公开(公告)号：US08835579B2

公开(公告)日：2014-09-16

申请号：US13321889

申请日：2010-05-18

Applicant: Pascal Hayoz ,  Mathias Dueggeli ,  Martin Elbs ,  Olivier Frederic Aebischer ,  Achim Lamatsch

Inventor： Bernd Lamatsch ,  Pascal Hayoz ,  Mathias Dueggeli ,  Martin Elbs ,  Olivier Frederic Aebischer

IPC: C08F4/80 ,  C08F4/48 ,  C08F4/60

CPC classification number: C08G73/0672 ,  B01J31/2404 ,  B01J2231/4211 ,  B01J2531/824 ,  C08G61/124 ,  C08G61/126 ,  C08G2261/212 ,  C08G2261/312 ,  C08G2261/3223 ,  C08G2261/334 ,  C08G2261/364 ,  C08G2261/411 ,  C08G2261/5222 ,  C08G2261/91 ,  C08G2261/92 ,  C08G2261/94 ,  C09B57/004 ,  C09B69/109 ,  C09K11/06 ,  C09K2211/1458 ,  C09K2211/1466 ,  C09K2211/1475 ,  C09K2211/1483 ,  H01L51/0035 ,  H01L51/0036 ,  Y02E10/549 ,  Y02P70/521

Abstract: The present invention relates to a process for polymerizing (hetero)aromatic compounds under formation of aryl-aryl C—C couplings for preparing conjugated polymers with high molecular weight and high regioregularity, and to novel polymers obtainable by this process. The invention further relates to the use of the novel polymers as semiconductors or charge transport materials in optical, electrooptical or electronic devices including field effect transistors (FETs), thin film transistors (TFT), electroluminescent, photovoltaic and sensor devices.

Abstract translation: 本发明涉及用于制备具有高分子量和高定向度的共轭聚合物的芳基 - 芳基C-C偶联形成的（杂）芳族化合物的方法，以及可通过该方法获得的新型聚合物。 本发明还涉及新型聚合物作为半导体或电荷传输材料在包括场效应晶体管（FET），薄膜晶体管（TFT），电致发光，光电和传感器装置的光学，电光学或电子器件中的用途。

公开(公告)号：US20100184831A1

公开(公告)日：2010-07-22

申请号：US12227735

申请日：2007-05-30

Applicant: Stephen Lewis Hart ,  Stephanie Grosse ,  Alethea Bernice Tabor ,  John Bosco Wong ,  Martin Elbs ,  Helen Claire Hailes ,  Mohd Firouz Mohd Mustapa

Inventor： Stephen Lewis Hart ,  Stephanie Grosse ,  Alethea Bernice Tabor ,  John Bosco Wong ,  Martin Elbs ,  Helen Claire Hailes ,  Mohd Firouz Mohd Mustapa

IPC: A61K47/48 ,  C07K2/00 ,  C07C229/30 ,  A61P35/00

CPC classification number: A61K9/1271 ,  A61K9/0019 ,  A61K38/00 ,  A61K47/543 ,  A61K47/64 ,  A61K47/6455 ,  A61K47/65 ,  A61K47/6911 ,  A61K48/0008 ,  A61K48/0025 ,  A61K48/0041 ,  C07C217/28

Abstract: The invention provides a peptide derivative of formula A-B-C wherein A is a polycationic nucleic acid-binding component; B is a spacer element peptide that is susceptible to cleavage within a cell; and C is a cell surface receptor binding component. The invention also provides a lipid derivative of general formula (I): (PEG)q-Linker-Spacer-Cationic headgroup-carbon skeleton-(hydrophobic chain)o wherein: the Linker is a group susceptible to cleavage within a cell; the Spacer is a group linking the Linker to the Cationic headgroup; q denotes the number of PEG chains and q=1, 2 or 3; o denotes the number of hydrophobic chains and o=1, 2 or 3; the carbon skeleton is a group linking the hydrophobic chains to the cationic headgroup. The peptide and lipid derivatives find use in non-viral gene delivery systems.

Abstract translation: 本发明提供式A-B-C的肽衍生物，其中A是聚阳离子核酸结合组分; B是对细胞内切割敏感的间隔元件肽; C是细胞表面受体结合成分。 本发明还提供通式（I）的脂质衍生物：（PEG）q-连接子 - 间隔子阳离子头基 - 碳骨架 - （疏水链）o其中：连接子是细胞内易裂解的基团; Spacer是将Linker与阳离子头组联系起来的组; q表示PEG链的数目，q = 1,2或3; o表示疏水链的数目，o = 1,2或3; 碳骨架是将疏水链与阳离子头基连接的基团。 肽和脂质衍生物用于非病毒基因递送系统。

公开(公告)号：US20120142872A1

公开(公告)日：2012-06-07

申请号：US13321889

申请日：2010-05-18

Applicant: Bernd Lamatsch ,  Achim Lamatsch ,  Pascal Hayoz ,  Mathias Dueggeli ,  Martin Elbs ,  Olivier Frederic Aebischer

Inventor： Bernd Lamatsch ,  Achim Lamatsch ,  Pascal Hayoz ,  Mathias Dueggeli ,  Martin Elbs ,  Olivier Frederic Aebischer

IPC: C08F4/42 ,  C08G75/06

CPC classification number: C08G73/0672 ,  B01J31/2404 ,  B01J2231/4211 ,  B01J2531/824 ,  C08G61/124 ,  C08G61/126 ,  C08G2261/212 ,  C08G2261/312 ,  C08G2261/3223 ,  C08G2261/334 ,  C08G2261/364 ,  C08G2261/411 ,  C08G2261/5222 ,  C08G2261/91 ,  C08G2261/92 ,  C08G2261/94 ,  C09B57/004 ,  C09B69/109 ,  C09K11/06 ,  C09K2211/1458 ,  C09K2211/1466 ,  C09K2211/1475 ,  C09K2211/1483 ,  H01L51/0035 ,  H01L51/0036 ,  Y02E10/549 ,  Y02P70/521

Abstract: The present invention relates to a process for polymerising (hetero)aromatic compounds under formation of aryl-aryl C—C couplings for preparing conjugated polymers with high molecular weight and high regioregularity, and to novel polymers obtainable by this process. The invention further relates to the use of the novel polymers as semiconductors or charge transport materials in optical, electrooptical or electronic devices including field effect transistors (FETs), thin film transistors (TFT), electroluminescent, photovoltaic and sensor devices.

Abstract translation: 本发明涉及用于制备具有高分子量和高定向度的共轭聚合物的芳基 - 芳基C-C偶联形成聚合（杂）芳族化合物的方法，以及可通过该方法获得的新型聚合物。 本发明还涉及新型聚合物作为半导体或电荷传输材料在包括场效应晶体管（FET），薄膜晶体管（TFT），电致发光，光电和传感器装置的光学，电光学或电子器件中的用途。

公开(公告)号：US09399016B2

公开(公告)日：2016-07-26

申请号：US12227735

申请日：2007-05-30

Applicant: Stephen Lewis Hart ,  Stephanie Grosse ,  Alethea Bernice Tabor ,  John Bosco Wong ,  Martin Elbs ,  Helen Claire Hailes ,  Mohd Firouz Mohd Mustapa

Inventor： Stephen Lewis Hart ,  Stephanie Grosse ,  Alethea Bernice Tabor ,  John Bosco Wong ,  Martin Elbs ,  Helen Claire Hailes ,  Mohd Firouz Mohd Mustapa

IPC: A61K47/48 ,  A61P35/00 ,  C07C229/30 ,  C07K2/00 ,  A61K9/127 ,  A61K9/00 ,  A61K48/00 ,  C07C217/28 ,  A61K38/00

CPC classification number: A61K9/1271 ,  A61K9/0019 ,  A61K38/00 ,  A61K47/543 ,  A61K47/64 ,  A61K47/6455 ,  A61K47/65 ,  A61K47/6911 ,  A61K48/0008 ,  A61K48/0025 ,  A61K48/0041 ,  C07C217/28

Abstract: The invention provides a peptide derivative of formula A-B-C wherein A is a polycationic nucleic acid-binding component; B is a spacer element peptide that is susceptible to cleavage within a cell; and C is a cell surface receptor binding component. The invention also provides a lipid derivative of general formula (I): (PEG)q-Linker-Spacer-Cationic headgroup-carbon skeleton-(hydrophobic chain)o wherein: the Linker is a group susceptible to cleavage within a cell; the Spacer is a group linking the Linker to the Cationic headgroup; q denotes the number of PEG chains and q=1, 2 or 3; o denotes the number of hydrophobic chains and o=1, 2 or 3; the carbon skeleton is a group linking the hydrophobic chains to the cationic headgroup. The peptide and lipid derivatives find use in non-viral gene delivery systems.

Abstract translation: 本发明提供式A-B-C的肽衍生物，其中A是聚阳离子核酸结合组分; B是对细胞内切割敏感的间隔元件肽; C是细胞表面受体结合成分。 本发明还提供通式（I）的脂质衍生物：（PEG）q-连接子 - 间隔子阳离子头基 - 碳骨架 - （疏水链）o其中：连接子是细胞内易裂解的基团; Spacer是将Linker与阳离子头组联系起来的组; q表示PEG链的数目，q = 1,2或3; o表示疏水链的数目，o = 1,2或3; 碳骨架是将疏水链与阳离子头基连接的基团。 肽和脂质衍生物用于非病毒基因递送系统。

公开(公告)号：US09074050B2

公开(公告)日：2015-07-07

申请号：US14122873

申请日：2012-05-29

Applicant: Matthias Kleiner ,  Martin Elbs ,  Marcel Kastler

Inventor： Matthias Kleiner ,  Martin Elbs ,  Marcel Kastler

IPC: C08F28/06 ,  C08G73/00 ,  C08G75/06 ,  C08G61/12 ,  B01J19/08 ,  B01J19/12 ,  B01J19/18 ,  B01J19/24 ,  B01J19/28

CPC classification number: C08G75/06 ,  B01J19/082 ,  B01J19/123 ,  B01J19/1818 ,  B01J19/1831 ,  B01J19/1856 ,  B01J19/1862 ,  B01J19/242 ,  B01J19/243 ,  B01J19/2445 ,  B01J19/245 ,  B01J19/285 ,  B01J2219/00202 ,  C08G61/124 ,  C08G61/126 ,  C08G2261/124 ,  C08G2261/3223 ,  C08G2261/344 ,  C08G2261/411

Abstract: The present invention relates to a continuous process for the production of polymeric coupling products by using a reactor assembly which is equipped with two or more reaction cells. The educt fluid is pumped through the reaction cells and thoroughly mixed therein by means of agitators. Preferably the process according to the invention is used for the preparation of coupling products which show at least partially precipitation and/or gelation effects during the performance of the synthesis. The precipitation and/or gelation effects are associated with and increase of the viscosity of the reaction system under reaction conditions. The products which are obtained by the process according to the invention have increased molecular weight and low polydispersity over similar products which were obtained in batch experiments.

Abstract translation: 本发明涉及通过使用装备有两个或更多个反应池的反应器组件来生产聚合物偶联产物的连续方法。 将喷射流体泵送通过反应池并通过搅拌器充分混合。 优选地，根据本发明的方法用于制备在合成过程中显示至少部分沉淀和/或凝胶化作用的偶联产物。 在反应条件下，沉淀和/或凝胶化作用与反应体系的粘度相关并增加。 通过本发明方法获得的产物与分批实验中获得的相似产品相比，分子量增加和分散性降低。

公开(公告)号：US20140080994A1

公开(公告)日：2014-03-20

申请号：US14122873

申请日：2012-05-29

Applicant: Matthias Kleiner ,  Martin Elbs ,  Marcel Kastler

Inventor： Matthias Kleiner ,  Martin Elbs ,  Marcel Kastler

IPC: C08G75/06

CPC classification number: C08G75/06 ,  B01J19/082 ,  B01J19/123 ,  B01J19/1818 ,  B01J19/1831 ,  B01J19/1856 ,  B01J19/1862 ,  B01J19/242 ,  B01J19/243 ,  B01J19/2445 ,  B01J19/245 ,  B01J19/285 ,  B01J2219/00202 ,  C08G61/124 ,  C08G61/126 ,  C08G2261/124 ,  C08G2261/3223 ,  C08G2261/344 ,  C08G2261/411

Abstract: The present invention relates to a continuous process for the production of polymeric coupling products by using a reactor assembly which is equipped with two or more reaction cells. The educt fluid is pumped through the reaction cells and thoroughly mixed therein by means of agitators. Preferably the process according to the invention is used for the preparation of coupling products which show at least partially precipitation and/or gelation effects during the performance of the synthesis. The precipitation and/or gelation effects are associated with and increase of the viscosity of the reaction system under reaction conditions. The products which are obtained by the process according to the invention have increased molecular weight and low polydispersity over similar products which were obtained in batch experiments.

Abstract translation: 本发明涉及通过使用装备有两个或更多个反应池的反应器组件来生产聚合物偶联产物的连续方法。 将喷射流体泵送通过反应池并通过搅拌器充分混合。 优选地，根据本发明的方法用于制备在合成过程中显示至少部分沉淀和/或凝胶化作用的偶联产物。 在反应条件下，沉淀和/或凝胶化作用与反应体系的粘度相关并增加。 通过本发明方法获得的产物与分批实验中获得的相似产品相比，分子量增加和分散性降低。