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    DETECTION OF ANTIVIRAL RESISTANCE IN INFLUENZA A USING DNA MICROARRAY
    3.
    发明申请
    DETECTION OF ANTIVIRAL RESISTANCE IN INFLUENZA A USING DNA MICROARRAY 审中-公开
    检测使用DNA微阵列的流感病毒抗性

    公开(公告)号：US20100273670A1

    公开(公告)日：2010-10-28

    申请号：US12438271

    申请日：2007-08-21

    申请人： Kathy L. Rowlen ,  Robert Kuchta ,  Michael Townsend ,  James Smagala ,  Erica Dawson

    发明人： Kathy L. Rowlen ,  Robert Kuchta ,  Michael Townsend ,  James Smagala ,  Erica Dawson

    IPC分类号： C40B30/04 ,  C40B40/06 ,  C40B50/14

    CPC分类号： C12Q1/70

    摘要： Embodiments of the present invention relate to compositions, methods and apparatus for detection of antiviral agent resistance or sensitivity of a virus. In some embodiments, antiviral agent resistance or sensitivity of influenza types, such as A, B and C may be identified. In more embodiments, sub-types such as the hemagglutinin (HA) and neuraminidase (NA) of influenza A may be analyzed for antiviral agent resistance or sensitivity. In a particular embodiment, the various strains of influenza virus may be analyzed for resistance or sensitivity using DNA microarray analysis designed to target a gene segment. In various embodiments, a microarray-based assay system with capture and detection (label) probes may be utilized to identify a change in a gene segment that confers resistance or sensitivity to an antiviral agent of an influenza strain.

    摘要翻译： 本发明的实施方案涉及用于检测抗病毒剂抗性或病毒敏感性的组合物，方法和装置。 在一些实施方案中，可以鉴定抗病毒剂抗性或流感类型如A，B和C的敏感性。 在更多实施方案中，可以分析甲型流感病毒的血细胞凝集素（HA）和神经氨酸酶（NA）等亚类的抗病毒药物抗性或敏感性。 在一个具体实施方案中，可以使用设计用于靶向基因片段的DNA微阵列分析来分析各种流感病毒株的抗性或敏感性。 在各种实施方案中，具有捕获和检测（标记）探针的基于微阵列的测定系统可用于鉴定赋予对流感病毒株抗病毒药物的抗性或敏感性的基因区段的变化。

    Use of photopolymerization for amplification and detection of a molecular recognition event
    4.
    发明授权
    Use of photopolymerization for amplification and detection of a molecular recognition event 失效
    使用光聚合进行扩增和检测分子识别事件

    公开(公告)号：US07354706B2

    公开(公告)日：2008-04-08

    申请号：US11372485

    申请日：2006-03-09

    申请人： Kathy L. Rowlen ,  John W. Birks ,  Christopher Bowman ,  Hadley Sikes ,  Ryan Hansen ,  Robert Kuchta

    发明人： Kathy L. Rowlen ,  John W. Birks ,  Christopher Bowman ,  Hadley Sikes ,  Ryan Hansen ,  Robert Kuchta

    IPC分类号： C12Q1/68 ,  C12Q1/70 ,  G01N33/53

    CPC分类号： C12Q1/6816 ,  C12Q2565/401

    摘要： The invention provides methods to detect molecular recognition events. The invention also provides methods to detect the presence of or identify a target species based on its interaction with one or more probe species. The methods of the invention are based on amplification of the signal due to each molecular recognition event. The amplification is achieved through photopolymerization, with the polymer formed being associated with the molecular recognition event. In an embodiment, a fluorescent polymer, a magnetic polymer, a radioactive polymer or an electrically conducting polymer can form the basis of detection and amplification. In another embodiment, a polymer gel swollen with a fluorescent solution, a magnetic solution, a radioactive solution or an electrically conducting solution can form the basis of detection and amplification. In another embodiment, sufficient polymer forms to be detectable by visual inspection.

    摘要翻译： 本发明提供检测分子识别事件的方法。 本发明还提供了基于其与一种或多种探针物种的相互作用来检测靶物种的存在或鉴定目的物种的方法。 本发明的方法基于由于每个分子识别事件引起的信号的放大。 通过光聚合实现扩增，形成的聚合物与分子识别事件相关联。 在一个实施方案中，荧光聚合物，磁性聚合物，放射性聚合物或导电聚合物可以形成检测和扩增的基础。 在另一个实施方案中，用荧光溶液，磁性溶液，放射性溶液或导电溶液溶胀的聚合物凝胶可以形成检测和扩增的基础。 在另一个实施方案中，足够的聚合物形式可通过目视检查来检测。

    Use of photopolymerization for amplification and detection of a molecular recognition event
    5.
    发明申请
    Use of photopolymerization for amplification and detection of a molecular recognition event 失效
    使用光聚合扩增和检测分子识别事件

    公开(公告)号：US20060286570A1

    公开(公告)日：2006-12-21

    申请号：US11372485

    申请日：2006-03-09

    申请人： Kathy Rowlen ,  John Birks ,  Christopher Bowman ,  Hadley Sikes ,  Ryan Hansen ,  Robert Kuchta

    发明人： Kathy Rowlen ,  John Birks ,  Christopher Bowman ,  Hadley Sikes ,  Ryan Hansen ,  Robert Kuchta

    IPC分类号： C12Q1/70 ,  C12Q1/68

    CPC分类号： C12Q1/6816 ,  C12Q2565/401

    摘要： The invention provides methods to detect molecular recognition events. The invention also provides methods to detect the presence of or identify a target species based on its interaction with one or more probe species. The methods of the invention are based on amplification of the signal due to each molecular recognition event. The amplification is achieved through photopolymerization, with the polymer formed being associated with the molecular recognition event. In an embodiment, a fluorescent polymer, a magnetic polymer, a radioactive polymer or an electrically conducting polymer can form the basis of detection and amplification. In another embodiment, a polymer gel swollen with a fluorescent solution, a magnetic solution, a radioactive solution or an electrically conducting solution can form the basis of detection and amplification. In another embodiment, sufficient polymer forms to be detectable by visual inspection.

    摘要翻译： 本发明提供检测分子识别事件的方法。 本发明还提供了基于其与一种或多种探针物种的相互作用来检测靶物种的存在或鉴定目的物种的方法。 本发明的方法基于由于每个分子识别事件引起的信号的放大。 通过光聚合实现扩增，形成的聚合物与分子识别事件相关联。 在一个实施方案中，荧光聚合物，磁性聚合物，放射性聚合物或导电聚合物可以形成检测和扩增的基础。 在另一个实施方案中，用荧光溶液，磁性溶液，放射性溶液或导电溶液溶胀的聚合物凝胶可以形成检测和扩增的基础。 在另一个实施方案中，足够的聚合物形式可通过目视检查来检测。