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1.发明授权Antibodies that bind novel carbohydrate ligands (myelorollins) that cause E-selectin dependent cell rolling, and uses thereof 失效结合导致E-选择素依赖性细胞翻滚的新型碳水化合物配体（髓磷脂）的抗体及其用途
公开(公告)号：US5876715A
公开(公告)日：1999-03-02
申请号：US635849
申请日：1996-04-22
IPC分类号： A61P29/00 , C07H3/06 , C07H15/10 , A61K39/395 , C07K16/00
摘要： The invention relates to antibodies that specifically bind a myelorollin comprising an unbranched polylactosamine comprising at least 10 monosaccharides and having terminal .alpha.2.fwdarw.3 sialylation and internal .alpha.1.fwdarw.3 fucosylation at various N-acetylglucosamine residues except the penultimate N-acetylglucosamine residue. The invention also relates to a method of using such antibodies to inhibit E-selectin-dependent rolling of a cell on another cell, wherein one of the cells expresses a myelorollin that binds the antibodies.
摘要翻译： 本发明涉及特异性结合髓鞘蛋白的抗体，其包含非分支的多聚乳糖胺，其包含至少10个单糖并且具有末端α2-> 3唾液酸化和内部α1→3岩藻糖基化，除了倒数第二个N-乙酰氨基葡萄糖残基之外的各种N-乙酰葡糖胺残基。 本发明还涉及使用这种抗体抑制细胞在另一个细胞上的E-选择蛋白依赖性滚动的方法，其中一个细胞表达结合抗体的髓鞘蛋白。
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2.发明授权Carbohydrate ligands (myelorollin) that cause E-selectin dependent cell rolling and adhesion under dynamic flow system 失效在动态流动系统下引起E-选择素依赖性细胞滚动和粘附的碳水化合物配体（髓磷脂）
公开(公告)号：US6133239A
公开(公告)日：2000-10-17
申请号：US688124
申请日：1996-07-29
摘要： An unbranched polylactosamine comprising at least 6 monosaccharides and having terminal .alpha.2.fwdarw.3 sialylation and internal .alpha.1.fwdarw.3 fucosylation at various N-acetylglucosamine residues except for solely at the penultimate N-acetylglucosamine residue.
摘要翻译： 包含至少6个单糖并且具有末端α2-> 3唾液酸化和不同N-乙酰葡糖胺残基的内部α1-> 3岩藻糖基化的非支化多聚乳糖胺，除了仅在倒数第二个N-乙酰氨基葡萄糖残基之外。
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3.发明授权Naturally occurring gangliosides containing de-N-acetyl-sialic acid and their applications as modifiers of cell physiology 失效含有脱-N-乙酰唾液酸的天然存在的神经节苷脂及其作为细胞生理学改性剂的应用
公开(公告)号：US5272138A
公开(公告)日：1993-12-21
申请号：US467458
申请日：1990-01-19
申请人： Sen-itiroh Hakomori , Gustavo A. Nores , Nobuo Hanai , Taeko Dohi , Steven B. Levery , Mary Ellen K. Salyan , Hisao Nojiri
发明人： Sen-itiroh Hakomori , Gustavo A. Nores , Nobuo Hanai , Taeko Dohi , Steven B. Levery , Mary Ellen K. Salyan , Hisao Nojiri
IPC分类号： A61K31/70 , C07H15/10 , A61K31/725 , C07H5/06 , C07H13/06
摘要： A method for preparing de-N-acylated forms of an N-acyl sugar-containing glycosphingolipid and lyso forms of glycosphingolipid comprising hydrolyzing the glycosphingolipids under mild alkaline conditions such that the N-acyl group of the sugar moiety is preferentially hydrolyzed. Substantially pure gangliosides containing de-N-acetyl-sialic acid isolated from natural sources. A culture medium for stimulating growth of human and animal cells comprising: essential nutrients for cell growth, and a cell growth stimulatory amount of one or more gangliosides containing de-N-acetyl-sialic acid. A method for stimulating growth of human and animal cells cultured in vitro with a cell growth stimulatory amount of one or more gangliosides containing de-N-acetyl-sialic acid. A medicament and method for stimulating or inhibiting growth of human and animal cells by stimulating or inhibiting the production of growth stimulators selected from the group consisting of gangliosides containing de-N-acetyl-sialic acid, substances that promote synthesis of gangliosides containing de-N-acetyl-sialic acid and pharmaceutically acceptable salts thereof.
摘要翻译： 一种制备N-酰基糖型鞘糖脂的N-脱酰基形式的方法，其包括在温和碱性条件下水解糖鞘脂，使糖部分的N-酰基优先水解。 含有从天然来源分离的脱-N-乙酰唾液酸的纯粹神经节苷脂。 用于刺激人和动物细胞生长的培养基包括：用于细胞生长的必需营养物和含有脱-N-乙酰唾液酸的一种或多种神经节苷脂的细胞生长刺激量。 用于刺激体外培养的细胞生长刺激量的含有脱-N-乙酰唾液酸的一种或多种神经节苷脂的人和动物细胞生长的方法。 通过刺激或抑制选自包含脱-N-乙酰唾液酸的神经节苷脂的生长刺激剂的生成来刺激或抑制人和动物细胞生长的药物和方法，促进含有脱-N-乙酰唾液酸的神经节苷脂合成的物质 乙酰唾液酸及其药学上可接受的盐。
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