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    Transdermal preparation
    1.
    发明授权
    Transdermal preparation 有权

    公开(公告)号：US08475835B2

    公开(公告)日：2013-07-02

    申请号：US13318370

    申请日：2010-04-30

    Applicant: Satoshi Amano ,  Tomohiro Shinoda ,  Natsumi Kase

    Inventor： Satoshi Amano ,  Tomohiro Shinoda ,  Natsumi Kase

    IPC: A61K9/70

    Abstract: Provided is a transdermal preparation, which is capable of long-term (1-day to 7-day) release of a basic drug from a preparation, continuously and at a consistent concentration; shows little reduction over time in the drug content, even if multiple drugs are contained in the preparation; and is produced by a simple process. The transdermal preparation comprises a substrate, and an adhesive layer containing a basic drug and a water-soluble polymer.

    Method For Growing Fibroblasts
    2.
    发明申请
    Method For Growing Fibroblasts 有权
    生长成纤维细胞的方法

    公开(公告)号：US20120328648A1

    公开(公告)日：2012-12-27

    申请号：US13593683

    申请日：2012-08-24

    Applicant: Masato IINO ,  Satoshi AMANO

    Inventor： Masato IINO ,  Satoshi AMANO

    IPC: A61K8/99 ,  A61Q19/08

    CPC classification number: A61Q19/08 ,  A61K8/97 ,  A61K8/99

    Abstract: A method for reducing the occurrence of wrinkles in skin caused by aging by promoting the growth of fibroblasts, which have a declined cellular proliferative potential due to aging or adverse affects from ultraviolet light or active oxygen. The method includes the steps of providing an agent that contains a yeast extract and a safflower extract as effective constituents, and applying the agent to skin to promote the growth of fibroblasts.

    Abstract translation: 通过促进由于老化引起的细胞增殖潜力下降的成纤维细胞的生长或紫外线或活性氧的不利影响，减少老化引起的皮肤皱纹的发生的方法。 该方法包括以下步骤：提供含有酵母提取物和红花提取物作为有效成分的试剂，并将该试剂施用于皮肤以促进成纤维细胞的生长。

    Wrinkling Prevention or Remedy with Adam Activity Inhibiting Substance
    3.
    发明申请
    Wrinkling Prevention or Remedy with Adam Activity Inhibiting Substance 审中-公开
    亚当活动抑制物质起皱预防或治疗

    公开(公告)号：US20080319084A1

    公开(公告)日：2008-12-25

    申请号：US11665213

    申请日：2005-10-13

    Applicant: Yukiko Matsunaga ,  Satoshi Amano ,  Yuki Ogura

    Inventor： Yukiko Matsunaga ,  Satoshi Amano ,  Yuki Ogura

    IPC: A61K31/166 ,  C12Q1/02 ,  A61Q19/00 ,  C12Q1/68

    CPC classification number: A61Q19/08 ,  A61K8/42 ,  A61K8/442 ,  A61K2800/782

    Abstract: A composition contains a substance, which is capable of inhibiting activity of ADAM (a disintegrin and metalloprotease) present in a skin, in a proportion efficient for preventing or remedying wrinkling. Wrinkling is prevented or remedied with a method comprising the step of applying a substance, which is capable of inhibiting activity of ADAM present in a skin, to the skin. Anti-wrinkling effects are evaluated with a method wherein enzymatic activity or a gene expression level of ADAM in a skin, a skin tissue, or cells is used as an index.

    Abstract translation: 组合物含有能够以有效预防或补救皱纹的比例抑制存在于皮肤中的ADAM（解聚蛋白和金属蛋白酶）的活性的物质。 通过包括将能够抑制存在于皮肤中的ADAM的活性的物质施用于皮肤的步骤来防止或补救皱纹。 使用其中使用皮肤，皮肤组织或细胞中的ADAM的酶活性或基因表达水平作为指标的方法来评价抗皱效果。

    Plaster enclosing packaging bag
    4.
    发明申请
    Plaster enclosing packaging bag 审中-公开
    石膏包装袋

    公开(公告)号：US20070158227A1

    公开(公告)日：2007-07-12

    申请号：US10587834

    申请日：2005-01-28

    Applicant: Satoshi Amano ,  Sachiko Honma ,  Tetsuro Tateishi ,  Naruhito Higo

    Inventor： Satoshi Amano ,  Sachiko Honma ,  Tetsuro Tateishi ,  Naruhito Higo

    IPC: A61B19/02 ,  B65D73/00 ,  B65D81/26

    CPC classification number: A61K9/7053 ,  A61J1/00 ,  A61K9/7061 ,  A61K31/138 ,  B65D75/26

    Abstract: An object of the present invention is to provide a patch-containing packaging pouch which enables stable storage of a patch containing bisoprolol in a pressure-sensitive adhesive layer. A packaged desiccant 1 of the present invention has a packaging pouch 8 composed of a pair of laminated package members 7a and 7b arranged in mutual opposition, and a patch 10 housed in the space within this packaging pouch 8. Patch 10 is provided with a support 12 and a pressure-sensitive adhesive layer 14 laminated substantially over the entire surface of one side of this support 12. In addition, the pressure-sensitive adhesive layer is composed of a pressure-sensitive adhesive composition containing a pressure-sensitive adhesive and bisoprolol or pharmaceutically acceptable salt thereof. Moreover, a packaged desiccant 20 is housed within packaging pouch 8. The relative humidity within packaging pouch 8 is maintained at 25% or less in a patch-containing packaging pouch 1 having this constitution.

    Abstract translation: 本发明的目的是提供一种能够在压敏粘合剂层中稳定地储存含有比索洛尔的贴剂的贴剂的包装袋。 本发明的包装干燥剂1具有由相互相对设置的一对层叠包装构件7a和7b组成的包装袋8和容纳在该包装袋8内的空间中的贴片10。 贴片10设置有基本上在该支撑体12的一侧的整个表面上层叠的支撑体12和压敏粘合剂层14。 此外，压敏粘合剂层由含有压敏粘合剂和比索洛尔或其药学上可接受的盐的压敏粘合剂组合物组成。 此外，包装干燥剂20容纳在包装袋8内。 在具有这种结构的贴片包装袋1中，包装袋8内的相对湿度保持在25％以下。

    Thermosetting resin composition
    6.
    发明授权
    Thermosetting resin composition 失效
    热固性树脂组合物

    公开(公告)号：US06486266B2

    公开(公告)日：2002-11-26

    申请号：US09924305

    申请日：2001-08-08

    Applicant: Satoshi Amano ,  Hideshi Tomita

    Inventor： Satoshi Amano ,  Hideshi Tomita

    IPC: C08L7900

    CPC classification number: C08L79/00 ,  C08G18/025 ,  C08G59/4042 ,  C08L63/00 ,  C09D163/00 ,  C08L2666/04

    Abstract: A modified carbodiimide resin obtainable by reacting a carbodiimide resin comprising a repeating unit represented by the general formula: —(NCN—R1)- wherein R1 represents a divalent organic group, with an aromatic diamine represented by the general formula: H2N—R2—NH2 wherein R2 represents a divalent organic group having a benzene ring, and a thermosetting resin composition comprising the modified carbodiimide resin and an epoxy resin.

    Abstract translation: 通过使包含由以下通式表示的重复单元的碳二亚胺树脂与其中由通式H2N-R2-NH2表示的芳族二胺反应得到的改性碳化二亚胺树脂： - （NCN-R1） - 其中R 1表示二价有机基团 其中R2表示具有苯环的二价有机基团，和包含改性碳二亚胺树脂和环氧树脂的热固性树脂组合物。

    Resin composition for use in sealant and liquid sealant using the resin composition
    8.
    发明授权
    Resin composition for use in sealant and liquid sealant using the resin composition 失效
    使用树脂组合物的密封剂和液体密封剂中使用的树脂组合物

    公开(公告)号：US06172143B2

    公开(公告)日：2001-01-09

    申请号：US09228389

    申请日：1999-01-12

    Applicant: Satoshi Amano ,  Hideshi Tomita

    Inventor： Satoshi Amano ,  Hideshi Tomita

    IPC: C08K529

    CPC classification number: C09K3/10 ,  C09K2200/0647 ,  C09K2200/0667

    Abstract: A resin composition for use in a liquid sealant, which is composed mainly of an epoxy compound, an epoxy resin curing agent and a polycarbodiimide resin, the proportion of the polycarbodiimide resin being 0.1 to 10 parts by weight relative to 100 parts by weight of the epoxy compound, and which is liquid or fluid at ordinary temperature. The liquid sealant comprises a resin composition which is composed mainly of an epoxy compound and a polycarbodiimide resin, the proportion of the polycarbodiimide resin being 0.1 to 10 parts by weight relative to 100 parts by weight of the epoxy compound, an epoxy resin curing agent, an epoxy resin curing accelerator and an inorganic powder. The sealant is liquid or fluid at ordinary temperature.

    Abstract translation: 用于液体密封剂的树脂组合物，其主要由环氧化合物，环氧树脂固化剂和聚碳二亚胺树脂组成，聚碳二亚胺树脂的比例相对于100重量份的比例为0.1〜10重量份 环氧化合物，在常温下为液体或液体。 液体密封剂包括主要由环氧化合物和聚碳化二亚胺树脂组成的树脂组合物，相对于100重量份的环氧化合物，环氧树脂固化剂，聚碳化二亚胺树脂的比例为0.1〜10重量份， 环氧树脂固化促进剂和无机粉末。 密封剂在常温下为液体或液体。

    Polycarbodiimide copolymer and process for production thereof
    10.
    发明授权
    Polycarbodiimide copolymer and process for production thereof 失效
    聚碳二亚胺共聚物及其制造方法

    公开(公告)号：US6090906A

    公开(公告)日：2000-07-18

    申请号：US268313

    申请日：1999-03-16

    Applicant: Satoshi Amano ,  Norimasa Nakamura

    Inventor： Satoshi Amano ,  Norimasa Nakamura

    IPC: C08G18/09 ,  C08G18/32 ,  C08G18/69 ,  C08G73/00 ,  C08G18/00 ,  C08L49/00

    CPC classification number: C08G73/00 ,  C08G18/095 ,  C08G18/3228 ,  C08G18/69

    Abstract: There are provided a polycarbodiimide copolymer having a main structure represented by the following formula (1): ##STR1## wherein R.sub.1 is an isocyanate residue; R.sub.2 is a polyfunctional liquid rubber residue; X is a urethane bond, an amide bond or a urea bond; p is an integer of 5 to 50; q is an integer of 1 to 5; and r is 0 or 1; and a process for producing the above polycarbodiimide copolymer, which comprises reacting a polyfunctional liquid rubber with an organic diisocyanate in excess of the rubber and then subjecting the diisocyanate components in the reaction system to carbodiimization using a carbodiimidization catalyst. The polycarbodiimide copolymer alleviates the problems of the prior art, has the excellent heat resistance inherently possessed by polycarbodiimide resins, is improved, as compared with conventional polycarbodiimide resins, in thermoformability under heating and pressure when made into a solid such as a powder or granules, and causes no blistering under heating.

    Abstract translation: 提供具有由下式（1）表示的主要结构的聚碳化二亚胺共聚物：其中R1是异氰酸酯残基; R2是多功能液体橡胶残渣; X是氨基甲酸酯键，酰胺键或脲键; p为5〜50的整数。 q为1〜5的整数， r为0或1; 以及制备上述聚碳二亚胺共聚物的方法，其包括使多官能液态橡胶与有机二异氰酸酯反应超过橡胶，然后使用碳二亚胺化催化剂对反应体系中的二异氰酸酯组分进行碳二亚胺化。 聚碳二亚胺共聚物减轻现有技术的问题，与常规聚碳化二亚胺树脂相比，具有优异的聚碳二亚胺树脂所具有的耐热性，在加热和加压下的热成型性方面得到改善，当制成固体如粉末或颗粒时， 并且在加热下不引起起泡。

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