公开(公告)号：US20100133445A1

公开(公告)日：2010-06-03

申请号：US12600540

申请日：2008-05-20

申请人： Akira Noda ,  Toshiyuki Shirai ,  Masahiro Ikegami ,  Shu Nakamura ,  Hiroyuki Daido ,  Kouji Noda

发明人： Akira Noda ,  Toshiyuki Shirai ,  Masahiro Ikegami ,  Shu Nakamura ,  Hiroyuki Daido ,  Kouji Noda

IPC分类号： H01J3/08 ,  H01J27/00 ,  H01J3/12 ,  H01J3/14

CPC分类号： G21K1/087 ,  A61N2005/1087 ,  A61N2005/1088 ,  H05H7/12

摘要： Provided are an ion beam control apparatus and a control method for controlling an ion beam energy expansion level and an ion beam size in a radial direction. An ion beam control apparatus Sa is provided with an ion beam generating unit 2, and an ion beam control unit 1a in which a generated ion beam (IB) is input and controlled to be output with the prescribed level of energy expansion and the prescribed diameter in the radial direction. In the ion beam control unit 1a, phase rotation by a radio frequency electric field that increases existing probability with the prescribed level of energy is at least used.

摘要翻译： 提供了一种用于控制离子束能量膨胀水平和离子束尺寸在径向方向上的离子束控制装置和控制方法。 离子束控制装置Sa设置有离子束产生单元2和离子束控制单元1a，其中生成的离子束（IB）被输入并被控制为以规定的能量膨胀水平和规定的直径输出 在径向方向。 在离子束控制单元1a中，至少使用通过以规定的能量水平增加现有概率的射频电场的相位旋转。

公开(公告)号：US20130080072A1

公开(公告)日：2013-03-28

申请号：US13565565

申请日：2012-08-02

申请人： Masahiro Ikegami

发明人： Masahiro Ikegami

IPC分类号： G06F19/00 ,  H01J49/26

CPC分类号： G06K9/00134 ,  G06F19/24 ,  H01J49/0004

摘要： Specific-site extraction unit 24 extracts specific sites from microscopy images that are obtained by staining or fluorescence labeling of specific sites in a specimen 4, Based on the similarity between MS imaging data and the spatial distribution of the specific sites, cluster analysis unit 25 and division count determination processing unit 26 evaluate the similarity with the spatial distribution of all pixels that belong to one cluster when each of the pixels are categorized into a plurality of clusters. Since the specific sites are sites that include the same characteristic substance, clustering is judged to be appropriate if the similarity in spatial distribution is high. Hence, based on the correlation between spatial distributions, an appropriate division count for the cluster analysis is determined, and the result of the cluster analysis using the division count is output on a display unit 31.

摘要翻译： 特异性提取单元24从样本中的特定位点的染色或荧光标记获得的显微镜图像中提取特定位点。基于MS成像数据与特定位点的空间分布之间的相似性，聚类分析单元25和 分割计数确定处理单元26当将每个像素分类为多个聚类时，评估属于一个群集的所有像素的空间分布的相似度。 由于特定地点是包含相同特征物质的地点，因此如果空间分布的相似性较高，则认为聚类是合适的。 因此，基于空间分布之间的相关性，确定用于聚类分析的合适的分割计数，并且使用分割计数的聚类分析的结果在显示单元31上输出。

公开(公告)号：US08498989B2

公开(公告)日：2013-07-30

申请号：US13396478

申请日：2012-02-14

申请人： Masahiro Ikegami

发明人： Masahiro Ikegami

IPC分类号： G06F17/30

CPC分类号： H03M7/3059 ,  H01J49/0004 ,  H01J49/0036

摘要： Provided is a method for quickly obtaining an intensity value at a desired m/z value in a compressed data obtained by run-length encoding of a mass analysis data. An index is created by pairing either the start position of a section where zero-intensity consecutively occurs two or more times in an array of an original spectrum data, or the start position of a sequence of data having significant intensity values in an array of the original spectrum data, with the corresponding position in an array of a compressed data. This index is stored separate from the compressed data. The creation of the index does not affect the array of the compressed data. Therefore, the data can be decompressed even by a data processing system that does not use the index. The index helps to quickly locate a compressed data corresponding to the desired m/z and obtain the necessary intensity value.

摘要翻译： 提供了一种在通过质量分析数据的游程长度编码获得的压缩数据中快速获得期望m / z值的强度值的方法。 索引是通过将原始频谱数据的阵列中的零强度连续发生两次或更多次的部分的开始位置，或者在原始频谱数据的阵列中的具有显着强度值的数据序列的开始位置 原始频谱数据，其中相应的位置在压缩数据的阵列中。 该索引与压缩数据分开存储。 索引的创建不会影响压缩数据的数组。 因此，即使不使用索引的数据处理系统也可以解压缩数据。 该索引有助于快速定位对应于所需m / z的压缩数据，并获得必要的强度值。

公开(公告)号：US20120209854A1

公开(公告)日：2012-08-16

申请号：US13396478

申请日：2012-02-14

申请人： Masahiro IKEGAMI

发明人： Masahiro IKEGAMI

IPC分类号： G06F17/30

CPC分类号： H03M7/3059 ,  H01J49/0004 ,  H01J49/0036

摘要： Provided is a method for quickly obtaining an intensity value at a desired m/z value in a compressed data obtained by run-length encoding of a mass analysis data. An index is created by pairing either the start position of a section where zero-intensity consecutively occurs two or more times in an array of an original spectrum data, or the start position of a sequence of data having significant intensity values in an array of the original spectrum data, with the corresponding position in an array of a compressed data. This index is stored separate from the compressed data. The creation of the index does not affect the array of the compressed data. Therefore, the data can be decompressed even by a data processing system that does not use the index. The index helps to quickly locate a compressed data corresponding to the desired m/z and obtain the necessary intensity value.

摘要翻译： 提供了一种在通过质量分析数据的游程长度编码获得的压缩数据中快速获得期望m / z值的强度值的方法。 索引是通过将原始频谱数据的阵列中的零强度连续发生两次或更多次的部分的开始位置，或者在原始频谱数据的阵列中的具有显着强度值的数据序列的开始位置 原始频谱数据，其中相应的位置在压缩数据的阵列中。 该索引与压缩数据分开存储。 索引的创建不会影响压缩数据的数组。 因此，即使不使用索引的数据处理系统也可以解压缩数据。 该索引有助于快速定位对应于所需m / z的压缩数据，并获得必要的强度值。

公开(公告)号：US20110228970A1

公开(公告)日：2011-09-22

申请号：US13048729

申请日：2011-03-15

申请人： Shigeki KAJIHARA ,  Masahiro IKEGAMI ,  Hiroko MORINAGA

发明人： Shigeki KAJIHARA ,  Masahiro IKEGAMI ,  Hiroko MORINAGA

IPC分类号： G06K9/00

CPC分类号： H01J49/0004 ,  H01J49/0036

摘要： The present invention provides a method and apparatus for efficiently handling a large amount of data collected by an imaging mass analysis to present significant information for the analysis of the tissue structure of a biological sample or other objects in an intuitively understandable form for analysis operators. For each pixel 8b on a sample 8, a mass-to-charge ratio m/z(i) corresponding to the maximum intensity MI(i) in a mass spectrum is listed, and the largest value MII of the maximum intensities of all the pixels are extracted. A color scale corresponding to the intensity values within a range of 0 to MII is defined. For each pixel, the maximum intensity MI is compared with the color scale to assign a color to that pixel. A mapping image with the pixels shown in the respective colors is created and displayed. Simultaneously, a spectrum showing the relationship between MI(i) and m/z(i) of all the pixels is created in such a manner that the peak colors correspond to the pixel colors on the mapping image. The mapping image shows the tissue structure of the sample. By comparing this image with the spectrum, the m/z of a noticeable substance in the sample can be identified.

摘要翻译： 本发明提供了一种用于有效地处理通过成像质量分析收集的大量数据的方法和装置，以便以分析操作者的直观可理解的形式呈现用于分析生物样品或其他物体的组织结构的重要信息。 对于样品8上的每个像素8b，列出了与质谱中的最大强度MI（i）相对应的质荷比m / z（i），并且所有的最大强度的最大值MII 提取像素。 定义与0〜MII的范围内的强度值对应的色标。 对于每个像素，将最大强度MI与颜色比例进行比较，以向该像素分配颜色。 创建并显示具有各颜色所示的像素的映射图像。 同时，产生表示所有像素的MI（i）和m / z（i）之间的关系的光谱，使得峰值对应于映射图像上的像素颜色。 映射图显示样品的组织结构。 通过将该图像与光谱进行比较，可以确定样品中明显物质的m / z。

公开(公告)号：US20100127183A1

公开(公告)日：2010-05-27

申请号：US12509116

申请日：2009-07-24

申请人： Yasushi ISEKI ,  Takeshi Yoshiyuki ,  Hiroyuki Daido ,  Masahiro Ikegami ,  Mamiko Nishiuchi ,  Akira Noda

发明人： Yasushi ISEKI ,  Takeshi Yoshiyuki ,  Hiroyuki Daido ,  Masahiro Ikegami ,  Mamiko Nishiuchi ,  Akira Noda

IPC分类号： H01J1/50 ,  H01J3/14

CPC分类号： A61N5/1043 ,  A61N2005/1087 ,  A61N2005/1088

摘要： A laser-driven particle beam irradiation apparatus includes: a particle beam generator irradiating a target with pulsed laser light to emit a laser-driven particle ray; a beam converging unit forming a transportation path which guides the emitted laser-driven particle ray to an object and spatially converging the laser-driven particle ray; an energy selector selecting an energy and an energy width of the laser-driven particle ray; an irradiation port causing the laser-driven particle ray to scan the object to adjust an irradiation position in the object; and an irradiation controller controlling operation of the particle beam generator, the beam converging unit, the energy selector and the irradiation port. The beam converging unit generates a magnetic field on a trajectory of the laser-driven particle ray and converging the laser-driven particle ray by the magnetic field, the magnetic field forcing divergence components of the laser-driven particle ray that go away from a center of the trajectory back to the center of the trajectory.

摘要翻译： 激光驱动的粒子束照射装置包括：粒子束发生器，用脉冲激光照射靶，发射激光驱动的粒子射线; 光束会聚单元，其形成将发射的激光驱动的粒子射线引导到物体并将激光驱动的粒子射线空间收敛的输送路径; 选择激光驱动粒子射线的能量和能量的能量选择器; 照射端口，使激光驱动的粒子射线扫描物体以调节物体中的照射位置; 以及照射控制器，其控制粒子束发生器，束会聚单元，能量选择器和照射端口的操作。 光束会聚单元在激光驱动的粒子射线的轨迹上产生磁场并通过磁场会聚激光驱动的粒子射线，迫使离开中心的激光驱动的粒子射线的发散分量的磁场强迫 的轨迹回到轨迹的中心。

公开(公告)号：US6035844A

公开(公告)日：2000-03-14

申请号：US936730

申请日：1997-09-25

申请人： Ryuji Otani ,  Isao Fuwa ,  Masahiro Ikegami ,  Noboru Kusano ,  Toshikazu Hamada ,  Kyoichiro Nakayama

发明人： Ryuji Otani ,  Isao Fuwa ,  Masahiro Ikegami ,  Noboru Kusano ,  Toshikazu Hamada ,  Kyoichiro Nakayama

IPC分类号： B23D61/04 ,  B23D65/00 ,  B23K15/00 ,  B23K26/00 ,  B23K26/20 ,  B23P15/28 ,  B28D1/12

CPC分类号： B23D61/04 ,  B23P15/28 ,  Y10T83/9319 ,  Y10T83/9367

摘要： A cutting tool is provided which includes a steel metal body and a cemented carbide cutting tip secured to the metal body by a metallic layer. The metallic layer has a high-strength metallic portion and a high-toughness metallic portion. The high-strength metallic portion is made of a metal having a thermal expansion rate between a thermal expansion rate of the metal body and the thermal expansion rate of the cutting tip. The high-toughness metallic portion is located between edge portions of a securing region of the metal body and the cutting tip and has toughness larger than that of the high-strength metallic portion. The cutting tool can decrease the possibility of cracks being generated at the edge portions of the securing region by selecting a thermal expansion rate of the metallic layer so as to decrease the thermal stress caused during the cooling process after welding, and further by positioning a high-toughness metallic layer at the edge portions of the securing region where stress is concentrated and positioning a high-strength metallic layer meeting the strength requirement at the remaining portion of the securing region.

摘要翻译： 提供了一种切削工具，其包括钢金属体和通过金属层固定到金属体的硬质合金切削刀头。 金属层具有高强度金属部分和高韧性金属部分。 高强度金属部由具有金属体的热膨胀率与切削刃的热膨胀率之间的热膨胀率的金属制成。 高韧性金属部分位于金属体的固定区域和切割尖端的边缘部分之间，其韧性大于高强度金属部分的韧性。 切削工具可以通过选择金属层的热膨胀率来减少在固定区域的边缘部分产生裂纹的可能性，从而降低在焊接之后的冷却过程中产生的热应力，并且进一步通过定位高 在紧固应力集中的固定区域的边缘部分设置柔性金属层，并且在固定区域的其余部分定位满足强度要求的高强度金属层。

公开(公告)号：US09589174B2

公开(公告)日：2017-03-07

申请号：US13565565

申请日：2012-08-02

申请人： Masahiro Ikegami

发明人： Masahiro Ikegami

IPC分类号： H01J49/26 ,  G06K9/00 ,  G06F19/24 ,  H01J49/00

CPC分类号： G06K9/00134 ,  G06F19/24 ,  H01J49/0004

摘要： Specific-site extraction unit 24 extracts specific sites from microscopy images that are obtained by staining or fluorescence labeling of specific sites in a specimen 4. Based on the similarity between MS imaging data and the spatial distribution of the specific sites, cluster analysis unit 25 and division count determination processing unit 26 evaluate the similarity with the spatial distribution of all pixels that belong to one cluster when each of the pixels are categorized into a plurality of clusters. Since the specific sites are sites that include the same characteristic substance, clustering is judged to be appropriate if the similarity in spatial distribution is high. Hence, based on the correlation between spatial distributions, an appropriate division count for the cluster analysis is determined, and the result of the cluster analysis using the division count is output on a display unit 31.

摘要翻译： 特异性位点提取单元24从通过对样本4中的特定位点的染色或荧光标记获得的显微镜图像提取特定位点。基于MS成像数据与特定位点的空间分布之间的相似性，聚类分析单元25和 分割计数确定处理单元26当将每个像素分类为多个聚类时，评估属于一个群集的所有像素的空间分布的相似度。 由于特定地点是包含相同特征物质的地点，因此如果空间分布的相似性较高，则认为聚类是合适的。 因此，基于空间分布之间的相关性，确定用于聚类分析的合适的分割计数，并且使用分割计数的聚类分析的结果在显示单元31上输出。

公开(公告)号：US09536716B2

公开(公告)日：2017-01-03

申请号：US13029040

申请日：2011-02-16

申请人： Masahiro Ikegami ,  Takahiro Harada

发明人： Masahiro Ikegami ,  Takahiro Harada

IPC分类号： H01J49/00

CPC分类号： H01J49/0004 ,  H01J49/0009

摘要： When a sample plate 3 is set on a sample stage 2, an irradiation trace formation controller 22 appropriately moves the sample stage 2 and throws a short pulse of high-power laser beam to create an irradiation trace at a predetermined position on the sample plate 3. The irradiation trace has a unique shape. A microscopic image of the irradiation trace is captured and saved in an image storage section 32. After the sample plate 3 is temporarily removed from the stage 2 to apply a matrix to a sample, the sample plate 3 is re-set on the same stage 2. Then, the displacement of the sample plate 3 from its original position is calculated from the difference in the position of the irradiation trace between an image taken at that point in time and the image previously stored in the image storage section 32. Based on the calculated result, an analysis position corrector 24 modifies the position information of an area selected by an operator. Thus, the displacement of the re-set sample plate can be accurately detected. There is no need to use a special sample plate previously processed for creating a marker for displacement detection.

摘要翻译： 当样品板3设置在样品台2上时，照射迹线形成控制器22适当地移动样品台2并投射短脉冲的大功率激光束以在样品板3上的预定位置产生照射迹线 照射迹线具有独特的形状。 照射迹线的显微镜图像被捕获并保存在图像存储部分32中。在将样品板3从阶段2暂时移除以将样品施加到样品上之后，将样品板3重新设置在相同的台 然后，根据在该时间点拍摄的图像与先前存储在图像存储部32中的图像之间的照射迹线的位置的差异来计算样品板3从其原始位置的位移。基于 计算结果，分析位置校正器24修改由操作者选择的区域的位置信息。 因此，可以精确地检测重新设定的样品板的位移。 不需要使用先前处理过的用于创建位移检测标记的特殊样品板。

公开(公告)号：US08222617B2

公开(公告)日：2012-07-17

申请号：US12509116

申请日：2009-07-24

申请人： Yasushi Iseki ,  Takeshi Yoshiyuki ,  Hiroyuki Daido ,  Masahiro Ikegami ,  Mamiko Nishiuchi ,  Akira Noda

发明人： Yasushi Iseki ,  Takeshi Yoshiyuki ,  Hiroyuki Daido ,  Masahiro Ikegami ,  Mamiko Nishiuchi ,  Akira Noda

IPC分类号： G21G5/00

CPC分类号： A61N5/1043 ,  A61N2005/1087 ,  A61N2005/1088

摘要： A laser-driven particle beam irradiation apparatus includes: a particle beam generator irradiating a target with pulsed laser light to emit a laser-driven particle ray; a beam converging unit forming a transportation path which guides the emitted laser-driven particle ray to an object and spatially converging the laser-driven particle ray; an energy selector selecting an energy and an energy width of the laser-driven particle ray; an irradiation port causing the laser-driven particle ray to scan the object to adjust an irradiation position in the object; and an irradiation controller controlling operation of the particle beam generator, the beam converging unit, the energy selector and the irradiation port. The beam converging unit generates a magnetic field on a trajectory of the laser-driven particle ray and converging the laser-driven particle ray by the magnetic field, the magnetic field forcing divergence components of the laser-driven particle ray that go away from a center of the trajectory back to the center of the trajectory.

摘要翻译： 激光驱动的粒子束照射装置包括：粒子束发生器，用脉冲激光照射靶，发射激光驱动的粒子射线; 光束会聚单元，其形成将发射的激光驱动的粒子射线引导到物体并将激光驱动的粒子射线空间收敛的输送路径; 选择激光驱动粒子射线的能量和能量的能量选择器; 照射端口，使激光驱动的粒子射线扫描物体以调节物体中的照射位置; 以及照射控制器，其控制粒子束发生器，束会聚单元，能量选择器和照射端口的操作。 光束会聚单元在激光驱动的粒子射线的轨迹上产生磁场并通过磁场会聚激光驱动的粒子射线，迫使离开中心的激光驱动的粒子射线的发散分量的磁场强迫 的轨迹回到轨迹的中心。