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1.发明授权Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer 失效用于鉴别，评估，预防和治疗乳腺癌的组合物，试剂盒和方法公开(公告)号：US07504222B2
公开(公告)日：2009-03-17
申请号：US10285393
申请日：2002-10-31
申请人： Mark D. Ayers , Jim Stec , Andrew Damokosh , Edwin Clark , Kenneth R. Hess , Gabriel N. Hortobagyi , Lajos Pusztai , W. Fraser Symmans , Robert C. Bast, Jr.
发明人： Mark D. Ayers , Jim Stec , Andrew Damokosh , Edwin Clark , Kenneth R. Hess , Gabriel N. Hortobagyi , Lajos Pusztai , W. Fraser Symmans , Robert C. Bast, Jr.
IPC分类号： G01N33/53
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158
摘要： The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers. A variety of newly identified markers are provided, wherein changes in the levels of expression of one or more of the markers is correlated with the presence of breast cancer.
摘要翻译： 本发明涉及用于检测，表征，预防和治疗人乳腺癌的组合物，试剂盒和方法。 提供了多种新鉴定的标记物，其中一种或多种标记物的表达水平的变化与乳腺癌的存在相关。
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2.发明申请Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer 审中-公开用于鉴别，评估，预防和治疗乳腺癌的组合物，试剂盒和方法公开(公告)号：US20100009358A1
公开(公告)日：2010-01-14
申请号：US12317078
申请日：2008-12-18
申请人： Mark D. Ayers , Jim Stec , Andrew Damokosh , Edwin Clark , Kenneth R. Hess , Gabriel N. Hortobagyi , Lajos Pusztai , W. Fraser Symmans , Robert C. Bast, JR.
发明人： Mark D. Ayers , Jim Stec , Andrew Damokosh , Edwin Clark , Kenneth R. Hess , Gabriel N. Hortobagyi , Lajos Pusztai , W. Fraser Symmans , Robert C. Bast, JR.
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158
摘要： The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers. A variety of newly identified markers are provided, wherein changes in the levels of expression of one or more of the markers is correlated with the presence of breast cancer.
摘要翻译： 本发明涉及用于检测，表征，预防和治疗人乳腺癌的组合物，试剂盒和方法。 提供了多种新鉴定的标记物，其中一种或多种标记物的表达水平的变化与乳腺癌的存在相关。
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3.发明申请INDEX OF GENOMIC EXPRESSION OF ESTROGEN RECEPTOR (ER) AND ER-RELATED GENES 审中-公开雌激素受体（ER）和ER相关基因的基因表达指数公开(公告)号：US20100311601A1
公开(公告)日：2010-12-09
申请号：US12772816
申请日：2010-05-03
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158 , G16B25/00
摘要： The present invention provides the identification and combination of genes that are expressed in tumors that are responsive to a given therapeutic agent and whose combined expression can be used as an index that correlates with responsiveness to that therapeutic agent. One or more of the genes of the present invention may be used as markers (or surrogate markers) to identify tumors that are likely to be successfully treated by that agent or class of agents such as hormonal or endocrine therapy or chemotherapy.
摘要翻译： 本发明提供了在对给定治疗剂有反应的肿瘤中表达的基因的鉴定和组合，并且其组合表达可用作与对该治疗剂的反应性相关的指标。 本发明的一个或多个基因可用作标志物（或替代标记物），以鉴定可能由该试剂或类别的试剂例如激素或内分泌治疗或化学疗法成功治疗的肿瘤。
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4.发明申请CALCULATED INDEX OF GENOMIC EXPRESSION OF ESTROGEN RECEPTOR (ER) AND ER-RELATED GENES 审中-公开雌激素受体（ER）和ER相关基因的基因表达的计算指数公开(公告)号：US20070134688A1
公开(公告)日：2007-06-14
申请号：US11530785
申请日：2006-09-11
IPC分类号： C12Q1/68 , G01N33/574 , A61K31/56
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N33/6842 , G01N33/743 , G01N2333/723 , G01N2800/52 , G16B20/00 , G16B25/00
摘要： The present invention provides the identification and combination of genes that are expressed in tumors that are responsive to a given therapeutic agent and whose combined expression can be used as an index that correlates with responsiveness to that therapeutic agent. One or more of the genes of the present invention may be used as markers (or surrogate markers) to identify tumors that are likely to be successfully treated by that agent or class of agents such as hormonal or endocrine treatment.
摘要翻译： 本发明提供了在对给定治疗剂有反应的肿瘤中表达的基因的鉴定和组合，并且其组合表达可用作与对该治疗剂的反应性相关的指标。 本发明的一个或多个基因可以用作标记物（或替代标记物），以鉴定可能被该试剂或一类试剂例如激素或内分泌治疗成功治疗的肿瘤。
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公开(公告)号：US07711494B2
公开(公告)日：2010-05-04
申请号：US11786980
申请日：2007-04-13
CPC分类号： G01N33/57484 , G01N33/574 , G01N33/57415
摘要： Disclosed is a method for determining survival and relapse of a patient undergoing therapy for a tumor by determining a residual cancer burden index based on the bidimensional diameters of a primary tumor bed of said tumor in a resection specimen, the proportion of the primary tumor bed area that contains invasive carcinoma, the number of regional lymph nodes containing metastatic carcinoma, the diameter of the largest metastasis in an regional lymph node; and the fractional reduction in lymph node size with each added positive lymph node.
摘要翻译： 公开了一种通过根据切除标本中所述肿瘤的原发肿瘤床的二维直径确定残留癌症负担指数来确定进行肿瘤治疗的患者的存活和复发的方法，原发性肿瘤床面积的比例 包括侵袭性癌，包含转移性癌的局部淋巴结数目，区域性淋巴结中最大转移的直径; 和淋巴结大小的分数减少每个添加阳性淋巴结。
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公开(公告)号：US20130084570A1
公开(公告)日：2013-04-04
申请号：US13641057
申请日：2011-04-14
申请人： Christos Hatzis , W. Fraser Symmans
发明人： Christos Hatzis , W. Fraser Symmans
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/68 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N33/57492 , G01N2333/91205 , G06F19/34 , G16B20/00 , G16B25/00 , G16B40/00 , H04L67/00
摘要： A method of evaluating a cancer patient comprising evaluating gene expression levels in a patient sample, calculating a predictor score using the gene expression levels, and assessing the likelihood of a therapeutic outcome using the predictor score is disclosed.
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