公开(公告)号：US5840705A

公开(公告)日：1998-11-24

申请号：US604563

申请日：1996-02-21

申请人： Masayuki Tsukada ,  Hiroyuki Takeda ,  Norio Maeda ,  Yasunori Fukumori ,  Norio Shiomi ,  Shuichi Onodera ,  Takuji Fujisawa

发明人： Masayuki Tsukada ,  Hiroyuki Takeda ,  Norio Maeda ,  Yasunori Fukumori ,  Norio Shiomi ,  Shuichi Onodera ,  Takuji Fujisawa

IPC分类号： A21D2/24 ,  A21D13/08 ,  A23F5/24 ,  A23G1/00 ,  A23G1/30 ,  A23G3/00 ,  A23G3/34 ,  A23G3/36 ,  A23G4/00 ,  A23G4/06 ,  A23K1/16 ,  A23L1/236 ,  A23L1/29 ,  A23L1/30 ,  A61K31/70 ,  A61K45/00 ,  A61P3/08 ,  A61P3/10 ,  A61P43/00 ,  C12N9/26 ,  A01N43/04

CPC分类号： A23G3/36 ,  A21D2/245 ,  A23G4/06 ,  A23K20/153 ,  A23L33/13

摘要： This invention relates an .alpha.-glucosidase inhibitor mildly inhibiting .alpha.-glucosidase locally present in the micro-villus of small intestine, a composition principally comprising sugar and containing the inhibitor, a food, a sweetener and a feed. The inhibitor delays the digestion of starch, starch-derived oligosaccharides and sucrose, so that the inhibitor has an action of suppressing rapid increase in blood glucose level and an action of suppressing insulin secretion at a lower level. Thus, the inhibitor is useful for the prophylaxis of obesity and diabetes mellitus. The .alpha.-glucosidase inhibitor of the present invention is composed of nucleotide, nucleoside, or base as the structural component of nucleic acid and one or two or more digestible sugars selected from sucrose, starch and starch-derived oligosaccharide. The .alpha.-glucosidase inhibitor mildly inhibits the action of .alpha.-glucosidase as a digestive enzyme in small intestine, and has effects of suppressing rapid increase in blood glucose level and suppressing insulin secretion at a lower level. In combination with digestible sugars, the .alpha.-glucosidase inhibitor is applicable as foods, sweeteners and feeds.

摘要翻译： 本发明涉及一种局部存在于小肠微绒毛中的α-葡萄糖苷酶抑制剂，主要包含糖并含有抑制剂的组合物，食品，甜味剂和饲料。 抑制剂延缓了淀粉，淀粉衍生的低聚糖和蔗糖的消化，使得抑制剂具有抑制血糖水平的快速增加和抑制胰岛素分泌较低水平的作用。 因此，该抑制剂可用于预防肥胖症和糖尿病。 本发明的α-葡糖苷酶抑制剂由核酸，核苷或碱作为核酸的结构成分和选自蔗糖，淀粉和淀粉衍生的低聚糖中的一种或两种以上的可消化糖构成。 α-葡萄糖苷酶抑制剂在小肠中轻度抑制α-葡萄糖苷酶作为消化酶的作用，具有抑制血糖水平快速升高并抑制胰岛素分泌水平较低的作用。 结合可消化糖，α-葡糖苷酶抑制剂适用于食品，甜味剂和饲料。

公开(公告)号：US5463038A

公开(公告)日：1995-10-31

申请号：US940788

申请日：1992-09-04

申请人： Tetsuhiro Hidano ,  Hiroyuki Takeda ,  Masayuki Tsukada ,  Kazuo Yamamoto ,  Atsushi Inoue

发明人： Tetsuhiro Hidano ,  Hiroyuki Takeda ,  Masayuki Tsukada ,  Kazuo Yamamoto ,  Atsushi Inoue

IPC分类号： A23L2/39 ,  A23L23/10 ,  A23L27/24 ,  A23L27/30 ,  C07H3/06 ,  C12P19/00 ,  C12R1/645 ,  C07H1/06 ,  C12P19/44

CPC分类号： C07H3/06 ,  A23L2/39 ,  A23L23/10 ,  A23L27/24 ,  A23L27/33 ,  C12P19/00

摘要： The present invention relates to crystals of 1-kestose which is a fructooligosaccharide, and it is an object of the present invention to provide high-purity 1-kestose crystals having no hygroscopicity and a method of producing the crystals. Methanol is added to an aqueous solution containing as a main ingredient 1-kestose with a purity of 80% or more, and the mixture is then dried. Methanol is further added to the mixture to obtain 1-kestose crystals with a purity of 90% or more. An aqueous solution with a purity of 70% or more is concentrated, and 1-kestose microcrystals are added to the concentrate obtained to separate 1-kestose crystals with a purity of 94 to 99.9%.

摘要翻译： 本发明涉及作为低聚果糖的1-kestose的结晶，本发明的目的是提供不具有吸湿性的高纯度1-kestose晶体和晶体的制造方法。 将甲醇加入含有纯度为80％以上的主要成分的1-水溶液的水溶液中，然后将混合物干燥。 进一步向混合物中加入甲醇，得到纯度为90％以上的1-kestose晶体。 将纯度为70％以上的水溶液浓缩，向得到的浓缩物中加入1-kestose微晶，分离出纯度为94〜99.9％的1-kestose晶体。