公开(公告)号：US06869783B1

公开(公告)日：2005-03-22

申请号：US09806876

申请日：1999-10-13

申请人： Marion Ress-Löschke ,  Thomas Friedrich ,  Bernhard Hauer ,  Ralf Mattes ,  Dirk Engels

发明人： Marion Ress-Löschke ,  Thomas Friedrich ,  Bernhard Hauer ,  Ralf Mattes ,  Dirk Engels

IPC分类号： C12N15/09 ,  C07H21/00 ,  C12N1/21 ,  C12N9/78 ,  C12N15/55 ,  C12P7/40 ,  C12P7/42 ,  C12P41/00 ,  C12R1/05 ,  C12P7/62

CPC分类号： C07H21/00 ,  C12N9/78 ,  C12P7/42 ,  C12P41/006

摘要： The invention relates to nucleic acid sequences which code for a polypeptide having nitrilase activity, to nucleic acid constructs comprising the nucleic acid sequences, and to vectors comprising the nucleic acid sequences or the nucleic acid constructs. The invention further relates to amino acid sequences which are encoded by the nucleic acid sequences, and to microorganisms comprising the nucleic acid sequences, the nucleic acid constructs or vectors comprising the nucleic acid sequences or the nucleic acid constructs.The invention additionally relates to a process for preparing chiral carboxylic acids from the racemic nitriles.

摘要翻译： 本发明涉及编码具有腈水解酶活性的多肽的核酸序列，包含核酸序列的核酸构建体以及包含核酸序列或核酸构建体的载体。 本发明还涉及由核酸序列编码的氨基酸序列，以及包含核酸序列，核酸构建体或包含核酸序列或核酸构建体的载体的微生物。本发明还涉及一种方法 用于从外消旋腈制备手性羧酸。