摘要:
The invention concerns a polypeptide corresponding to amino acids 26 to 75 of the sequence of GRA5-RH protein of SEQ ID No 1: MASVKRVWAVMIVNVLALIFVGVAGSTRDVGSGGDDSEGARGRE QQQVQQHEQNEDRSLFERGRAAVT-GHPVRTAVGLAAAWAWSLL RLLKRRRRRAIQEESKESATAEEEEVAEEE, its variants acting on dendritic cell migration, homologues acting on dendritic cell migration, and fragments thereof acting on dendritic cell migration, as well as the pharmaceutical compositions thereof comprising such polypeptides and their use for making a medicine for preventing or treating skin and mucous membrane conditions involving dendritic cells or Langerhans cells.
摘要翻译:本发明涉及对应于SEQ ID No 1:MASVKRVWAVMIVNVLALIFVGVAGSTRDVGSGGDDSEGARGREQQQQQHEQNEDRSLFERGRAAVT-GHPVRTAVGLAAAWAWSLL RLLKRRRRRAIQEESKESATAEEEEVAEEE的GRA5-RH蛋白序列的氨基酸26至75的多肽,其作用于树突状细胞迁移的变体,作用于树突细胞迁移的同系物及其片段 作用于树突细胞迁移,以及其包含这些多肽的药物组合物及其用于制备用于预防或治疗涉及树突状细胞或朗格汉斯细胞的皮肤和粘膜病症的药物的用途。
摘要:
The invention relates to a digalactolipidic antigen exposed on the surface of apicomplex parasites, in the form of a vegetable-type digalactoglycerolipid, and adapted for inducing the production of specific antibodies capable of inhibiting the proliferation and/or the invasive properties of said parasites; the invention also relates to a derived antibody or functional antibody fragment, and to their diagnostic, immunotherapeutic and vaccine applications in human beings or animals.