公开(公告)号：US20090124512A1

公开(公告)日：2009-05-14

申请号：US12160784

申请日：2007-01-18

Applicant: Kathy L. Rowlen ,  Robert Kuchta ,  Michael Townsend ,  James Smagala ,  Chad L. Moore ,  Erica Dawson ,  Martin Mehlmann ,  Nancy Cox ,  Catherine B. Smith ,  Daniela Mehlmann

Inventor： Kathy L. Rowlen ,  Robert Kuchta ,  Michael Townsend ,  James Smagala ,  Chad L. Moore ,  Erica Dawson ,  Martin Mehlmann ,  Nancy Cox ,  Catherine B. Smith ,  Daniela Mehlmann

IPC: C40B40/06 ,  C40B50/00 ,  C40B30/04

CPC classification number: C12Q1/701 ,  C12Q2565/501

Abstract: Embodiments herein provide for methods, compositions and apparati for detection and/or diagnosis of virus types, subtypes and/or strains. In particular embodiments, the virus is an influenza virus. The apparatus may include a microarray with attached capture probes, designed to bind to oligonucleotides capable of binding at least a portion of a nucleic acid sequence of one or more target genes in a broad array of influenza types, subtypes or strains. The compositions may include isolated nucleic acids as capture probes, target sequences and/or tagged label probes, of use for diagnosis and/or detection of influenza virus.

Abstract translation: 本文的实施方案提供了用于病毒类型，亚型和/或毒株的检测和/或诊断的方法，组合物和装置。 在具体实施方案中，病毒是流感病毒。 该装置可以包括具有连接的捕获探针的微阵列，设计成与能够结合广泛的流感类型，亚型或毒株的一个或多个目标基因的核酸序列的至少一部分的寡核苷酸结合。 组合物可以包括用于诊断和/或检测流感病毒的分离的核酸作为捕获探针，靶序列和/或标记的标记探针。

公开(公告)号：US20100130378A1

公开(公告)日：2010-05-27

申请号：US12522146

申请日：2008-01-03

Applicant: Kathy L. Rowlen ,  Daniela M. Mehlmann ,  Robert Kuchta ,  Martin Mehlmann ,  James Smagala ,  Chad Moore ,  Erica Dawson-Tenet ,  Nancy Cox ,  Michael W. Shaw

Inventor： Kathy L. Rowlen ,  Daniela M. Mehlmann ,  Robert Kuchta ,  Martin Mehlmann ,  James Smagala ,  Chad Moore ,  Erica Dawson-Tenet ,  Nancy Cox ,  Michael W. Shaw

IPC: C40B30/04 ,  C40B40/06 ,  C40B50/14

CPC classification number: C12Q1/701

Abstract: Embodiments herein provide for methods, compositions and apparatus for detection and/or diagnosis of pathogenic virus lineage and/or strains. In some embodiments, the virus is influenza Type B virus. In other embodiments, an apparatus may include a microarray with attached capture probes, designed to bind to nucleic acid sequences from a single gene in a broad array of influenza strains. In some embodiments, compositions may include isolated nucleic acid sequences of use as capture probes, target sequences and/or label probe sequences, for diagnosis of and/or detection of influenza virus.

Abstract translation: 本文的实施方案提供了用于检测和/或诊断致病性病毒谱系和/或菌株的方法，组合物和装置。 在一些实施方案中，病毒是B型流感病毒。 在其他实施方案中，装置可以包括具有连接的捕获探针的微阵列，其被设计为结合来自广泛流感病毒株中的单个基因的核酸序列。 在一些实施方案中，组合物可以包括用作诊断和/或检测流感病毒的分离的核酸序列，其用作捕获探针，靶序列和/或标记探针序列。