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    TWO-PIECE INJECTABLE DRUG DELIVERY DEVICE WITH HEAT-CURED SEAL
    1.
    发明申请
    TWO-PIECE INJECTABLE DRUG DELIVERY DEVICE WITH HEAT-CURED SEAL 审中-公开
    具有热固封口的双层可注射药物递送装置

    公开(公告)号：US20120238993A1

    公开(公告)日：2012-09-20

    申请号：US13333731

    申请日：2011-12-21

    Applicant: Martin Nazzaro ,  Josh York ,  Paul Ashton

    Inventor： Martin Nazzaro ,  Josh York ,  Paul Ashton

    IPC: A61M5/00 ,  B23P17/04

    CPC classification number: A61L27/34 ,  A61K9/0051 ,  A61K9/0092 ,  A61K31/5575 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/61 ,  Y10T29/49826 ,  C08L67/04 ,  C08L29/04

    Abstract: The invention provides a drug delivery device for one or more drugs. The device has a drug core which is surrounded by an internal and external sheath. The external sheath has a first cap that is permeable to at least one drug in the core. The first cap may comprise polyvinyl alcohol (PVA), and the PVA may be heat cured. In certain aspects, there are one or more additional caps on the ends of the sheaths formed from one or more polymers. In certain aspects, one or more portions of the drug delivery device are substantially impermeable to one or more drugs in the drug core. In certain aspects, the drug elutes through the first cap into a biological environment. The invention further provides methods for manufacturing the drug delivery device.

    Abstract translation: 本发明提供了一种或多种药物的药物递送装置。 该装置具有由内部和外部护套包围的药物核心。 外部护套具有对芯中的至少一种药物可渗透的第一帽。 第一盖可以包括聚乙烯醇（PVA），并且PVA可以被热固化。 在某些方面，在由一种或多种聚合物形成的护套的端部上存在一个或多个另外的帽。 在某些方面，药物递送装置的一个或多个部分对药物核心中的一种或多种药物是基本上不可渗透的。 在某些方面，药物通过第一帽洗脱成生物环境。 本发明还提供了用于制造药物递送装置的方法。

    Injector apparatus and method of use
    2.
    发明申请
    Injector apparatus and method of use 有权
    注射装置及使用方法

    公开(公告)号：US20080071246A1

    公开(公告)日：2008-03-20

    申请号：US11900907

    申请日：2007-09-12

    Applicant: Martin Nazzaro ,  Hong Guo ,  Ron LeBlanc ,  Josh York

    Inventor： Martin Nazzaro ,  Hong Guo ,  Ron LeBlanc ,  Josh York

    IPC: A61M5/178

    CPC classification number: A61F9/0017 ,  A61M5/329 ,  A61M5/46 ,  A61M31/007 ,  A61M37/0069 ,  A61M2005/31508

    Abstract: Disclosed herein is an injector device including an inserter element, a head element, an implant and a set of detachable protector elements for secured device handling. The device comprises a stop that controls the penetration depth of the device during injection. The device may comprise a removable catch that prevents the implant from exiting the device due to the advancement of its inserter element. The device may comprise a disengageable block that prevents the implant from exiting the device from its head element. The device may be configured for intraocular drug delivery.

    Abstract translation: 本文公开了一种注射器装置，其包括插入元件，头元件，植入物和用于安全装置处理的一组可拆卸保护器元件。 该装置包括在注射期间控制装置的穿透深度的止挡件。 该装置可以包括可移除的捕获物，其防止植入物由于其插入元件的推进而离开装置。 该装置可以包括防止植入物从其头部元件离开装置的可脱离块。 该装置可以被配置用于眼内药物递送。

    Injector apparatus and method of use
    3.
    发明授权
    Injector apparatus and method of use 有权
    注射装置及使用方法

    公开(公告)号：US07998108B2

    公开(公告)日：2011-08-16

    申请号：US11900907

    申请日：2007-09-12

    Applicant: Martin Nazzaro ,  Hong Guo ,  Ron LeBlanc ,  Josh York

    Inventor： Martin Nazzaro ,  Hong Guo ,  Ron LeBlanc ,  Josh York

    IPC: A61M31/00

    CPC classification number: A61F9/0017 ,  A61M5/329 ,  A61M5/46 ,  A61M31/007 ,  A61M37/0069 ,  A61M2005/31508

    Abstract: Disclosed herein is an injector device including an inserter element, a head element, an implant and a set of detachable protector elements for secured device handling. The device comprises a stop that controls the penetration depth of the device during injection. The device may comprise a removable catch that prevents the implant from exiting the device due to the advancement of its inserter element. The device may comprise a disengageable block that prevents the implant from exiting the device from its head element. The device may be configured for intraocular drug delivery.

    Abstract translation: 本文公开了一种注射器装置，其包括插入元件，头元件，植入物和用于安全装置处理的一组可拆卸保护器元件。 该装置包括在注射期间控制装置的穿透深度的止挡件。 该装置可以包括可移除的捕获物，其防止植入物由于其插入元件的推进而离开装置。 该装置可以包括防止植入物从其头部元件离开装置的可脱离块。 该装置可以被配置用于眼内药物递送。

    TWO-PIECE INJECTABLE DRUG DELIVERY DEVICE WITH HEAT-CURED SEAL
    6.
    发明申请
    TWO-PIECE INJECTABLE DRUG DELIVERY DEVICE WITH HEAT-CURED SEAL 审中-公开
    具有热固封口的双层可注射药物递送装置

    公开(公告)号：US20120238994A1

    公开(公告)日：2012-09-20

    申请号：US13333743

    申请日：2011-12-21

    Applicant: Martin Nazzaro ,  Josh York ,  Paul Ashton

    Inventor： Martin Nazzaro ,  Josh York ,  Paul Ashton

    IPC: A61M5/00 ,  B23P17/04

    CPC classification number: A61L27/34 ,  A61K9/0051 ,  A61K9/0092 ,  A61K31/5575 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/61 ,  Y10T29/49826 ,  C08L67/04 ,  C08L29/04

    Abstract: The invention provides a drug delivery device for latanoprost or latanoprost acid. The device has a core of latanoprost or latanoprost acid which is surrounded by an internal and external sheath. The external sheath has a first cap that is permeable to latanoprost or latanoprost acid. The first cap may comprise polyvinyl alcohol (PVA), and the PVA may be heat cured. In certain aspects, there are one or more additional caps on the ends of the sheaths formed from one or more polymers. In certain aspects, one or more portions of the drug delivery device is substantially impermeable to latanoprost or latanoprost acid. In certain aspects, the latanoprost or latanoprost acid elutes through the first cap into a biological environment. The invention further provides methods for manufacturing the drug delivery device.

    Abstract translation: 本发明提供了拉坦前列素或拉坦前列素酸的药物递送装置。 该装置具有由内部和外部护套包围的拉坦前列素或拉坦前列素酸的核心。 外鞘具有对拉坦前列素或拉坦前列素酸可渗透的第一帽。 第一盖可以包括聚乙烯醇（PVA），并且PVA可以被热固化。 在某些方面，在由一种或多种聚合物形成的护套的端部上存在一个或多个另外的帽。 在某些方面，药物递送装置的一个或多个部分对于拉坦前列素或拉坦前列素酸是基本上不可渗透的。 在某些方面，拉坦前列素或拉坦前列素酸通过第一帽洗脱成生物环境。 本发明还提供了用于制造药物递送装置的方法。

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