Novel Polypeptides Inducing Dendritic Cell Migration, as Well as Medicines and Pharmaceutical Compositions Containing Same
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    发明申请
    Novel Polypeptides Inducing Dendritic Cell Migration, as Well as Medicines and Pharmaceutical Compositions Containing Same 审中-公开
    诱导树突状细胞迁移的新型多肽,以及含有其的药物和药物组合物

    公开(公告)号:US20100160219A1

    公开(公告)日:2010-06-24

    申请号:US12226744

    申请日:2007-04-27

    CPC分类号: C07K14/45

    摘要: The invention concerns a polypeptide corresponding to amino acids 26 to 75 of the sequence of GRA5-RH protein of SEQ ID No 1: MASVKRVWAVMIVNVLALIFVGVAGSTRDVGSGGDDSEGARGRE QQQVQQHEQNEDRSLFERGRAAVT-GHPVRTAVGLAAAWAWSLL RLLKRRRRRAIQEESKESATAEEEEVAEEE, its variants acting on dendritic cell migration, homologues acting on dendritic cell migration, and fragments thereof acting on dendritic cell migration, as well as the pharmaceutical compositions thereof comprising such polypeptides and their use for making a medicine for preventing or treating skin and mucous membrane conditions involving dendritic cells or Langerhans cells.

    摘要翻译: 本发明涉及对应于SEQ ID No 1:MASVKRVWAVMIVNVLALIFVGVAGSTRDVGSGGDDSEGARGREQQQQQHEQNEDRSLFERGRAAVT-GHPVRTAVGLAAAWAWSLL RLLKRRRRRAIQEESKESATAEEEEVAEEE的GRA5-RH蛋白序列的氨基酸26至75的多肽,其作用于树突状细胞迁移的变体,作用于树突细胞迁移的同系物及其片段 作用于树突细胞迁移,以及其包含这些多肽的药物组合物及其用于制备用于预防或治疗涉及树突状细胞或朗格汉斯细胞的皮肤和粘膜病症的药物的用途。