SOLID PHASE GOLD NANOPARTICLE SYNTHESIS
    8.
    发明申请
    SOLID PHASE GOLD NANOPARTICLE SYNTHESIS 有权
    固相金纳米晶合成

    公开(公告)号:US20120130053A1

    公开(公告)日:2012-05-24

    申请号:US13109438

    申请日:2011-05-17

    Abstract: A method of synthesizing ligand-conjugated gold nanoparticles (AuNPs) is disclosed. The method comprises: a) providing an amine-modified silica particle; b) providing a solution comprising Au+3 ions; c) suspending the amine-modified silica particle in the solution comprising Au+3 ions; d) allowing the Au3+ ions to be adsorbed and/or immobilized onto the surface of the amine-modified silica particle; e) exposing the Au3+ ions immobilized onto the surface of the amine-modified silica particle to radiation to obtain bare gold nanoparticles (AuNPs) adsorbed and/or immobilized onto the surface of the amine-modified silica particle, wherein the bare AuNPs are without organic surface modifications; and f) reacting a ligand with the bare AuNPs adsorbed and/or immobilized onto the surface of the amine-modified SiNP and thereby obtain ligand-conjugated gold nanoparticles (AuNPs).

    Abstract translation: 公开了一种合成配体结合金纳米粒子(AuNPs)的方法。 该方法包括:a)提供胺改性的二氧化硅颗粒; b)提供包含Au + 3离子的溶液; c)将胺改性的二氧化硅颗粒悬浮在包含Au + 3离子的溶液中; d)允许Au 3+离子被吸附和/或固定在胺改性二氧化硅颗粒的表面上; e)将固定在胺改性的二氧化硅颗粒的表面上的Au 3+离子暴露于辐射以获得吸附和/或固定在胺改性的二氧化硅颗粒的表面上的裸金纳米颗粒(AuNP),其中裸露的AuNP是无机的 表面修饰 和f)将配体与吸附和/或固定在胺修饰的SiNP的表面上的裸AuNP反应,从而获得配体缀合的金纳米颗粒(AuNP)。

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