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    ENDOSCOPE HAVING 3D FUNCTIONALITY
    2.
    发明申请
    ENDOSCOPE HAVING 3D FUNCTIONALITY 审中-公开
    内窥镜具有3D功能

    公开(公告)号：US20140085421A1

    公开(公告)日：2014-03-27

    申请号：US13883319

    申请日：2011-08-23

    申请人： Rainer Kuth ,  Philip Mewes ,  Helmut Neumann ,  Markus Neurath ,  Anton Schick

    发明人： Rainer Kuth ,  Philip Mewes ,  Helmut Neumann ,  Markus Neurath ,  Anton Schick

    IPC分类号： A61B1/00

    CPC分类号： A61B1/00009 ,  A61B1/00193 ,  A61B1/018 ,  G01B11/12 ,  G01B11/25 ,  G02B23/2415 ,  G02B23/2484 ,  G02B23/26

    摘要： An endoscope for quantitatively determining dimensions of an object in a cavity is provided. The endoscope has a projector connected to a light guide that can be introduced through the instrument channel. In the introduced position the projector projects a pattern at a defined illumination angle onto the object to be examined. The endoscope has a camera that captures the projected pattern at a fixed viewing angle in a distorted from corresponding to the object. The distorted form is used for quantitatively determining dimensions of the object by a triangulation method.

    摘要翻译： 提供了一种用于定量地确定空腔中的物体的尺寸的内窥镜。 内窥镜具有连接到可以通过仪器通道引入的光导的投影仪。 在引入的位置，投影仪以确定的照明角度将图案投影到被检查物体上。 该内窥镜具有以与对象相对应的失真的固定视角拍摄投影图案的照相机。 扭曲形式用于通过三角测量方法定量地确定物体的尺寸。

    METHOD FOR PROCESSING AN ENDOSCOPY IMAGE
    4.
    发明申请
    METHOD FOR PROCESSING AN ENDOSCOPY IMAGE 审中-公开
    用于处理内窥镜图像的方法

    公开(公告)号：US20130079620A1

    公开(公告)日：2013-03-28

    申请号：US13577035

    申请日：2011-02-02

    申请人： Rainer Kuth ,  Markus Neurath

    发明人： Rainer Kuth ,  Markus Neurath

    IPC分类号： A61B1/04 ,  G06T7/00

    CPC分类号： A61B1/04 ,  G06T7/0012 ,  G06T7/90 ,  G06T2207/10024 ,  G06T2207/10068 ,  G06T2207/30092

    摘要： In a method for processing a generated digital endoscopy image of a patient, those pixels that depict a body region of a patient are determined as image points in the endoscopy image, in a processor. In the processor, a color value is derived for image point using the value of the associated pixel, and an area portion associated with each image point is derived for the color value. A color area is derived for each color value, as the sum of all area portions of the image points having that color value. An evaluation measure of the endoscopy image is then implemented in the processor using the respective color areas.

    摘要翻译： 在处理患者的生成的数字内窥镜检查图像的方法中，在处理器中将描绘患者身体区域的像素确定为内窥镜检查图像中的图像点。 在处理器中，使用相关像素的值导出用于图像点的颜色值，并且为颜色值导出与每个图像点相关联的区域部分。 导出每个颜色值的颜色区域，作为具有该颜色值的图像点的所有区域部分的总和。 然后在处理器中使用相应的颜色区域来实现内窥镜检查图像的评估测量。

    Methods of treating established colitis using antibodies against IL-12
    5.
    发明授权
    Methods of treating established colitis using antibodies against IL-12 失效
    使用抗IL-12抗体治疗既定结肠炎的方法

    公开(公告)号：US5853697A

    公开(公告)日：1998-12-29

    申请号：US547979

    申请日：1995-10-25

    申请人： Warren Strober ,  Ivan Fuss ,  Markus Neurath

    发明人： Warren Strober ,  Ivan Fuss ,  Markus Neurath

    IPC分类号： G01N33/53 ,  A61K31/00 ,  A61K38/00 ,  A61K39/395 ,  A61P1/00 ,  C07K16/24 ,  C12N15/09 ,  C12N15/24 ,  C12P21/08 ,  G01N33/15 ,  G01N33/543

    CPC分类号： C07K16/244 ,  A61K38/00 ,  Y10S436/811

    摘要： The present invention provides a method for treating the inflammatory response of an established colitis in a subject with inflammatory bowel disease (IBD), comprising administering to a subject diagnosed with an established colitis from an IBD an amount of an antibody to interleukin-12 effective in reducing the colitis-inducing effect of interleukin-12. Also provided is a method for screening a substance for its effectiveness in reducing the inflammatory response of an established colitis comprising obtaining an animal having an established colitis; administering the substance to an animal; and assaying the animal for an effect on interleukin-12 which results in the reduction of the inflammatory response of the colitis, an amount of reduction of the inflammatory response greater than the amount of reduction produced by the administration of antibodies against interferon-gamma or tumor necrosis factor-alpha indicating an effective substance. Additionally, the present invention provides a method for screening a substance for its effectiveness in preventing inflammatory bowel disease comprising administering the substance to an animal susceptible to colitis; subjecting the animal to a treatment that will induce a colitis; assaying the animal for the development of a colitis; and comparing the effectiveness of the substance in preventing development of a colitis to the effectiveness of antibodies to interferon-gamma or tumor necrosis factor-alpha in preventing development of a colitis, a substance more effective in preventing the development of a colitis than antibodies to interferon-gamma or tumor necrosis factor-alpha indicating an effective substance.

    摘要翻译： 本发明提供了一种用于治疗患有炎性肠病（IBD）的受试者中确定的结肠炎的炎症反应的方法，其包括向IBD诊断患有已确立的结肠炎的受试者施用有效白细胞介素-12抗体的量 降低白细胞介素-12的结肠炎诱导作用。 还提供了筛选物质以降低既定结肠炎的炎症反应的有效性的方法，包括获得具有既定结肠炎的动物; 将物质施用于动物; 并测定动物对白细胞介素-12的影响，其导致结肠炎的炎症反应的降低，炎症反应的减少量大于通过施用针对干扰素-γ或肿瘤的抗体产生的还原量 坏死因子-α表示有效物质。 另外，本发明提供了用于筛选物质以防止炎症性肠病的有效性的方法，其包括向易感染结肠炎的动物施用该物质; 对动物进行会引起结肠炎的治疗; 测定动物以发展结肠炎; 并比较该物质在预防结肠炎发展中的作用与抗体对干扰素-γ或肿瘤坏死因子-α在预防结肠炎发展中的有效性方面的有效性，这是比抗干扰素抗体更有效预防结肠炎发生的物质 γ或肿瘤坏死因子-α表示有效物质。