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    Agent for Preventing and Alleviating Wrinkles
    4.
    发明申请
    Agent for Preventing and Alleviating Wrinkles 有权
    防止和减轻皱纹的代理

    公开(公告)号：US20100113450A1

    公开(公告)日：2010-05-06

    申请号：US12530841

    申请日：2008-03-14

    申请人： Makoto TSUNENAGA ,  Mikiko KAMINUMA ,  Masaru SUETSUGU ,  Chika KATAGIRI

    发明人： Makoto TSUNENAGA ,  Mikiko KAMINUMA ,  Masaru SUETSUGU ,  Chika KATAGIRI

    IPC分类号： A61K31/5375 ,  A61K31/4453 ,  A61K31/197 ,  A61K31/196 ,  A61P17/00

    CPC分类号： A61K8/44 ,  A61K8/466 ,  A61K31/197 ,  A61Q19/08

    摘要： The present invention provides an agent for preventing and alleviating wrinkles which has excellent effects of preventing and alleviating wrinkles formed by decreased barrier function of the skin owing to aging or photo aging, that is graphic wrinkles or linear wrinkles. The agent for preventing and alleviating wrinkles consisting of one or more compounds selected from the group consisting of gamma-aminobutyric acid derivatives represented by the following formula (1) or N,N,N-trimethyl gamma-aminobutyric acid represented by the following formula (3) and salts thereof: wherein R1 and R2 independently represent any of a hydrogen atom, an alkyl group having 1 to 3 carbon atoms, a benzyloxycarbonyl group, a cyclohexyl group, a cyclohexanemethyl group, a cyclohexanecarbonyl group, a guanidino group formed with nitrogen atom in the formula (1), an ureido group formed with nitrogen atom in the formula (1), and a group represented by following formula (2). Additionally, R1 and R2 may jointly form a piperidine ring, morpholine ring, or pyrrolidine ring. Both of R1 and R2 are not simultaneously a hydrogen atom.

    摘要翻译： 本发明提供一种防止和减轻皱纹的试剂，其具有优异的防止和减轻由于老化或照片老化导致的皮肤屏障功能形成的皱纹，即图形皱纹或线状皱纹的效果。 用于预防和减轻由一种或多种选自由下式（1）表示的γ-氨基丁酸衍生物或由下式（N）表示的N，N，N-三甲基γ-氨基丁酸组成的组中的化合物组成的皱纹的试剂 3）及其盐：其中R 1和R 2独立地表示氢原子，具有1至3个碳原子的烷基，苄氧基羰基，环己基，环己烷甲基，环己烷羰基，与氮形成的胍基 式（1）中的原子，式（1）中由氮原子形成的脲基和由下式（2）表示的基团。 此外，R 1和R 2可以共同形成哌啶环，吗啉环或吡咯烷环。 R1和R2两者不同时为氢原子。

    Agent for alleviating wrinkles
    7.
    发明授权
    Agent for alleviating wrinkles 有权
    减轻皱纹的代理

    公开(公告)号：US08173705B2

    公开(公告)日：2012-05-08

    申请号：US12530841

    申请日：2008-03-14

    申请人： Makoto Tsunenaga ,  Mikiko Kaminuma ,  Masaru Suetsugu ,  Chika Katagiri

    发明人： Makoto Tsunenaga ,  Mikiko Kaminuma ,  Masaru Suetsugu ,  Chika Katagiri

    IPC分类号： A61K31/195

    CPC分类号： A61K8/44 ,  A61K8/466 ,  A61K31/197 ,  A61Q19/08

    摘要： The present invention provides an agent for preventing and alleviating wrinkles which has excellent effects of preventing and alleviating wrinkles formed by decreased barrier function of the skin owing to aging or photo aging, that is graphic wrinkles or linear wrinkles. The agent for preventing and alleviating wrinkles consisting of one or more compounds selected from the group consisting of gamma-aminobutyric acid derivatives represented by the following formula (1) or N,N,N-trimethyl gamma-aminobutyric acid represented by the following formula (3) and salts thereof: wherein R1 and R2 independently represent any of a hydrogen atom, an alkyl group having 1 to 3 carbon atoms, a benzyloxycarbonyl group, a cyclohexyl group, a cyclohexanemethyl group, a cyclohexanecarbonyl group, a guanidino group formed with nitrogen atom in the formula (1), an ureido group formed with nitrogen atom in the formula (1), and a group represented by following formula (2). Additionally, R1 and R2 may jointly form a piperidine ring, morpholine ring, or pyrrolidine ring. Both of R1 and R2 are not simultaneously a hydrogen atom.

    摘要翻译： 本发明提供一种防止和减轻皱纹的试剂，其具有优异的防止和减轻由于老化或照片老化导致的皮肤屏障功能形成的皱纹，即图形皱纹或线状皱纹的效果。 用于预防和减轻由一种或多种选自由下式（1）表示的γ-氨基丁酸衍生物或由下式（N）表示的N，N，N-三甲基γ-氨基丁酸组成的组中的化合物组成的皱纹的试剂 3）及其盐：其中R 1和R 2独立地表示氢原子，具有1至3个碳原子的烷基，苄氧基羰基，环己基，环己烷甲基，环己烷羰基，与氮形成的胍基 式（1）中的原子，式（1）中由氮原子形成的脲基和由下式（2）表示的基团。 此外，R 1和R 2可以共同形成哌啶环，吗啉环或吡咯烷环。 R1和R2两者不同时为氢原子。

    Method for reducing ultraviolet light induced apoptosis
    10.
    发明申请
    Method for reducing ultraviolet light induced apoptosis 审中-公开
    降低紫外光诱导细胞凋亡的方法

    公开(公告)号：US20070160545A1

    公开(公告)日：2007-07-12

    申请号：US10593955

    申请日：2005-03-18

    申请人： Chika Katagiri ,  Toshihiko Hibino

    发明人： Chika Katagiri ,  Toshihiko Hibino

    IPC分类号： A61K8/49 ,  G01N33/53 ,  C12Q1/68

    CPC分类号： C07K14/47 ,  A61K8/606 ,  A61K48/00 ,  A61Q17/04 ,  G01N33/6893 ,  G01N2510/00 ,  G01N2800/20

    摘要： The present invention provides a method for enhancing resistance to the onset of skin damage caused by irradiation of the skin with ultraviolet light by inhibiting ultraviolet irradiation-induced apoptosis of epidermal cells as a result of increasing expression of SCCA-1 and/or SCCA-2 in epidermal cells. Moreover, the present invention provides a skin testing method for evaluating resistance of the skin to skin damage caused by ultraviolet irradiation by measuring the expression of SCCA-1 and/or SCCA-2 in epidermal cells, and judging UV resistance of the epidermis to be weak in the case expression is decreased as compared with expression in epidermal cells. Moreover, the present invention provides a method for screening drugs which enhance resistance of the skin to skin damage by ultraviolet irradiation by selecting a drug that increases expression of SCCA-1 and/or SCCA-2 as a UV resistance enhancer.

    摘要翻译： 本发明提供一种通过抑制由于SCCA-1和/或SCCA-2的表达增加而导致的表皮细胞的紫外线照射诱导的细胞凋亡而增强由紫外线照射皮肤引起的皮肤损伤发作的抗性的方法 在表皮细胞中。 此外，本发明提供了一种皮肤测试方法，用于通过测量表皮细胞中SCCA-1和/或SCCA-2的表达并评估表皮的抗紫外线性来评估由紫外线照射引起的皮肤对皮肤损伤的抗性 与表皮细胞中的表达相比，病例表达较弱。 此外，本发明提供了通过选择增加作为抗紫外线增强剂的SCCA-1和/或SCCA-2的表达的药物来增强抗紫外线照射对皮肤的皮肤损伤的药物的方法。