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    ANTIBODY HAVING ANTI-CANCER ACTIVITY
    2.
    发明申请
    ANTIBODY HAVING ANTI-CANCER ACTIVITY 有权
    具有抗癌活性的抗体

    公开(公告)号：US20120107364A1

    公开(公告)日：2012-05-03

    申请号：US13382468

    申请日：2010-07-07

    申请人： Masunori Kajikawa ,  Masahito Sugiura ,  Kazuyuki Atarashi ,  Emi Shimizu ,  Chiemi Matsumi ,  Yukie Saitoh

    发明人： Masunori Kajikawa ,  Masahito Sugiura ,  Kazuyuki Atarashi ,  Emi Shimizu ,  Chiemi Matsumi ,  Yukie Saitoh

    IPC分类号： A61K39/00 ,  A61P37/04 ,  C12N5/16 ,  A61P35/00 ,  C07K16/30 ,  C12N15/13

    CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K16/3046 ,  C07K2317/73

    摘要： By utilizing an SST-REX method, a cDNA encoding a protein expressed on a cell surface or secreted from the cell was selected from a cDNA library derived from a cancer cell line. Monoclonal antibodies against the protein encoding the selected cDNA were prepared. The in vitro and in vivo anti-cancer activities and binding to various cancer cells lines were examined. As a result, a monoclonal antibody which binds to a PODXL2 protein, and which had excellent anti-cancer activities was found. Further, a region including an epitope of the antibody was successfully identified, and the amino acid sequences of variable regions of a light chain and a heavy chain were successfully determined.

    摘要翻译： 通过使用SST-REX方法，从源自癌细胞系的cDNA文库中选择编码在细胞表面表达或从细胞分泌的蛋白质的cDNA。 制备针对编码所选cDNA的蛋白质的单克隆抗体。 检查体外和体内抗癌活性并结合各种癌细胞系。 结果发现结合PODXL2蛋白的单克隆抗体具有优异的抗癌活性。 此外，成功鉴定了包含抗体的表位的区域，成功地测定了轻链和重链的可变区的氨基酸序列。

    Antibody having anti-cancer activity
    3.
    发明授权
    Antibody having anti-cancer activity 有权
    抗体具有抗癌活性

    公开(公告)号：US08828387B2

    公开(公告)日：2014-09-09

    申请号：US13382468

    申请日：2010-07-07

    申请人： Masunori Kajikawa ,  Masahito Sugiura ,  Kazuyuki Atarashi ,  Emi Shimizu ,  Chiemi Matsumi ,  Yukie Saitoh

    发明人： Masunori Kajikawa ,  Masahito Sugiura ,  Kazuyuki Atarashi ,  Emi Shimizu ,  Chiemi Matsumi ,  Yukie Saitoh

    IPC分类号： A61K39/395 ,  C07K16/30 ,  A61K39/00

    CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K16/3046 ,  C07K2317/73

    摘要： By utilizing an SST-REX method, a cDNA encoding a protein expressed on a cell surface or secreted from the cell was selected from a cDNA library derived from a cancer cell line. Monoclonal antibodies against the protein encoding the selected cDNA were prepared. The in vitro and in vivo anti-cancer activities and binding to various cancer cells lines were examined. As a result, a monoclonal antibody which binds to a PODXL2 protein, and which had excellent anti-cancer activities was found. Further, a region including an epitope of the antibody was successfully identified, and the amino acid sequences of variable regions of a light chain and a heavy chain were successfully determined.

    摘要翻译： 通过使用SST-REX方法，从源自癌细胞系的cDNA文库中选择编码在细胞表面表达或从细胞分泌的蛋白质的cDNA。 制备针对编码所选cDNA的蛋白质的单克隆抗体。 检查体外和体内抗癌活性并结合各种癌细胞系。 结果发现结合PODXL2蛋白的单克隆抗体具有优异的抗癌活性。 此外，成功鉴定了包含抗体的表位的区域，成功地测定了轻链和重链的可变区的氨基酸序列。

    METHODS AND COMPOSITION FOR TESTING, PREVENTING, AND TREATING ASPERGILLUS FUMIGATUS INFECTION
    6.
    发明申请
    METHODS AND COMPOSITION FOR TESTING, PREVENTING, AND TREATING ASPERGILLUS FUMIGATUS INFECTION 审中-公开
    测试，预防和治疗青蒿素感染的方法和组合

    公开(公告)号：US20140242085A1

    公开(公告)日：2014-08-28

    申请号：US14238143

    申请日：2011-08-12

    申请人： Yoshitsugu Miyazaki ,  Satoshi Yamagoe ,  Masunori Kajikawa ,  Masahito Sugiura ,  Reiko Itoh ,  Hirotaka Kumagai

    发明人： Yoshitsugu Miyazaki ,  Satoshi Yamagoe ,  Masunori Kajikawa ,  Masahito Sugiura ,  Reiko Itoh ,  Hirotaka Kumagai

    IPC分类号： C07K16/14 ,  G01N33/569

    CPC分类号： C07K16/14 ,  A61K2039/505 ,  C07K14/38 ,  C07K2317/34 ,  G01N33/56961 ,  G01N2333/38

    摘要： As a result of the analysis by an SST-REX method so as to identify a target molecule for treating and testing an Aspergillus fumigatus infection, a YMAF1 protein has been found out, which is mainly localized in the cell wall of Aspergillus fumigatus. Moreover, it has been found out that YMAF1 protein-deficient Aspergillus fumigatus has reduced spore-forming ability and pathogenicity. Further, it has been found out that the survival rate of experimental mice having aspergillosis (invasive Aspergillus model mice) is improved by preparing and administering an antibody against the YMAF1 protein. Furthermore, it has been found out that Aspergillus fumigatus can be detected with a favorable sensitivity by an ELISA system using the antibody.

    摘要翻译： 作为通过SST-REX法分析以鉴定用于治疗和测试烟曲霉感染的靶分子的结果，已经发现YMAF1蛋白主要位于烟曲霉的细胞壁中。 此外，已经发现YMAF1蛋白缺乏的烟曲霉具有降低的孢子形成能力和致病性。 此外，已经发现，通过制备和施用针对YMAF1蛋白的抗体，改善了具有曲霉菌病（侵入性曲霉属模型小鼠）的实验小鼠的存活率。 此外，已经发现通过使用抗体的ELISA系统可以以良好的灵敏度检测烟曲霉。