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    Pharmaceutical compositions
    1.
    发明授权
    Pharmaceutical compositions 失效
    药物组合物

    公开(公告)号：US5476867A

    公开(公告)日：1995-12-19

    申请号：US290752

    申请日：1994-08-15

    申请人： Edward A. Boyd ,  Brenda Costall ,  Mary E. Kelly ,  Philip J. Parsons

    发明人： Edward A. Boyd ,  Brenda Costall ,  Mary E. Kelly ,  Philip J. Parsons

    IPC分类号： A61K31/42 ,  A61K31/423 ,  A61P25/20 ,  A61P25/22 ,  A61P25/28 ,  C07D261/20 ,  C07D413/04

    CPC分类号： C07D413/04 ,  C07D261/20

    摘要： Compounds of formula (I) ##STR1## in which R.sub.1 represents hydrogen, a C.sub.1-6 aliphatic hydrocarbyl group or a C.sub.1-4 aliphatic hydrocarbyl group substituted by a C.sub.3-6 alicyclic hydrocarbyl group or by a phenyl group, which phenyl group is unsubstituted or substituted by a halogeno or C.sub.1-3 halogenoalkyl group, R.sub.2 represents hydrogen, R.sub.3 represents hydrogen, a 5- or 6-membered ring aromatic heterocyclyl group containing one or two heteroatoms selected from nitrogen, oxygen and sulphur which is unsubstituted or substituted by a halogeno or C.sub.1-3 halogenoalkyl group, or a group AR wherein A is a straight chain C.sub.1-4 aliphatic hydrocarbyl group terminally substituted by R which is hydrogen, a phenyl group or a 5- or 6-membered ring aromatic heterocyclyl group containing one or two heteroatoms selected from nitrogen, oxygen and sulphur, which phenyl or heterocyclyl group R is unsubstituted or substituted by a halogeno or C.sub.1-3 halogenoalkyl group, R.sub.4 and R.sub.5 each represent hydrogen or together represent an oxo group and R.sub.6, R.sub.7 and R.sub.8 each represent hydrogen, or R.sub.4 represents hydrogen and two of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 together represent the second bond of a double bond joining positions 4 and 5, 5 and 6 or 6 and 7 with the remaining two of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 representing hydrogen, the compound optionally being in the form of a salt thereof formed with a physiologically acceptable inorganic or organic acid, are of value for the treatment of anxiety and in the improvement of learning and/or the reversal of amnesia.

    摘要翻译： 式（I）化合物其中R 1表示氢，C 1-6脂族烃基或C 3-6脂族烃基被C 3-6脂环族烃基或苯基取代的式（I）化合物，该苯基 基团是未取代的或被卤素或C 1-3卤代烷基取代，R 2表示氢，R 3表示氢，含有一个或两个选自氮，氧和硫的杂原子的5-或6-元环芳族杂环基，其是未取代的或 被卤素或C 1-3卤代烷基取代的基团，其中A是由R末端取代的直链C 1-4脂族烃基，其中R是氢，苯基或5-或6-元环芳族杂环基 含有一个或两个选自氮，氧和硫的杂原子，该苯基或杂环基R是未取代的或被卤代或C 1-3卤代烷基取代，R 4和R 5各自代表氢或一起代表 R 6，R 7和R 8各自表示氢，或R 4表示氢，R 5，R 6，R 7和R 8中的两个表示双键连接位置4和5，5和6或6和7的第二个键 剩余的R5，R6，R7和R8中的两个代表氢，任选呈其生理学上可接受的无机或有机酸形成的盐的化合物对于治疗焦虑和改善学习是有价值的 和/或逆转遗忘。

    Pharmaceutical compositions
    3.
    发明授权
    Pharmaceutical compositions 失效
    药物组合物

    公开(公告)号：US5578626A

    公开(公告)日：1996-11-26

    申请号：US478142

    申请日：1995-06-07

    申请人： Edward A. Boyd ,  Brenda Costall ,  Mary E. Kelly ,  Philip J. Parsons

    发明人： Edward A. Boyd ,  Brenda Costall ,  Mary E. Kelly ,  Philip J. Parsons

    IPC分类号： A61K31/42 ,  A61K31/423 ,  A61P25/20 ,  A61P25/22 ,  A61P25/28 ,  C07D261/20 ,  C07D413/04

    CPC分类号： C07D413/04 ,  C07D261/20

    摘要： Compounds of formula (I) ##STR1## in which R.sub.1 represents hydrogen, a C.sub.1-6 aliphatic hydrocarbyl group or a C.sub.1-4 aliphatic hydrocarbyl group substituted by a C.sub.3-6 alicyclic hydrocarbyl group or by a phenyl group, which phenyl group is unsubstituted or substituted by a halogeno or C.sub.1-3 halogenoalkyl group, R.sub.2 represents hydrogen, R.sub.3 represents hydrogen, a 5-or 6-membered ring aromatic heterocyclyl group containing one or two heteroatoms selected from nitrogen, oxygen and sulphur which is unsubstituted or substituted by a halogeno or C.sub.1-3 halogenoalkyl group, or a group AR wherein A is a straight chain C.sub.1-4 aliphatic hydrocarbyl group terminally substituted by R which is hydrogen, a phenyl group or a 5-or 6-membered ring aromatic heterocyclyl group containing one or two heteroatoms selected from nitrogen, oxygen and sulphur, which phenyl or heterocyclyl group R is unsubstituted or substituted by a halogeno or C.sub.1-3 halogenoalkyl group, R.sub.4 and R.sub.5 each represent hydrogen or together represent an oxo group and R.sub.6, R.sub.7 and R.sub.8 each represent hydrogen, or R.sub.4 represents hydrogen and two of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 together represent the second bond of a double bond joining positions 4 and 5, 5 and 6 or 6 and 7 with the remaining two of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 representing hydrogen, the compound optionally being in the form of a salt thereof formed with a physiologically acceptable inorganic or organic acid, are of value for the treatment of anxiety and in the improvement of learning ability and/or the reversal of amnesia.

    摘要翻译： 式（I）化合物其中R 1表示氢，C 1-6脂族烃基或C 3-6脂族烃基被C 3-6脂环族烃基或苯基取代的式（I）化合物，该苯基 基团是未取代的或被卤代或C 1-3卤代烷基取代，R 2表示氢，R 3表示氢，含有一个或两个选自氮，氧和硫的杂原子的5-或6-元环芳族杂环基，其是未取代的或 被卤素或C 1-3卤代烷基取代的基团，其中A是由R末端取代的直链C 1-4脂族烃基，其中R是氢，苯基或5-或6-元环芳族杂环基 含有一个或两个选自氮，氧和硫的杂原子，该苯基或杂环基R未被取代或被卤代或C 1-3卤代烷基取代，R 4和R 5各自表示氢或一起代表 发送氧代基，R6，R7和R8各自表示氢，或R4表示氢，R5，R6，R7和R8中的两个表示双键连接位置4和5，6和6和7的第二个键 剩余的R5，R6，R7和R8中的两个代表氢，任选呈其生理学上可接受的无机或有机酸形成的盐的化合物对于治疗焦虑和改善学习是有价值的 能力和/或逆转遗忘。

    Lesson-based virtual reality welding training system
    4.
    发明授权
    Lesson-based virtual reality welding training system 有权

    公开(公告)号：US11783727B1

    公开(公告)日：2023-10-10

    申请号：US17859604

    申请日：2022-07-07

    申请人： Mary E. Kelly ,  Christopher Schuler

    发明人： Mary E. Kelly ,  Christopher Schuler

    IPC分类号： G09B19/24 ,  G09B9/00 ,  G06F3/01 ,  G06F3/0482

    CPC分类号： G09B19/24 ,  G06F3/011 ,  G06F3/016 ,  G09B9/00 ,  G06F3/0482

    摘要： Systems and methods for lesson-based virtual reality (VR) welding training are provided. Broadly, the system creates a configurable, three-dimensional, virtual reality training environment displayed on a VR display. Using a handheld controller associated with the VR display, a student may select a welding lesson. The welding lessons correspond to a variety of different settings, such as welding process type, workpiece type, workpiece position, finishing tool type, guidance mode, and welding machine settings. The student then creates a weld on the workpiece via the handheld controller, and the system provides real-time feedback, such as audio, visual, and/or haptic, to the student. Once the student has completed the weld, the system generates and displays an assessment of the weld.

    Vesiculated polymer beads
    5.
    发明授权
    Vesiculated polymer beads 失效
    泡沫聚合物珠粒

    公开(公告)号：US5470887A

    公开(公告)日：1995-11-28

    申请号：US232643

    申请日：1994-04-25

    申请人： Neil Perrins ,  Mary E. Kelly

    发明人： Neil Perrins ,  Mary E. Kelly

    IPC分类号： C08F283/01 ,  C08J9/28 ,  C08F8/00

    CPC分类号： C08J9/28 ,  C08F283/01 ,  C08J2351/00

    摘要： Vesiculated polymer beads are prepared in which a water-in-oil-in-water emulsion containing a cross-linkable polymer and a copolymerizable monomer in the oil phase is heated in the presence of an initiator to cure the polymer beads, wherein curing is commenced in a first stage in the presence of a substantially water-insoluble initiator and, when the beads are sufficiently stable, curing is completed in a second stage in the presence of an at least partially water-soluble initiator. Preferably, the completion of curing is carried out at a temperature higher than that of the first stage. The beads can be used in low odor paint formulations.

    摘要翻译： 制备泡沫聚合物珠，其中在引发剂存在下加热包含油相中的可交联聚合物和可共聚单体的水包油包水乳液以固化聚合物珠，其中固化开始 在基本上不溶于水的引发剂的存在下的第一阶段，当珠粒足够稳定时，在至少部分水溶性引发剂的存在下，在第二阶段中完成固化。 优选地，固化完成在高于第一阶段的温度下进行。 珠可用于低气味涂料配方中。