , Frederic Bedin , Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Colette Jolivet-Reynaud , Bernard Mandrand
IPC分类号： G01N33/566 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/395 , A61K48/00 , A61P25/00 , A61P29/00 , A61P31/12 , A61P37/00 , C07K14/15 , C07K16/10 , C12N7/00 , C12N15/00 , C12N15/09 , C12N15/48 , C12Q1/04 , C12Q1/68 , C12R1/92 , C07H21/04 , A61K39/12 , A61K39/21
CPC分类号： C07K14/005 , C12Q1/6883 , C12Q1/702 , A61K2039/51 , A61K38/00 , A61K39/00 , C12N2740/10022
摘要： Viral material, in the isolated or purified state, in which the genome comprises a nucleotide sequence chosen from the group including sequences SEQ ID NO:46, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53 and SEQ ID NO:56, their complementary sequences and their equivalent sequences, in particular nucleotide sequences displaying, for any succession of 100 contiguous monomers, at least 50% and preferably at least 70% homology with the said sequences SEQ ID NO:46, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53 and SEQ ID NO:56, respectively, and their complementary sequences.
摘要翻译： 分离或纯化状态的病毒物质，其中基因组包含选自SEQ ID NO：46，SEQ ID NO：51，SEQ ID NO：52，SEQ ID NO：53和SEQ ID NO：53的核苷酸序列 SEQ ID NO：46，SEQ ID NO：56，其互补序列及其等同序列，特别是核苷酸序列，显示100个连续单体的任何连续序列，与所述序列SEQ ID NO：46，SEQ ID NO为至少50％，优选至少70％ ：51，SEQ ID NO：52，SEQ ID NO：53和SEQ ID NO：56及其互补序列。
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公开(公告)号：US5851535A
公开(公告)日：1998-12-22
申请号：US592646
申请日：1996-01-26
IPC分类号： A61K39/00 , C07K14/45 , C12N15/12 , A61K39/012
摘要： The invention relates to a polypeptide capable of reacting specifically with an anti-Toxoplasma gondii P30 protein antibody, and comprising a peptide sequence, in which any succession of 6 contiguous amino acids exhibits at most 67% homology with the peptide sequence of said P30 protein, identified by SEQ ID No.1, or comprising a sequence derived from said peptide sequence, and the applications of this polypeptide especially for detecting a Toxoplasma gondii infection, in a biological sample.
摘要翻译： 本发明涉及能够与抗弓形体弓形体P30蛋白抗体特异性反应的多肽，并且包含肽序列，其中任何连续的6个连续氨基酸与所述P30蛋白的肽序列具有最多67％的同源性， 由SEQ ID No.1鉴定，或包含源自所述肽序列的序列，以及该多肽的应用，特别是用于检测生物样品中的弓形虫感染。
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10.发明申请METHOD FOR DIRECT DETECTION OF ISCHEMIA-MODIFIED ALBUMIN USING A PARTNER FOR BINDING TO AN ALDEHYDE DERIVATIVE RESULTING FROM THE PEROXIDATION OF LIPIDS IN BOUND FORM 审中-公开使用合作伙伴直接检测异构体修饰的ALBUM的方法，用于结合来自于形式中脂肪过氧化物的ALDEHYDE DERIVATIVE公开(公告)号：US20110039353A1
公开(公告)日：2011-02-17
申请号：US12865562
申请日：2009-03-10
IPC分类号： G01N33/566 , G01N33/68 , C07K16/18
CPC分类号： G01N33/6893 , C07K16/18 , G01N2333/765 , G01N2800/324
摘要： The present invention relates to the use of at least one partner for binding to an aldehyde derivative resulting from the peroxidation of lipids in protein-bound form, for instance to 4-hydroxy-2-nonenal, to 4-hydroxy-2-hexenal or to malondialdehyde, for the detection of ischemia-modified albumin (IMA) in a biological sample.
摘要翻译： 本发明涉及至少一种配偶体与蛋白质结合形式的脂质例如4-羟基-2-壬烯醛过氧化成4-羟基-2-己烯醛的醛衍生物的结合的用途，或 用于丙二醛，用于检测生物样品中的缺血 - 修饰的白蛋白（IMA）。
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