公开(公告)号：US20100006092A1

公开(公告)日：2010-01-14

申请号：US12550209

申请日：2009-08-28

申请人： Ron L. Hale ,  Mingzu Lei ,  Peter M. Lloyd ,  Patrik Munzar ,  C.V. Krishnamohan Sharma ,  Dennis W. Solas ,  Matthew D. Stracker

发明人： Ron L. Hale ,  Mingzu Lei ,  Peter M. Lloyd ,  Patrik Munzar ,  C.V. Krishnamohan Sharma ,  Dennis W. Solas ,  Matthew D. Stracker

IPC分类号： A61M15/06 ,  F23Q1/06

CPC分类号： A61M11/041 ,  A61M11/047 ,  A61M15/0031 ,  A61M15/0045

摘要： Aerosol drug delivery devices incorporating percussively activated heat packages are disclosed. The heat packages include a percussive igniter and a fuel capable of undergoing an exothermic oxidation-reduction reaction when ignited by the percussive igniter. The drug delivery devices disclosed can be activated by an actuation mechanism to vaporize a thin solid film comprising a drug disposed on the exterior of a hat package. Metal coordination complexes of volatile drugs, and in particular nicotine, from which the drug can be selectively vaporized when heated are also disclosed. The use of aerosol drug delivery devices comprising thin films of nicotine metal salt complexes for the treatment of nicotine craving and for effecting smoking cessation are also disclosed.

摘要翻译： 公开了包含冲击活化热包装的气溶胶药物递送装置。 热包装包括打击式点火器和能够在被打击式点火器点燃时经历放热氧化还原反应的燃料。 所公开的药物输送装置可以由致动机构激活，以蒸发包括设置在帽子包装的外部上的药物的薄的固体膜。 还公开了挥发性药物的金属配位络合物，特别是加热时药物可以从其中选择性蒸发的尼古丁。 还公开了包括尼古丁金属盐络合物的薄膜用于治疗尼古丁渴望和用于戒烟的气溶胶药物递送装置的使用。

公开(公告)号：US07581540B2

公开(公告)日：2009-09-01

申请号：US10917720

申请日：2004-08-12

申请人： Ron L. Hale ,  Mingzu Lei ,  Peter M. Lloyd ,  Patrik Munzar ,  Krishnamohan Sharma ,  Dennis W. Solas ,  Matthew D. Stracker

发明人： Ron L. Hale ,  Mingzu Lei ,  Peter M. Lloyd ,  Patrik Munzar ,  Krishnamohan Sharma ,  Dennis W. Solas ,  Matthew D. Stracker

IPC分类号： A61M16/00 ,  H05B3/00 ,  A62B7/00 ,  F24J3/00

CPC分类号： A24F47/006 ,  A61M11/041 ,  A61M11/047 ,  A61M11/048 ,  A61M15/0031 ,  A61M15/0045 ,  A61M15/0051 ,  A61M15/06 ,  A61M2202/064 ,  A61M2205/364 ,  A61M2205/8268

摘要： Aerosol drug delivery devices incorporating percussively activated heat packages are disclosed. The heat packages include a percussive igniter and a fuel capable of undergoing an exothermic oxidation-reduction reaction when ignited by the percussive igniter. The drug delivery devices disclosed can be activated by an actuation mechanism to vaporize a thin solid film comprising a drug disposed on the exterior of a hat package. Metal coordination complexes of volatile drugs, and in particular nicotine, from which the drug can be selectively vaporized when heated are also disclosed. The use of aerosol drug delivery devices comprising thin films of nicotine metal salt complexes for the treatment of nicotine craving and for effecting smoking cessation are also disclosed.

摘要翻译： 公开了包含冲击活化热包装的气溶胶药物递送装置。 热包装包括打击式点火器和能够在被打击式点火器点燃时经历放热氧化还原反应的燃料。 所公开的药物输送装置可以由致动机构激活，以蒸发包括设置在帽子包装的外部上的药物的薄的固体膜。 还公开了挥发性药物的金属配位络合物，特别是加热时药物可以从其中选择性蒸发的尼古丁。 还公开了包括尼古丁金属盐络合物的薄膜用于治疗尼古丁渴望和用于戒烟的气溶胶药物递送装置的使用。